From Liquid SNEDDS to Solid SNEDDS: A Comprehensive Review of Their Development and Pharmaceutical Applications

Liu X, Zhao L, Wu B, Chen F. Improving solubility of poorly water-soluble drugs by protein-based strategy: a review. Int J Pharm. 2023;634:122704.

Article  CAS  PubMed  Google Scholar 

Thomas N, Holm R, Garmer M, Karlsson JJ, Müllertz A, Rades T. Supersaturated self-nanoemulsifying drug delivery systems (Super-SNEDDS) enhance the bioavailability of the poorly water-soluble drug simvastatin in dogs. AAPS J. 2013;15:219–27.

Article  CAS  PubMed  Google Scholar 

Morakul B. Self-nanoemulsifying drug delivery systems (SNEDDS): an advancement technology for oral drug delivery. Pharm Sci Asia. 2020;47:205–20.

Article  CAS  Google Scholar 

Chatterjee B, Hamed Almurisi S, Ahmed Mahdi Dukhan A, Mandal UK, Sengupta P. Controversies with self-emulsifying drug delivery system from pharmacokinetic point of view. Drug Deliv. 2016;23:3639–52.

Article  CAS  PubMed  Google Scholar 

Zafar A, Imam SS, Alruwaili NK, et al. Development of piperine-loaded solid self-nanoemulsifying drug delivery system: optimization, in-vitro, ex-vivo, and in-vivo evaluation. Nanomaterials. 2021;11:2920.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zingale E, Bonaccorso A, D’Amico AG, Lombardo R, D’Agata V, Rautio J, et al. Formulating resveratrol and melatonin self-nanoemulsifying drug delivery systems (SNEDDS) for ocular administration using design of experiments. Pharmaceutics. 2024;16:125.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tashish A, Shahba A, Alanazi F, Kazi M. Adsorbent precoating by lyophilization: a novel green solvent technique to enhance cinnarizine release from solid self-nanoemulsifying drug delivery systems (S-SNEDDS). Pharmaceutics. 2022;15:134.

Article  PubMed  PubMed Central  Google Scholar 

Ujilestari T, Martien R, Ariyadi B, Dono ND. Self-nanoemulsifying drug delivery system (SNEDDS) of Amomum compactum essential oil: design, formulation, and characterization. J Appl Pharm Sci. 2018;8:14–21.

Article  CAS  Google Scholar 

Kim JS, Din F ud, Lee SM, et al (2021) Comparison of Three Different Aqueous Microenvironments for Enhancing Oral Bioavailability of Sildenafil: Solid Self-Nanoemulsifying Drug Delivery System, Amorphous Microspheres and Crystalline Microspheres. Int J Nanomedicine Volume 16:5797–5810

Yasser M, Gad S, El-sayed M, Ghorab M. The effect of converting liquid valsartan SNEDDS into solid SNEDDS using different solid carriers on its performance. International Journal of Biological & Pharmaceutical Research. 2013;4:1015–26.

Google Scholar 

Alhakamy NA, Fahmy UA, Ahmed OAA, Almohammadi EA, Alotaibi SA, Aljohani RA, et al. Development of an optimized febuxostat self-nanoemulsified loaded transdermal film: in-vitro, ex-vivo and in-vivo evaluation. Pharm Dev Technol. 2020;25:326–31.

Article  CAS  PubMed  Google Scholar 

Rasoanirina BNV, Lassoued MA, Kamoun A, Bahloul B, Miladi K, Sfar S. Voriconazole-loaded self-nanoemulsifying drug delivery system (SNEDDS) to improve transcorneal permeability. Pharm Dev Technol. 2020;25:694–703.

Article  CAS  PubMed  Google Scholar 

Abushal AS, Aleanizy FS, Alqahtani FY, Shakeel F, Iqbal M, Haq N, et al. Self-nanoemulsifying drug delivery system (SNEDDS) of Apremilast. In vitro evaluation and pharmacokinetics studies. Molecules. 2022;27:3085.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rehman FU, Shah KU, Shah SU, Khan IU, Khan GM, Khan A. From nanoemulsions to self-nanoemulsions, with recent advances in self-nanoemulsifying drug delivery systems (SNEDDS). Expert Opin Drug Deliv. 2017;14:1325–40.

Article  PubMed  Google Scholar 

Akiladevi D, Prakash H, Biju G, Madumitha N. Nano-novel approach: self nano emulsifying drug delivery system (SNEDDS)-review article. Res J Pharm Technol. 2020;13:983.

Article  Google Scholar 

Buya AB, Beloqui A, Memvanga PB, Préat V. Self-nano-emulsifying drug-delivery systems: from the development to the current applications and challenges in oral drug delivery. Pharmaceutics. 2020;12:1194.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Galatage ST, Trivedi R, Bhagwat DA. Oral self-emulsifying nanoemulsion systems for enhancing dissolution, bioavailability and anticancer effects of camptothecin. J Drug Deliv Sci Technol. 2022;78:103929.

Article  CAS  Google Scholar 

Galatage ST, Manjappa AS, Salawi A, Desai JL, Kumbar VM, Ghagane S, et al. Palbociclib-letrozole loaded solid self-nano emulsifying drug delivery system for oral treatment of breast cancer: in-vitro and in-vivo characterization. J Drug Deliv Sci Technol. 2025;104:106469.

Article  CAS  Google Scholar 

Bertoni S, Albertini B, Passerini N. Different BCS class II drug-gelucire solid dispersions prepared by spray congealing: evaluation of solid state properties and in vitro performances. Pharmaceutics. 2020;12:548.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Uttreja P, Youssef AAA, Karnik I, Sanil K, Narala N, Wang H, et al. Formulation development of solid self-nanoemulsifying drug delivery systems of Quetiapine fumarate via hot-melt extrusion technology: optimization using central composite design. Pharmaceutics. 2024;16:324.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kulkarni VR, Bashyal S, Nair VV, Duggal I, Maniruzzaman M. Single-step extrusion process for formulation development of self-emulsifying granules for oral delivery of a BCS class IV drug. Mol Pharm. 2024;21:6123–36.

Article  CAS  PubMed  Google Scholar 

Hassan TH, Metz H, Mäder K. Novel semisolid SNEDDS based on PEG-30-dipolyhydroxystearate: development and characterization. Int J Pharm. 2014;477:506–18.

Article  CAS  PubMed  Google Scholar 

Sumirtapura YC, Pamudji JS, Mudhakir D, Suhery WN. Development and characterization of self-nanoemulsifying drug delivery system (SNEDDS) formulation for enhancing dissolution of fenofibric acid. J Res Pharm. 2020;24:738–47.

Google Scholar 

Anwer MK, Iqbal M, Aldawsari MF, Alalaiwe A, Ahmed MM, Muharram MM, et al. Improved antimicrobial activity and oral bioavailability of delafloxacin by self-nanoemulsifying drug delivery system (SNEDDS). J Drug Deliv Sci Technol. 2021;64:102572.

Article  CAS  Google Scholar 

Parmar K, Patel J, Sheth N. Self nano-emulsifying drug delivery system for Embelin: design, characterization and in-vitro studies. Asian J Pharm Sci. 2015;10:396–404.

Google Scholar 

Teaima M, Hababeh S, Khanfar M, Alanazi F, Alshora D, El-Nabarawi M. Design and Optimization of Pioglitazone Hydrochloride Self-Nanoemulsifying Drug Delivery System (SNEDDS) Incorporated into an Orally Disintegrating Tablet. Pharmaceutics. 2022;14:425.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Annisa R, Mutiah R, Yuwono M, Hendradi E. Nanotechnology approach-self nanoemulsifying drug delivery system (SNEDDS). Int J Appl Pharm. 2023; 12–19

Daar J, Khan A, Khan J, Khan A, Khan GM. Studies on self-nanoemulsifying drug delivery system of flurbiprofen employing long, medium and short chain triglycerides. Pak J Pharm Sci. 2017;30:601–6.

CAS  PubMed  Google Scholar 

Garg B, Beg S, Kaur R, Kumar R, Katare OP, Singh B. Long-chain triglycerides-based self-nanoemulsifying oily formulations (SNEOFs) of darunavir with improved lymphatic targeting potential. J Drug Target. 2018;26:252–66.

Article  CAS  PubMed  Google Scholar 

Schmied F-P, Bernhardt A, Engel A, Klein S. A customized screening tool approach for the development of a Self-Nanoemulsifying Drug Delivery System (SNEDDS). AAPS PharmSciTech. 2022;23:39.

Article  CAS  Google Scholar 

Schmied F-P, Bernhardt A, Klein S. Preparation of solid self-nanoemulsifying drug delivery systems (S-SNEDDS) by co-extrusion of liquid SNEDDS and polymeric carriers—a new and promising formulation approach to improve the solubility of poorly water-soluble drugs. Pharmaceuticals. 2022;15:1135.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Villar AMS, Naveros BC, Campmany ACC, Trenchs MA, Rocabert CB, Bellowa LH. Design and optimization of self-nanoemulsifying drug delivery systems (SNEDDS) for enhanced dissolution of gemfibrozil. Int J Pharm. 2012;431:161–75.

Article  CAS  PubMed  Google Scholar 

Farooqui H, Upadhyay S, Upadhyay P. Transdermal patches approach towards self-nano-emulsifying drug delivery system (SNEDDS) using essential oil as penetration enhancer. Micro Nanosyst. 2022;14:314–40.

Article  CAS 

Comments (0)

No login
gif