Lactate-binding protein DNMT3A in HRMECs promotes angiogenesis by upregulating VEGFA through HIF-1α lactylation

Fevereiro-Martins M, Marques-Neves C, Guimarães H, Bicho M. Retinopathy of prematurity: a review of pathophysiology and signaling pathways. Surv Ophthalmol. 2023;68:175–210.

Article  PubMed  Google Scholar 

Arrigo A, Aragona E, Bandello F. VEGF-targeting drugs for the treatment of retinal neovascularization in diabetic retinopathy. Ann Med. 2022;54:1089–111.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yuan Y, Kong W, Liu XM, Shi GH. A hypoxia-regulated retinal pigment epithelium-specific gene therapy vector reduces choroidal neovascularization in a mouse model. Curr Gene Ther. 2022;22:417–26.

Article  CAS  PubMed  Google Scholar 

Qiu F, Matlock G, Chen Q, Zhou K, Du Y, Wang X, et al. Therapeutic effects of PPARα agonist on ocular neovascularization in models recapitulating neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci. 2017;58:5065–75.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sasore T, Reynolds AL, Kennedy BN. Targeting the PI3K/Akt/mTOR pathway in ocular neovascularization. Adv Exp Med Biol. 2014;801:805–11.

Article  PubMed  Google Scholar 

Wang W, LeBlanc ME, Chen X, Chen P, Ji Y, Brewer M, et al. Pathogenic role and therapeutic potential of pleiotrophin in mouse models of ocular vascular disease. Angiogenesis. 2017;20:479–92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vähätupa M, Järvinen TAH, Uusitalo-Järvinen H. Exploration of oxygen-induced retinopathy model to discover new therapeutic drug targets in retinopathies. Front Pharmacol. 2020;11:873.

Article  PubMed  PubMed Central  Google Scholar 

Babapoor-Farrokhran S, Qin Y, Flores-Bellver M, Niu Y, Bhutto IA, Aparicio-Domingo S, et al. Pathologic vs. protective roles of hypoxia-inducible factor 1 in RPE and photoreceptors in wet vs. dry age-related macular degeneration. Proc Natl Acad Sci U S A. 2023;120:e2302845120.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang J, Muri J, Fitzgerald G, Gorski T, Gianni-Barrera R, Masschelein E, et al. Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization. Cell Metab. 2020;31:1136-1153.e1137.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rabinowitz JD, Enerbäck S. Lactate: the ugly duckling of energy metabolism. Nat Metab. 2020;2:566–71.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee DC, Sohn HA, Park ZY, Oh S, Kang YK, Lee KM, et al. A lactate-induced response to hypoxia. Cell. 2015;161:595–609.

Article  CAS  PubMed  Google Scholar 

Fang X, Zhao P, Gao S, Liu D, Zhang S, Shan M, et al. Lactate induces tumor-associated macrophage polarization independent of mitochondrial pyruvate carrier-mediated metabolism. Int J Biol Macromol. 2023;237:123810.

Article  CAS  PubMed  Google Scholar 

Feng Q, Liu Z, Yu X, Huang T, Chen J, Wang J, et al. Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity. Nat Commun. 2022;13:4981.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gu J, Zhou J, Chen Q, Xu X, Gao J, Li X, et al. Tumor metabolite lactate promotes tumorigenesis by modulating MOESIN lactylation and enhancing TGF-β signaling in regulatory T cells. Cell Rep. 2022;39:110986.

Article  CAS  PubMed  Google Scholar 

Fan W, Wang X, Zeng S, Li N, Wang G, Li R, et al. Global lactylome reveals lactylation-dependent mechanisms underlying T(H)17 differentiation in experimental autoimmune uveitis. Sci Adv. 2023;9:eadh4655.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kumagai S, Koyama S, Itahashi K, Tanegashima T, Lin YT, Togashi Y, et al. Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments. Cancer Cell. 2022;40:201-218.e209.

Article  CAS  PubMed  Google Scholar 

Xu Y, Kusuyama J, Osana S, Matsuhashi S, Li L, Takada H, et al. Lactate promotes neuronal differentiation of SH-SY5Y cells by lactate-responsive gene sets through NDRG3-dependent and -independent manners. J Biol Chem. 2023;299:104802.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Babl N, Decking SM, Voll F, Althammer M, Sala-Hojman A, Ferretti R, et al. MCT4 blockade increases the efficacy of immune checkpoint blockade. J Immunother Cancer. 2023. https://doi.org/10.1136/jitc-2023-007349.

Article  PubMed  PubMed Central  Google Scholar 

Fan M, Yang K, Wang X, Chen L, Gill PS, Ha T, et al. Lactate promotes endothelial-to-mesenchymal transition via Snail1 lactylation after myocardial infarction. Sci Adv. 2023;9:eadc9465.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang X, Fan W, Li N, Ma Y, Yao M, Wang G, et al. Yy1 lactylation in microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2. Genome Biol. 2023;24:87.

Article  PubMed  PubMed Central  Google Scholar 

Huang J, Wang X, Li N, Fan W, Li X, Zhou Q, et al. YY1 lactylation aggravates autoimmune uveitis by enhancing microglial functions via inflammatory genes. Adv Sci. 2024;11:e2308031.

Article  Google Scholar 

Zhang D, Tang Z, Huang H, Zhou G, Cui C, Weng Y, et al. Metabolic regulation of gene expression by histone lactylation. Nature. 2019;574:575–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu J, Chai P, Xie M, Ge S, Ruan J, Fan X, et al. Histone lactylation drives oncogenesis by facilitating m(6)A reader protein YTHDF2 expression in ocular melanoma. Genome Biol. 2021;22:85.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Irizarry-Caro RA, McDaniel MM, Overcast GR, Jain VG, Troutman TD, Pasare C. TLR signaling adapter BCAP regulates inflammatory to reparatory macrophage transition by promoting histone lactylation. Proc Natl Acad Sci U S A. 2020;117:30628–38.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu Y, Brommer B, Tian X, Krishnan A, Meer M, Wang C, et al. Reprogramming to recover youthful epigenetic information and restore vision. Nature. 2020;588:124–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Takata N, Miska JM, Morgan MA, Patel P, Billingham LK, Joshi N, et al. Lactate-dependent transcriptional regulation controls mammalian eye morphogenesis. Nat Commun. 2023;14:4129.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tobita S, Yoshihara T. Intracellular and in vivo oxygen sensing using phosphorescent iridium(III) complexes. Curr Opin Chem Biol. 2016;33:39–45.

Article  CAS  PubMed  Google Scholar 

He Q, Ma Y, Liu J, Zhang D, Ren J, Zhao R, et al. Biological functions and regulatory mechanisms of Hypoxia-inducible factor-1α in ischemic stroke. Front Immunol. 2021;12:801985.

Article  CAS  PubMed  PubMed Central 

Comments (0)

No login
gif