Pancreatic Metastasis from Renal Cell Carcinoma Several Years after Nephrectomy: Two Case Reports and Literature Review

Metastases of renal cell carcinoma (RCC) to the pancreas are infrequent, comprising only 1 to 4% of pancreatic malignancies. These cases are distinguished by a prolonged period of being free from the disease following the initial surgery. We present here two rare cases of isolated pancreatic metastases from RCC, occurring 7 to 8 years after nephrectomy. The patients were asymptomatic; the masses were discovered incidentally during their routine annual health checkup. Surgical resection of these oligometastases was the appealing choice for managing these cases, potentially complemented by systemic treatment. The late onset of metastasis from RCC in solid organs should always be considered when dealing with patients with a history of RCC. Additionally, the follow-up following nephrectomy for RCC should be extended over 10 years.

renal cell carcinoma - pancreatic metastasis - pancreatectomy - metastasectomy - late onset

Case report approved for publishing by Ethical Committee at the Saint George Hospital University Medical Center, and Head of General Surgery Division.

All data were obtained from the patient for publication of this case report and accompanying images. All data are available for review by the Editor-in-Chief of this journal on request.

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

Bibliographical Record
Souad Ghattas, Jad El Bitar, Hani Maalouf, Tarek Bulbul, Omar Tabbikha, Wissam Dib, Antoine El Asmar, Hind Rahban, Ziad El Rassi. Pancreatic Metastasis from Renal Cell Carcinoma Several Years after Nephrectomy: Two Case Reports and Literature Review. Surg J (N Y) 2025; 11: a25914143.
DOI: 10.1055/a-2591-4143

Comments (0)

No login
gif