Rudin, C. M., Brambilla, E., Faivre-Finn, C., & Sage, J. (2021). Small-cell lung cancer. Nature Reviews Disease Primers, 7(1), 3. https://doi.org/10.1038/s41572-020-00235-0

Article  PubMed  PubMed Central  Google Scholar 

Megyesfalvi, Z., Gay, C. M., Popper, H., Pirker, R., Ostoros, G., Heeke, S., Lang, C., Hoetzenecker, K., Schwendenwein, A., Boettiger, K., Bunn, P. A., Jr., Renyi‐Vamos, F., Schelch, K., Prosch, H., Byers, L. A., Hirsch, F. R., & Dome, B. (2023). Clinical insights into small cell lung cancer: Tumor heterogeneity, diagnosis, therapy, and future directions. CA: A Cancer Journal for Clinicians. https://doi.org/10.3322/caac.21785

Article  PubMed  Google Scholar 

Gazdar, A. F., Bunn, P. A., & Minna, J. D. (2017). Small-cell lung cancer: What we know, what we need to know and the path forward. Nature Reviews Cancer, 17(12), 725–737. https://doi.org/10.1038/nrc.2017.87

Article  PubMed  CAS  Google Scholar 

Meuwissen, R., Linn, S. C., Linnoila, R. I., Zevenhoven, J., Mooi, W. J., & Berns, A. (2003). Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model. Cancer Cell, 4(3), 181–189. https://doi.org/10.1016/S1535-6108(03)00220-4

Article  PubMed  CAS  Google Scholar 

Semenova, E. A., Nagel, R., & Berns, A. (2015). Origins, genetic landscape, and emerging therapies of small cell lung cancer. Genes & Development, 29(14), 1447–1462. https://doi.org/10.1101/gad.263145.115

Article  CAS  Google Scholar 

George, J., Lim, J. S., Jang, S. J., Cun, Y., Ozretić, L., Kong, G., Leenders, F., Lu, X., Fernández-Cuesta, L., Bosco, G., Müller, C., Dahmen, I., Jahchan, N. S., Park, K.-S., Yang, D., Karnezis, A. N., Vaka, D., Torres, A., Wang, M. S., … Thomas, R. K. (2015). Comprehensive genomic profiles of small cell lung cancer. Nature, 524(7563), 47–53. https://doi.org/10.1038/nature14664

Article  PubMed  PubMed Central  CAS  Google Scholar 

Helin, K., Holm, K., Niebuhr, A., Eiberg, H., Tommerup, N., Hougaard, S., Poulsen, H. S., Spang-Thomsen, M., & Nørgaard, P. (1997). Loss of the retinoblastoma protein-related p130 protein in small cell lung carcinoma. Proceedings of the National Academy of Sciences of the United States of America, 94(13), 6933–6938. https://doi.org/10.1073/pnas.94.13.6933

Article  PubMed  PubMed Central  CAS  Google Scholar 

Schaffer, B. E., Park, K.-S., Yiu, G., Conklin, J. F., Lin, C., Burkhart, D. L., Karnezis, A. N., Sweet-Cordero, E. A., & Sage, J. (2010). Loss of p130 accelerates tumor development in a mouse model for human small-cell lung carcinoma. Cancer Research, 70(10), 3877–3883. https://doi.org/10.1158/0008-5472.CAN-09-4228

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gazdar, A. F., Savage, T. K., Johnson, J. E., Berns, A., Sage, J., Linnoila, R. I., MacPherson, D., McFadden, D. G., Farago, A., Jacks, T., Travis, W. D., & Brambilla, E. (2015). The comparative pathology of genetically engineered mouse models for neuroendocrine carcinomas of the lung. Journal of Thoracic Oncology, 10(4), 553–564. https://doi.org/10.1097/JTO.0000000000000459

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cui, M., Augert, A., Rongione, M., Conkrite, K., Parazzoli, S., Nikitin, A. Y., Ingolia, N., & MacPherson, D. (2014). PTEN is a potent suppressor of small cell lung cancer. Molecular Cancer Research, 12(5), 654–659. https://doi.org/10.1158/1541-7786.MCR-13-0554

Article  PubMed  CAS  Google Scholar 

McFadden, D. G., Papagiannakopoulos, T., Taylor-Weiner, A., Stewart, C., Carter, S. L., Cibulskis, K., McFadden, D., Carter, S., Bhutkar, A., McKenna, A., Dooley, A., Vernon, A., Sougnez, C., Malstrom, S., Heimann, M., Park, J., Chen, F., Farago, A., Dayton, T., … Jacks, T. (2014). Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing. Cell, 156(6), 1298–1311. https://doi.org/10.1016/j.cell.2014.02.031

Article  PubMed  PubMed Central  CAS  Google Scholar 

Mollaoglu, G., Guthrie, M. R., Böhm, S., Brägelmann, J., Can, I., Ballieu, P. M., Marx, A., George, J., Heinen, C., Chalishazar, M. D., Cheng, H., Ireland, A. S., Denning, K. E., Mukhopadhyay, A., Vahrenkamp, J. M., Berrett, K. C., Mosbruger, T. L., Wang, J., Kohan, J. L., … Oliver, T. G. (2017). MYC drives progression of small cell lung cancer to a variant neuroendocrine subtype with vulnerability to aurora kinase inhibition. Cancer Cell, 31(2), 270–285. https://doi.org/10.1016/j.ccell.2016.12.005

Article  PubMed  PubMed Central  CAS  Google Scholar 

Denny, S. K., Yang, D., Chuang, C.-H., Brady, J. J., Lim, J. S., Grüner, B. M., Chiou, S.-H., Schep, A. N., Baral, J., Hamard, C., Antoine, M., Wislez, M., Kong, C. S., Connolly, A. J., Park, K.-S., Sage, J., Greenleaf, W. J., & Winslow, M. M. (2016). Nfib promotes metastasis through a widespread increase in chromatin accessibility. Cell, 166(2), 328–342. https://doi.org/10.1016/j.cell.2016.05.052

Article  PubMed  PubMed Central  CAS  Google Scholar 

Semenova, E. A., Kwon, M., Monkhorst, K., Song, J.-Y., Bhaskaran, R., Krijgsman, O., Semenova, E., Kwon, M.-C., Kuilman, T., Peters, D., Buikhuisen, W., Smit, E., Pritchard, C., Cozijnsen, M., van der Vliet, J., Zevenhoven, J., Lambooij, J.-P., Proost, N., van Montfort, E., … Berns, A. (2016). Transcription factor NFIB is a driver of small cell lung cancer progression in mice and marks metastatic disease in patients. Cell Reports, 16(3), 631–643. https://doi.org/10.1016/j.celrep.2016.06.020

Article  PubMed  CAS  Google Scholar 

Rudin, C. M., Poirier, J. T., Byers, L. A., Dive, C., Dowlati, A., George, J., Heymach, J. V., Johnson, J. E., Lehman, J. M., MacPherson, D., Massion, P. P., Minna, J. D., Oliver, T. G., Quaranta, V., Sage, J., Thomas, R. K., Vakoc, C. R., & Gazdar, A. F. (2019). Molecular subtypes of small cell lung cancer: A synthesis of human and mouse model data. Nature Reviews Cancer, 19(5), 289–297. https://doi.org/10.1038/s41568-019-0133-9

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ireland, A. S., Micinski, A. M., Kastner, D. W., Guo, B., Wait, S. J., Spainhower, K. B., Conley, C. C., Chen, O. S., Guthrie, M. R., Soltero, D., Qiao, Yi. ., Huang, X., Tarapcsák, S., Devarakonda, S., Chalishazar, M. D., Gertz, J., Moser, J. C., Marth, G., Puri, S., & Oliver, T. G. (2020). MYC drives temporal evolution of small cell lung cancer subtypes by reprogramming neuroendocrine fate. Cancer Cell. https://doi.org/10.1016/j.ccell.2020.05.001

Article  PubMed  PubMed Central  Google Scholar 

Yang, D., Denny, S. K., Greenside, P. G., Chaikovsky, A. C., Brady, J. J., Ouadah, Y., & Winslow, M. M. (2018). Intertumoral heterogeneity in SCLC is influenced by the cell type of origin. Cancer Discovery, 8(10), 1316–1331. https://doi.org/10.1158/2159-8290.CD-17-0987

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chen, J., Guanizo, A., Luong, Q., Jayasekara, W. S. N., Jayasinghe, D., Inampudi, C., Szczepny, A., Garama, D. J., Russell, P. A., Ganju, V., Cain, J. E., Watkins, D. N., & Gough, D. J. (2022). Lineage-restricted neoplasia driven by myc defaults to small cell lung cancer when combined with loss of p53 and rb in the airway epithelium. Oncogene, 41(1), 138–145. https://doi.org/10.1038/s41388-021-02070-3

Article  PubMed  CAS  Google Scholar 

Olsen, R. R., Ireland, A. S., Kastner, D. W., Groves, S. M., Spainhower, K. B., Pozo, K., Kelenis, D. P., Whitney, C. P., Guthrie, M. R., Wait, S. J., Soltero, D., Witt, B. L., Quaranta, V., Johnson, J. E., & Oliver, T. G. (2021). ASCL1 represses a SOX9+ neural crest stem-like state in small cell lung cancer. Genes & Development, 35(11–12), 847–869. https://doi.org/10.1101/gad.348295.121

Article  CAS  Google Scholar 

Gardner, E. E., Earlie, E. M., Li, K., Thomas, J., Hubisz, M. J., Stein, B. D., & Varmus, H. (2024). Lineage-specific intolerance to oncogenic drivers restricts histological transformation. Science, 383(6683), Article eadj1415. https://doi.org/10.1126/science.adj1415

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sutherland, K. D., Proost, N., Brouns, I., Adriaensen, D., Song, J.-Y., & Berns, A. (2011). Cell of origin of small cell lung cancer: Inactivation of Trp53 and Rb1 in distinct cell types of adult mouse lung. Cancer Cell, 19(6), 754–764. https://doi.org/10.1016/j.ccr.2011.04.019

Article  PubMed  CAS  Google Scholar 

Ferone, G., Song, J.-Y., Krijgsman, O., Vliet, J., Cozijnsen, M., Semenova, E. A., van der Vliet, J., Adams, D. J., Peeper, D., & Berns, A. (2020). FGFR1 oncogenic activation reveals an alternative cell of origin of SCLC in Rb1/p53 mice. Cell Reports, 30(11), 3837-3850.e3. https://doi.org/10.1016/j.celrep.2020.02.052

Article  PubMed  CAS  Google Scholar 

Oser, M. G., MacPherson, D., Oliver, T. G., Sage, J., & Park, K.-S. (2024). Genetically-engineered mouse models of small cell lung cancer: The next generation. Oncogene, 43(7), 457–469. https://doi.org/10.1038/s41388-023-02929-7

Article