Regenerative endodontic procedures (REPs) were introduced approximately 20 years ago as a promising therapeutic alternative for treating immature necrotic teeth, demonstrating satisfactory long-term success rates [1–3]. These procedures have since proven effective in reliably assessing and managing the signs and symptoms of pulp necrosis and apical periodontitis, even in cases involving traumatized immature teeth with apical involvement [4].

The primary objective of REPs is to alleviate symptoms of periapical pathology and promote periapical healing [[1], [2], [3]]. Secondary and tertiary goals include preserving root canal wall thickness, encouraging root development, and assessing pulp responses to vitality tests, which may indicate the presence of organized vital pulp tissue [5]. In pursuit of these objectives, the use of lasers in REPs has shown promising potential [6].

The treatment of immature necrotic teeth presents a challenge for clinicians because of incomplete root formation and an open apex [7]. REPs are based on tissue engineering principles, utilizing the triad of stem cells, scaffolds, and bioactive molecules [8,9]. Although a standardized protocol is lacking, the therapy typically begins with root canal disinfection, followed by the induction of a blood clot within the canal [10]. This clot serves as a scaffold for the migration, adhesion, and proliferation of SCAPs, while also acting as a reservoir of growth factors [7].

The use of lasers for endodontic applications has been extensively investigated, showcasing advantages over conventional methods [[11], [12], [13]]. Depending on the type of laser used, contact with various tissues can induce thermal, photochemical, and non-linear effects, making it applicable for therapy, prevention, and aesthetic purposes, with excellent tissue tolerance [14]. Commonly utilized lasers for endodontic purposes include the erbium-doped yttrium aluminum garnet laser (Er:YAG), erbium chromium-doped yttrium scandium gallium garnet laser (Er,Cr:YSGG), neodymium-doped yttrium aluminum garnet laser (Nd:YAG), neodymium-doped yttrium perovskite laser (Nd:YAP), carbon dioxide (CO2) lasers, and diode lasers [15].

Therefore, when assessing the potential of lasers, their application in REPs emerges as a logical and well-supported choice [16,17]. Photobiomodulation (PBM), for example, stimulates cell growth, enhances cellular metabolism, improves tissue regeneration, promotes tissue response and accelerates dentin regeneration following pulp exposure [18,19]. Photodynamic therapy (PDT) has also demonstrated positive outcomes as an adjunct to intracanal cleaning and antimicrobial removal [20] . Additionally, lasers can be used in combination with irrigation solutions, yielding favorable results such as root closure and increased root thickness in immature necrotic teeth [21]

Laser-assisted therapies have been proposed as adjunctive treatments in REPs, including photobiomodulation [22] and photodynamic therapies [23]. These applications involve root canal disinfection, dentinal tubule occlusion, and enhancement of apical cell release, viability, migration, and angiogenesis [24]. While previous studies have highlighted the role of photobiomodulation in REPs [22], the potential of laser-assisted therapies expands to new and broader dimensions, still little explored [22,23]. Therefore, this scoping review addresses the following research question: What are the main advances in using lasers in REPs, and what advantages do they offer over conventional methods?