Konstantinopoulos, P. A. & Matulonis, U. A. Clinical and translational advances in ovarian cancer therapy. Nat. Cancer 4, 1239–1257 (2023).

Henderson, J. T., Webber, E. M. & Sawaya, G. F. Screening for ovarian cancer: updated evidence report and systematic review for the us preventive services task force. JAMA 319, 595–606 (2018).

Article  PubMed  Google Scholar 

Rickard, B. P. et al. Malignant ascites in ovarian cancer: cellular, acellular, and biophysical determinants of molecular characteristics and therapy response. Cancers 13, 4318 (2021).

Luyckx, M., Squifflet, J. L., Bruger, A. M. & Baurain, J. F. in Ovarian Cancer (ed. Lele, S.) Ch. 6 (Exon Publications, 2022).

Slattery, K. et al. Uptake of lipids from ascites drives NK cell metabolic dysfunction in ovarian cancer. Sci. Immunol. 10, eadr4795 (2025).

Article  CAS  PubMed  Google Scholar 

Jagannath, A. et al. The multiple roles of salt-inducible kinases in regulating physiology. Physiol. Rev. 103, 2231–2269 (2023).

Article  CAS  PubMed  Google Scholar 

Shi, X. et al. SIK2 promotes ovarian cancer cell motility and metastasis by phosphorylating MYLK. Mol. Oncol. 16, 2558–2574 (2022).

Article  CAS  PubMed  Google Scholar 

Tarumoto, Y. et al. Salt-inducible kinase inhibition suppresses acute myeloid leukemia progression in vivo. Blood 135, 56–70 (2020).

Article  CAS  PubMed  Google Scholar 

Song, M. et al. IRE1α–XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity. Nature 562, 423–428 (2018).

Article  CAS  PubMed  Google Scholar 

Fraser, C. C. et al. Ovarian cancer ascites inhibits transcriptional activation of NK cells partly through CA125. J. Immunol. 208, 2227–2238 (2022).

Cubillos-Ruiz, J. R. et al. ER stress sensor XBP1 controls anti-tumor immunity by disrupting dendritic cell homeostasis. Cell 161, 1527–1538 (2015).

Article  CAS  PubMed  Google Scholar 

Conejo-Garcia, J. R. et al. Tumor-infiltrating dendritic cell precursors recruited by a β-defensin contribute to vasculogenesis under the influence of Vegf-A. Nat. Med. 10, 950–958 (2004).

Article  CAS  PubMed  Google Scholar 

Chae, C. S. et al. Tumor-derived lysophosphatidic acid blunts protective type i interferon responses in ovarian cancer. Cancer Discov. 12, 1904–1921 (2022).

Article  CAS  PubMed  Google Scholar 

Ding, L. et al. PARP inhibition elicits STING-dependent antitumor immunity in Brca1-deficient ovarian cancer. Cell Rep. 25, 2972–2980 (2018).

Article  CAS  PubMed  Google Scholar 

Zhou, J. et al. A novel compound ARN-3236 inhibits salt-inducible kinase 2 and sensitizes ovarian cancer cell lines and xenografts to paclitaxel. Clin. Cancer Res. 23, 1945–1954 (2017).

Article  CAS  PubMed  Google Scholar 

Lombardi, M. S., Gillieron, C., Dietrich, D. & Gabay, C. SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype. J. Leukoc. Biol. 99, 711–721 (2016).

Article  CAS  PubMed  Google Scholar 

Sundberg, T. B. et al. Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells. Proc. Natl Acad. Sci. USA 111, 12468–12473 (2014).

Article  CAS  PubMed  Google Scholar 

Park, S. A. et al. IA-0130, a novel 3-(1,3-diarylallylidene)oxindole derivative, alleviates ovarian cancer via inhibiting IL-6/gp130/STAT3 signalling. Br. J. Pharmacol. 182, 5670–5689 (2025).

Article  CAS  PubMed  Google Scholar 

Amer, H. et al. Interleukin-6 is a crucial factor in shaping the inflammatory tumor microenvironment in ovarian cancer and determining its hot or cold nature with diagnostic and prognostic utilities. Cancers 17, 1691 (2025).

Devenport, J. M. et al. APOBEC3A drives ovarian cancer metastasis by altering epithelial–mesenchymal transition. JCI Insight 10, e186409 (2025).

Yoon, S. H. et al. A parathyroid hormone/salt-inducible kinase signaling axis controls renal vitamin D activation and organismal calcium homeostasis. J. Clin. Invest. 133, e163627 (2023).

Nefla, M., Darling, N. J., van Gijsel Bonnello, M., Cohen, P. & Arthur, J. S. C. Salt inducible kinases 2 and 3 are required for thymic T cell development. Sci. Rep. 11, 21550 (2021).

Article  CAS  PubMed  Google Scholar 

Salerno, F. et al. Translational repression of pre-formed cytokine-encoding mRNA prevents chronic activation of memory T cells. Nat. Immunol. 19, 828–837 (2018).

Article  CAS  PubMed  Google Scholar 

Moore, M. J. et al. ZFP36 RNA-binding proteins restrain T cell activation and anti-viral immunity. eLife 7, e33057 (2018).

Muri, J., Thut, H. & Kopf, M. The thioredoxin-1 inhibitor Txnip restrains effector T-cell and germinal center B-cell expansion. Eur. J. Immunol. 51, 115–124 (2021).

Article  CAS  PubMed  Google Scholar 

Malone, C. F. et al. mTOR and HDAC inhibitors converge on the TXNIP/Thioredoxin pathway to cause catastrophic oxidative stress and regression of RAS-driven tumors. Cancer Discov. 7, 1450–1463 (2017).

Article  CAS  PubMed  Google Scholar 

Alhawiti, N. M., Al Mahri, S., Aziz, M. A., Malik, S. S. & Mohammad, S. TXNIP in metabolic regulation: physiological role and therapeutic outlook. Curr. Drug Targets 18, 1095–1103 (2017).

Article  CAS  PubMed  Google Scholar 

Lerner, A. G. et al. IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metab. 16, 250–264 (2012).

Article  CAS  PubMed  Google Scholar 

Cao, J. et al. Effects of altered glycolysis levels on CD8+ T cell activation and function. Cell Death Dis. 14, 407 (2023).

Article  CAS  PubMed  Google Scholar 

Sharma, P. et al. Chediak–Higashi syndrome: a review of the past, present, and future. Drug Discov. Today Dis. Models 31, 31–36 (2020).

Article  PubMed  Google Scholar 

Barbosa, M. D. et al. Identification of the homologous beige and Chediak–Higashi syndrome genes. Nature 382, 262–265 (1996).

Article  CAS  PubMed  Google Scholar 

Mollaoglu, G. et al. Ovarian cancer-derived IL-4 promotes immunotherapy resistance. Cell 187, 7492–7510 (2024).

Article  CAS  PubMed  Google Scholar 

Li, J. et al. Serotonin-licensed macrophages potentiate chemoresistance via inositol metabolic crosstalk in ovarian cancer. Cell Metab. 38, 331–349 (2025).

Sundberg, T. B. et al. Development of chemical probes for investigation of salt-inducible kinase function in vivo. ACS Chem. Biol. 11, 2105–2111 (2016).

Article  CAS  PubMed  Google Scholar 

Lu, Z. et al. SIK2 inhibition enhances PARP inhibitor activity synergistically in ovarian and triple-negative breast cancers. J. Clin. Invest. 132, e146471 (2022).

Fan, D. et al. A novel salt inducible kinase 2 inhibitor, ARN-3261, sensitizes ovarian cancer cell lines and xenografts to carboplatin. Cancers 13, 446 (2021).

Hua, Y. et al. Salt-inducible kinase 2-triggered release of its inhibitor from hydrogel to suppress ovarian cancer metastasis. Adv. Sci. 9, e2202260 (2022).

Article  Google Scholar 

Tang, C. C. et al. Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption. eLife 10, e67772 (2021).

Rachmin, I. et al. A novel approach to target skin photodamage: topical application of salt inducible kinase inhibitors. Int. J. Cosmet. Sci. 48, 1–15 (2025).

Medina, C. B. et al. Pannexin 1 channels facilitate communication between T cells to restrict the severity of airway inflammation. Immunity 54, 1715–1727 (2021).

Article  CAS  PubMed  Google Scholar 

Helms, R. S. et al. SIKs regulate HDAC7 stabilization and cytokine recall in late-stage T cell effector differentiation. J. Immunol. 211, 1767–1782 (2023).

Poffenberger, M. C. et al. LKB1 deficiency in T cells promotes the development of gastrointestinal polyposis. Science 361, 406–411 (2018).

Article  CAS  PubMed  Google Scholar 

Xu, N. et al. Targeting MondoA–TXNIP restores antitumour immunity in lactic-acid-induced immunosuppressive microenvironment. Nat. Metab. 7, 1889–1904 (2025).

Article  CAS  PubMed  Google Scholar 

Sullivan, W. J. et al. Extracellular matrix remodeling regulates glucose metabolism through TXNIP destabilization. Cell 175, 117–132 (2018).

Article  CAS  PubMed