Tapas D, Sharmila B. Theranostic applications of Lutetium-177 in radionuclide therapy. Curr Radiopharm. 2016;9:94–101.
Filippi L, Chiaravalloti A, Schillaci O, Cianni R, Bagni O. Theranostic approaches in nuclear medicine: current status and future prospects. Expert Rev Med Devices. 2020;17:331–43.
Article CAS PubMed Google Scholar
Al-Ibraheem A, Mohamedkhair A. Current status of theranostics in Jordan. Nucl Med Mol Imaging. 2019;53:7–10.
Article CAS PubMed Google Scholar
Al-Ibraheem A, Scott AM, Abdlkadir AS, Vrachimis A, Lamoureux F, Trujillo PB, et al. Consensus nomenclature for radionuclide therapy: initial recommendations from nuclear medicine global initiative. J Nucl Med. 2025;66:757.
Habib SH, Saha S. Burden of non-communicable disease: global overview. Diabetes Metab Syndr. 2010;4(1):41–7.
Al-Ibraheem A, Zimmermann R, Abdlkadir AS, Herrmann K. Radiotheranostics global market and future developments. Semin Nucl Med. 2024;54:622–33.
Marzo RR, Bhattacharya S, Aye SS, Tripathi S, Naing TW, Soe MM, et al. Study on the quality of life among cancer survivors attending a tertiary care cancer center in Malaysia. J Public Health Res. 2022;11:2563.
Ministry of Health Malaysia. National Strategic Plan for Cancer Control Programme 2021–2025. 2021.https://www.moh.gov.my/moh/resources/Penerbitan/Rujukan/NCD/National_Strategic_Plan_for_Cancer_Control_Programme_2021-2025.pdf. Accessed 13 December 2024.
Al-Ibraheem A, Abdlkadir AS, Albalooshi B, Alkuwari M, Al Mahariq D, Al-Nabhani K, et al. Current status of theranostics in West asia: a country-based surveillance study. Nucl Med Mol Imaging. 2025;69:622–33.
Lin KH, Chen YW, Lee RC, Wang LW, Chou FI, Chang CW, et al. Nuclear theranostics in Taiwan. Nucl Med Mol Imaging. 2019;53:86–91.
Article CAS PubMed PubMed Central Google Scholar
Dadgar H, Norouzbeigi N, Assadi M, Jafari E, Al-Balooshi B, Al-Ibraheem A, et al. A prospective evaluation of chemokine receptor-4 (CXCR4) overexpression in high-grade glioma using ⁶⁸Ga-Pentixafor (Pars-Cixafor™) PET/CT imaging. Acad Radiol. 2025;32:2247–56.
Yang W, Kang F, Chen Y, Zhu Z, Wang F, Qin C, et al. Landscape of nuclear medicine in China and its progress on theranostics. J Nucl Med. 2024;65:S29–37.
Duan H, Iagaru A, Aparici CM. Radiotheranostics – precision medicine in nuclear medicine and molecular imaging. Nanotheranostics. 2022;6:103–17.
Article PubMed PubMed Central Google Scholar
International Atomic Energy Agency. Technical meeting on commercial products and services of research reactors- applications and services at PUSPATI TRIGA reactor in malaysia: current status and outlook. Vienna: IAEA; 2011.
Burkett BJ, Bartlett DJ, McGarrah PW, Lewis AR, Johnson DR, Berberoglu K, et al. A review of theranostics: perspectives on emerging approaches and clinical advancements. Radiol Imaging Cancer. 2023;5:220157.
Hasan S, Prelas MA. Molybdenum-99 production pathways and the sorbents for ⁹⁹Mo/⁹⁹Tc generator systems using (n, γ) ⁹⁹Mo: a review. SN Appl Sci. 2020;2:1782.
Dash A, Pillai MR, Knapp FF Jr. Production of ¹⁷⁷Lu for targeted radionuclide therapy: available options. Nucl Med Mol Imaging. 2015;49:85–107.
Article CAS PubMed PubMed Central Google Scholar
Fadzil MFA, Hasan S, Janib SNM, Kasbollah A, Wafa SAF. A survey on the usage and demand of medical radioisotope & radiopharmaceuticals in Malaysia. J Nucl Relat Technol. 2015;12:40–55.
Ashhar Z, Ahmad Fadzil MF, Hassan H, Othman MF, Md Hassan MB, Chun Vui VY, et al. The potential of radiolabeled bisphosphonates in SPECT and PET for bone imaging. Curr Med Imaging. 2024;20:e15734056270935.
Ashhar Z, Ahmad Fadzil MF, Md Safee Z, Aziz F, Ibarhim UH, Nik Afinde NMF, et al. Performance evaluation of Gallium-68 radiopharmaceuticals production using liquid target PETtrace 800 cyclotron. Appl Radiat Isot. 2024;205:111161.
Article CAS PubMed Google Scholar
Ashhar Z, Ahmad Fadzil MF, Othman MF, Yusof NA, Abdul Onny MA, Mat Ail N, et al. Cyclotron production of Gallium-68 radiopharmaceuticals using the ⁶⁸Zn(p,n)⁶⁸Ga reaction and their regulatory aspects. Pharmaceutics. 2023;15:70.
Hendrikse H, Kiss O, Kunikowska J, Wadsak W, Decristoforo C, Patt M. EANM position on the in-house preparation of radiopharmaceuticals. Eur J Nucl Med Mol Imaging. 2022;49:1095–8.
Said MA, Masud MA, Zaini MZ, Salleh RA, Lee BN, Zainon R. Lu-177 DOTATATE dosimetry for neuroendocrine tumor: single center experience. J Phys Conf Ser. 2017;851:012017.
Albert R, Smith-Jones P, Stolz B, Simeon C, Knecht H, Bruns C, et al. Direct synthesis of [DOTA-DPhe¹]-octreotide and [DOTA-DPhe¹, Tyr³]-octreotide (SMT487): two conjugates for systemic delivery of radiotherapeutical nuclides to somatostatin receptor positive tumors in man. Bioorg Med Chem Lett. 1998;8:1207–10.
Article CAS PubMed Google Scholar
Kubíček V, Havlíčková J, Kotek J, Tircsó G, Hermann P, Tóth É, et al. Gallium(III) complexes of DOTA and DOTA-monoamide: kinetic and thermodynamic studies. Inorg Chem. 2010;49:10960–9.
Breeman WAP, de Jong M, de Blois E, Bernard BF, Konijnenberg M, Krenning EP. Radiolabelling DOTA-peptides with ⁶⁸Ga. Eur J Nucl Med Mol Imaging. 2005;32:478–85.
Article CAS PubMed Google Scholar
Baum RP, Kulkarni HR. Theranostics: from molecular imaging using ⁶⁸Ga-labeled tracers and PET/CT to personalized radionuclide therapy – the bad Berka experience. Theranostics. 2012;2:437–47.
Article CAS PubMed PubMed Central Google Scholar
Werner RA, Bluemel C, Allen-Auerbach MS, Higuchi T, Herrmann K. ⁶⁸Gallium- and ⁹⁰Yttrium-/¹⁷⁷Lutetium: theranostic twins for diagnosis and treatment of NETs. Ann Nucl Med. 2015;29:1–7.
Article CAS PubMed Google Scholar
Kumar K, Chang CA, Francesconi LC, Dischino DD, Malley MF, Gougoutas JZ, et al. Synthesis, stability, and structure of gadolinium(III) and yttrium(III) macrocyclic poly(amino carboxylates). Inorg Chem. 1994;33:3567–75.
Viola-Villegas N, Doyle RP. The coordination chemistry of 1,4,7,10-tetraazacyclododecane-N,N′,N″,N′″-tetraacetic acid (H₄DOTA): structural overview and analyses on structure–stability relationships. Coord Chem Rev. 2009;253:1906–25.
Loncin MF, Desreux JF, Merciny E. Coordination of lanthanides by two polyamino polycarboxylic macrocycles: formation of highly stable lanthanide complexes. Inorg Chem. 1986;25:2646–8.
Clarke ET, Martell AE. Stabilities of trivalent metal ion complexes of the tetraacetate derivatives of 12-, 13- and 14-membered tetraazamacrocycles. Inorg Chim Acta. 1991;190:37–46.
Eder M, Wängler B, Knackmuss S, LeGall F, Little M, Haberkorn U, et al. Tetrafluorophenolate of HBED-CC: a versatile conjugation agent for ⁶⁸Ga-labeled small Recombinant antibodies. Eur J Nucl Med Mol Imaging. 2008;35:1878–86.
Article CAS PubMed Google Scholar
Eder M, Schäfer M, Bauder-Wüst U, Hull WE, Wängler C, Mier W, et al. ⁶⁸Ga-complex lipophilicity and the targeting property of a urea-based PSMA inhibitor for PET imaging. Bioconjug Chem. 2012;23:688–97.
Article CAS PubMed Google Scholar
Kularatne SA, Zhou Z, Yang J, Post CB, Low PS. Design, synthesis, and preclinical evaluation of prostate-specific membrane antigen targeted ⁹⁹Tc-radioimaging agents. Mol Pharm. 2009;6:790–800.
Article CAS PubMed PubMed Central Google Scholar
Price EW, Orvig C. Matching chelators to radiometals for radiopharmaceuticals. Chem Soc Rev. 2014;43:260–90.
Article CAS PubMed Google Scholar
Taliaferro CH, Martell A. New multidentate ligands. XXIV. Disodium-N,N′-bis(2-h
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