Sun H, Saeedi P, Karuranga S, et al. IDF Diabetes Atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract. 2022;183:109119. https://doi.org/10.1016/j.diabres.2021.109119.

Article  PubMed  Google Scholar 

Ducat L, Philipson LH, Anderson BJ. The mental health comorbidities of diabetes. JAMA. 2014;312(7):691–2. https://doi.org/10.1001/jama.2014.8040.

Article  CAS  PubMed  PubMed Central  Google Scholar 

van der Feltz-Cornelis C, Allen SF, Holt RIG, et al. Treatment for comorbid depressive disorder or subthreshold depression in diabetes mellitus: systematic review and meta-analysis. Brain Behav. 2021;11(2):e01981. https://doi.org/10.1002/brb3.1981.

Article  CAS  PubMed  Google Scholar 

Moulton CD, Pickup JC, Ismail K. The link between depression and diabetes: the search for shared mechanisms. Lancet Diabetes Endocrinol. 2015;3(6):461–71. https://doi.org/10.1016/s2213-8587(15)00134-5.

Article  PubMed  Google Scholar 

Hossain MM, Rahman M, Trisha NF, et al. Prevalence of anxiety and depression in South Asia during COVID-19: a systematic review and meta-analysis. Heliyon. 2021;7(4):e06677. https://doi.org/10.1016/j.heliyon.2021.e06677.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li W, Zhao Z, Chen D, et al. Prevalence and associated factors of depression and anxiety symptoms among college students: a systematic review and meta-analysis. J Child Psychol Psychiatry. 2022;63(11):1222–30. https://doi.org/10.1111/jcpp.13606.

Article  PubMed  Google Scholar 

Smith KJ, Béland M, Clyde M, et al. Association of diabetes with anxiety: a systematic review and meta-analysis. J Psychosom Res. 2013;74(2):89–99. https://doi.org/10.1016/j.jpsychores.2012.11.013.

Article  PubMed  Google Scholar 

Mersha AG, Tollosa DN, Bagade T, et al. A bidirectional relationship between diabetes mellitus and anxiety: a systematic review and meta-analysis. J Psychosom Res. 2022;162:110991. https://doi.org/10.1016/j.jpsychores.2022.110991.

Article  PubMed  Google Scholar 

Lloyd CE, Dyer PH, Barnett AH. Prevalence of symptoms of depression and anxiety in a diabetes clinic population. Diabet Med. 2000;17(3):198–202. https://doi.org/10.1046/j.1464-5491.2000.00260.x.

Article  CAS  PubMed  Google Scholar 

Buchberger B, Huppertz H, Krabbe L, et al. Symptoms of depression and anxiety in youth with type 1 diabetes: a systematic review and meta-analysis. Psychoneuroendocrinology. 2016;70:70–84. https://doi.org/10.1016/j.psyneuen.2016.04.019.

Article  PubMed  Google Scholar 

Bystritsky A, Danial J, Kronemyer D. Interactions between diabetes and anxiety and depression: implications for treatment. Endocrinol Metab Clin North Am. 2014;43(1):269–83. https://doi.org/10.1016/j.ecl.2013.10.001.

Article  PubMed  Google Scholar 

Farzi A, Hassan AM, Zenz G, et al. Diabesity and mood disorders: multiple links through the microbiota-gut-brain axis. Mol Aspects Med. 2019;66:80–93. https://doi.org/10.1016/j.mam.2018.11.003.

Article  CAS  PubMed  Google Scholar 

Habib S, Sangaraju SL, Yepez D, et al. The nexus between diabetes and depression: a narrative review. Cureus. 2022;14(6):e25611. https://doi.org/10.7759/cureus.25611.

Article  PubMed  PubMed Central  Google Scholar 

Bickett A, Tapp H. Anxiety and diabetes: innovative approaches to management in primary care. Exp Biol Med (Maywood). 2016;241(15):1724–31. https://doi.org/10.1177/1535370216657613.

Article  CAS  PubMed  Google Scholar 

Derijks HJ, Meyboom RH, Heerdink ER, et al. The association between antidepressant use and disturbances in glucose homeostasis: evidence from spontaneous reports. Eur J Clin Pharmacol. 2008;64(5):531–8. https://doi.org/10.1007/s00228-007-0441-y.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Larsen PJ, Holst JJ. Glucagon-related peptide 1 (GLP-1): hormone and neurotransmitter. Regul Pept. 2005;128(2):97–107. https://doi.org/10.1016/j.regpep.2004.08.026.

Article  CAS  PubMed  Google Scholar 

Kinzig KP, D’Alessio DA, Herman JP, et al. CNS glucagon-like peptide-1 receptors mediate endocrine and anxiety responses to interoceptive and psychogenic stressors. J Neurosci. 2003;23(15):6163–70. https://doi.org/10.1523/jneurosci.23-15-06163.2003.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guerrero-Hreins E, Goldstone AP, Brown RM, et al. The therapeutic potential of GLP-1 analogues for stress-related eating and role of GLP-1 in stress, emotion and mood: a review. Prog Neuropsychopharmacol Biol Psychiatry. 2021;110:110303. https://doi.org/10.1016/j.pnpbp.2021.110303.

Article  CAS  PubMed  Google Scholar 

Ghosal S, Myers B, Herman JP. Role of central glucagon-like peptide-1 in stress regulation. Physiol Behav. 2013;122:201–7. https://doi.org/10.1016/j.physbeh.2013.04.003.

Article  CAS  PubMed  Google Scholar 

Chen X, Zhao P, Wang W, et al. The antidepressant effects of GLP-1 receptor agonists: a systematic review and meta-analysis. Am J Geriatr Psychiatry. 2023. https://doi.org/10.1016/j.jagp.2023.08.010.

Article  PubMed  PubMed Central  Google Scholar 

Pozzi M, Mazhar F, Peeters G, et al. A systematic review of the antidepressant effects of glucagon-like peptide 1 (GLP-1) functional agonists. J Affect Disord. 2019; 257. https://doi.org/10.1016/j.jad.2019.05.044.

Sterne JAC, Savović J, Page MJ, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898. https://doi.org/10.1136/bmj.l4898.

Article  PubMed  Google Scholar 

Wells GA, Shea B, O’Connel D, et al. 2012. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp. Accessed 15 Oct 2023.

Fahmy O, Fahmy UA, Alhakamy NA, et al. Single-port versus multiple-port robot-assisted radical prostatectomy: a systematic review and meta-analysis. J Clin Med. 2021;10(24). https://doi.org/10.3390/jcm10245723.

Schuch FB, Vancampfort D, Firth J, et al. Physical activity and incident depression: a meta-analysis of prospective cohort studies. Am J Psychiatry. 2018;175(7):631–48. https://doi.org/10.1176/appi.ajp.2018.17111194.

Article  PubMed  Google Scholar 

Higgins J, Thomas J, Chandler J, et al. Cochrane Handbook for Systematic Reviews of Interventions. 2nd ed. Chichester (UK): John Wiley & Sons; 2019.

Book  Google Scholar 

Ishii H, Nakajima H, Kamei N, et al. Quality-of-life comparison of dapagliflozin versus dipeptidyl peptidase 4 inhibitors in patients with type 2 diabetes mellitus: a randomized controlled trial (J-BOND study). Diabetes Ther. 2020;11(12):2959–77. https://doi.org/10.1007/s13300-020-00941-8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bode BW, Testa MA, Magwire M, et al. Patient-reported outcomes following treatment with the human GLP-1 analogue liraglutide or glimepiride in monotherapy: results from a randomized controlled trial in patients with type 2 diabetes. Diabetes Obes Metab. 2010;12(7):604–12. https://doi.org/10.1111/j.1463-1326.2010.01196.x.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Astra Z 2015. Safety and efficacy of exenatide in patients with type 2 diabetes using a thiazolidinedione or a thiazolidinedione and metformin https://www.clinicaltrials.gov/study/NCT00603239?cond=diabetes&term=anxiety&intr=glp-1&aggFilters=results:with&rank=6. Accessed 13 Mar 2024.

Nordisk N 2021. A double-blinded trial comparing the efficacy and safety of insulin degludec/​liraglutide and insulin degludec both in combination with metformin in japanese subjects with type 2 diabetes mellitus inadequately controlled with basal or pre-mix/​combination insulin therapy and oral anti-diabetic drugs (DUAL™ II Japan) https://www.clinicaltrials.gov/study/NCT02911948?cond=diabetes&term=anxiety&intr=glp-1&aggFilters=results:with&rank=3. Accessed 13 Mar 2024.

--- 2021. Dose-response, Safety and efficacy of oral semaglutide versus placebo and versus liraglutide, all as monotherapy in Japanese subjects with type 2 diabetes (PIONEER 9) https://www.clinicaltrials.gov/study/NCT03018028?cond=diabetes&term=anxiety&intr=glp-1&aggFilters=results:with&rank=8. Accessed 13 Mar 2024.

Goto H, Mita T, Fujitani Y, et al. Effects of linagliptin versus voglibose on treatment-related quality of life in patients with type 2 diabetes: sub-analysis of the L-STEP study. Endocr J. 2018;65(6):657–68. https://doi.org/10.1507/endocrj.EJ18-0088.

Article  CAS  PubMed  Google Scholar 

Mita T, Hiyoshi T, Yoshii H, et al. The effect of linagliptin versus metformin treatment-related quality of life in patients with type 2 diabetes mellitus. Diabetes Ther. 2019;10(1):119n treatment-related quality of life in patients.