This review appraised 64 studies on just-in-time adaptive interventions (JITAIs) for adolescent precision health. JITAIs targeted diverse health conditions through adaptive mechanisms based on contextual mobile sensing data from adolescents. However, intervention and study designs were inconsistent, with limiting reporting of adolescent involvement and ethical considerations, hindering the strength and interpretability of findings. Guidelines co-created with adolescents emphasise the need for JITAIs that balance precise personalisation with adolescent agency.

The authors have declared no competing interest.

https://doi.org/10.1136/bmjopen-2024-083870

This research is funded by the Health & Technology Flagship programme, PROactive TEChnology-supported prevention and MEntal health in adolescence (PROTECt ME), as part of Convergence, the research alliance between Erasmus University Medical Center, Erasmus University Rotterdam, and Delft University of Technology. Additionally, KWG, CAF and MdR are supported through the High Tech for a Sustainable Future capacity building programme of the 4TU Federation in the Netherlands. 4TU Federation has no involvement in the development of this review or interpretation of its findings.

I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

Yes

I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals.

Yes

I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).

Yes

I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable.

Yes

All data produced in the present preprint are available upon reasonable request to the authors, and will be made publically available upon completion of peer-review.