Liguo Wang is the Director of Scientific Operations at the Laboratory for BioMolecular Structure at Brookhaven National Laboratory. With a strong background in cryo-electron microscopy (cryo-EM), structural biology, and computer science, he codeveloped the ‘random spherically constrained’ cryo-EM method—originally proposed by Dr. Fred Sigworth—to study ion channels reconstituted in lipid vesicles under defined membrane potentials. His lab has resolved important membrane protein structures, including an intermediate state of the BK channel in a native-like membrane environment. Dr. Wang also contributed to artificial intelligence–driven cryo-EM tools and is advancing mega-electron-volt Scanning Transmission Electron Microscope (MeV-STEM) technology for imaging thick biological samples at nanometer resolution.