Available online 26 July 2025, 112040

Schizophrenia patients show reduced hippocampal subfield volumes and memory deficits.

Left CA1 volume is positively associated with recall performance in schizophrenia.

Thematic recall correlates with left CA1, CA3, and CA4/DG volumes in schizophrenia.

Findings highlight hippocampal subfield involvement in memory deficits in schizophrenia.

Results may inform targeted interventions for memory impairment in schizophrenia.

Schizophrenia is a debilitating disorder commonly associated with significant cognitive impairment, particularly in memory. Reduced gray matter volume in various brain regions, including hippocampus and its subfields, is also well-documented in individuals with schizophrenia (SZH). However, few studies have investigated how memory deficits relate to hippocampal subfield volume loss.

In this study, we examined hippocampal subfield volumes and their associations with immediate and delayed memory performance (using the WMS-III battery), comparing 57 individuals with SZH to 32 well-matched controls.

Compared to controls, SZH exhibited lower memory performance, and lower hippocampal volumes, particularly in the left hippocampus and parasubiculum, CA1 subfields specifically. Both Immediate and Delayed Free Recall memory performance was seen to be positively correlated with left CA1 volume in SZH only, and not in controls. Positive associations were also observed between Thematic Recall scores and volumes in the left CA1, CA3, and CA4/DG subfields in SZH only, but only at an uncorrected threshold.

These findings support the notion that hippocampal volumetric alteration contributes to memory impairment in SZH. In particular, findings point to the left CA1 subfield as being particularly important in this regard, informing potential targeted intervention strategies to address memory impairment and functional recovery in SZH.

immediate recall

delayed recall

thematic recall

schizophrenia

cognition

MRI

brain volume

© 2025 The Authors. Published by Elsevier B.V.