Treatment of complex and chronic wounds often remains a challenge for clinicians, carrying a severe impact on the wellbeing of patients and the health care system. Leukocyte-and Platelet rich fibrin (L-PRF) is an autologous platelet product with regenerative properties that can be used to stimulate and accelerate wound healing. Its usage in oral surgery and dentistry is well established but evidence in urologic surgery is limited. We report two cases with extensive penile cutaneous defects after surgical debridement, treated with L-PRF technology and review the available literature regarding its utilization in the field of urology.

Platelet rich fibrin

Reconstructive urology

Regeneration

Urologic surgery

© 2025 The Authors. Published by Elsevier Inc.