Abdulkhaleq MT, Rashid TA, Alsadoon A, Hassan BA, Mohammadi M, Abdullah JM, Chhabra A, Ali SL, Othman RN, Hasan HA, Azad S, Mahmood NA, Abdalrahman SS, Rasul HO, Bacanin N, Vimal S (2022) Harmony search: current studies and uses on healthcare systems. Artif Intell Med 131:102348. https://doi.org/10.1016/j.artmed.2022.102348
Al-Taweel A, Alqasoumi S, Alam P, Abdel-Kader M (2013) Densitometric-high-performance thin-layer chromatographic estimation of diosmin, hesperidin, and ascorbic acid in pharmaceutical formulations. JPC - J Planar Chromat 26:336–342. https://doi.org/10.1556/jpc.26.2013.4.8
Benavente-García O, Castillo J (2008) Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity. J Agric Food Chem 56:6185–6205. https://doi.org/10.1021/jf8006568
Article CAS PubMed Google Scholar
Berkoz M (2019) Diosmin suppresses the proinflammatory mediators in lipopolysaccharide-induced RAW264.7 macrophages via NF-κB and MAPKs signal pathways. Gen Physiol Biophys 38:315–324. https://doi.org/10.4149/gpb_2019010
Article CAS PubMed Google Scholar
Chen Y, Wang Y, Liu M, Zhou B, Yang G (2020) Diosmetin exhibits anti-proliferative and anti-inflammatory effects on TNF-α-stimulated human rheumatoid arthritis fibroblast-like synoviocytes through regulating the Akt and NF-κB signaling pathways. Phytother Res 34:1310–1319. https://doi.org/10.1002/ptr.6596
Article CAS PubMed Google Scholar
Cho EJ, Lee YG, Chang J, Bae HJ (2020) A high-yield process for production of biosugars and hesperidin from mandarin peel wastes. Molecules 25:4286. https://doi.org/10.3390/molecules25184286
Article CAS PubMed PubMed Central Google Scholar
de la Padilla Rosa JD, Ruiz-Palomino P, Arriola-Guevara E, García-Fajardo J, Sandoval G, Guatemala-Morales GM (2018) A green process for the extraction and purification of hesperidin from Mexican lime peel (Citrus aurantifolia Swingle) that is extendible to the Citrus genus. Processes 6:266. https://doi.org/10.3390/pr6120266
Ferraz CR, Carvalho TT, Manchope MF, Artero NA, Rasquel-Oliveira FS, Fattori V, Casagrande R, Verri WA Jr (2020) Therapeutic potential of flavonoids in pain and inflammation: mechanisms of action, pre-clinical and clinical data, and pharmaceutical development. Molecules 25:762. https://doi.org/10.3390/molecules25030762
Article CAS PubMed PubMed Central Google Scholar
Gervasi T, Patane GT, Calderaro A, Mandalari G, Barreca D (2023) Diosmin: advances on resources, biosynthesis pathway, bioavailability, bioactivity, and pharmacology. In: Xiao J (ed.) Handbook of dietary flavonoids. Springer, Cham. https://doi.org/10.1007/978-3-030-94753-8_7-1
Gopalakrishnan V, Iyyam Pillai S, Subramanian SP (2015) Synthesis, spectral characterization, and biochemical evaluation of antidiabetic properties of a new zinc-diosmin complex studied in high fat diet fed-low dose streptozotocin induced experimental type 2 diabetes in rats. Biochem Res Int 2015:350829. https://doi.org/10.1155/2015/350829
Article CAS PubMed PubMed Central Google Scholar
Huwait E, Mobashir M (2022) Potential and therapeutic roles of diosmin in human diseases. Biomedicines 10:1076. https://doi.org/10.3390/biomedicines10051076
Article CAS PubMed PubMed Central Google Scholar
Kokkirala S, Sabbavarapu NN, Yadavalli VDN (2010) Copper iodide as a recyclable catalyst for Buchwald N-arylation. Eur J Org Chem 2010:6678–6684. https://doi.org/10.1002/ejoc.201000964
Lopez Cremades FJ (2016) Interquim, S.A. Process for the preparation of diosmin. European patent application EP3053930 A1. Published 2016 Aug 10. Application No.: 15153537.4. Filed 2015 Feb 03. 053930A1. https://patents.google.com/patent/EP3053930A1/en
Manikyam HK, Ramesh C, Poluri KM, Assad A (2017) Microwave assisted subcritical water extraction of berberine hydrochloride from the roots of Berberis aristata using Harmony search algorithm. J Herb Med 2:19
Manikyam HK, Tripathi P, Patil SB, Lamichhane J, Chaitanya M, Patil AR (2020) Extraction, purification, and quantification of hesperidin from the immature Citrus grandis/maxima fruit Nepal cultivar. Asian J Nat Prod Biochem 20. https://doi.org/10.13057/biofar/f200105
Mustafa S, Akbar M, Khan MA, Sunita K, Parveen S, Pawar JS, Massey S, Agarwal NR, Husain SA (2022) Plant metabolite diosmin as the therapeutic agent in human diseases. Curr Res Pharmacol Drug Discov 3:100122. https://doi.org/10.1016/j.crphar.2022.100122
Article PubMed PubMed Central Google Scholar
Nguyen VT, Huynh T, Nguyen TD, Hoang T (2019) Oxidation of hesperidin into diosmin using ionic liquids. Org Commun 12:101–108. https://doi.org/10.25135/acg.oc.57.19.04.1242
Park SA, Bong SK, Lee JW, Park NJ, Choi Y, Kim SM, Yang MH, Kim YK, Kim SN (2020) Diosmetin and its glycoside, diosmin, improve atopic dermatitis-like lesions in 2,4-dinitrochlorobenzene-induced murine models. Biomol Ther 28:542–548. https://doi.org/10.4062/biomolther.2020.135
Pereira MM, Coutinho JAP, Freire MG (2016) Chapter 8: Ionic liquids as efficient tools for the purification of biomolecules and bioproducts from natural sources Check Access In: Bogel-Lukasik R (Ed.) Ionic liquids in the biorefinery concept: challenges and perspectives; The Royal Society of Chemistry. , Green Chemistry Seriespp. 227–257. https://doi.org/10.1039/9781782622598-00227
Rinaldi A, Zeno R, Peluso A, del Guercio L, Sodo M, Turchino D, Iandoli R, Costa D, Serra R, Bracale UM (2024) Efficacy of high-dose diosmin therapy in chronic venous disease treated with endovenous ablation: a quality-of-life analysis. J Vasc Dis 3:49–57. https://doi.org/10.3390/jvd3010004
Sakhardande R, Nimbalkar M, Khatri N, Patil S, Bhalekar S, Patil R, Firake P (2010) Process for the preparation of diosmin. PCT/IN2009/000717, WO 2010/092592 A2. https://patents.google.com/patent/WO2010092592A2/en
Serra R, Ielapi N, Bitonti A, Candido S, Fregola S, Gallo A, Loria A, Muraca L, Raimondo L, Velcean L, Guadagna S, Gallelli L (2021) Efficacy of a low-dose diosmin therapy on improving symptoms and quality of life in patients with chronic venous disease: randomized, double-blind, placebo-controlled trial. Nutrients 13:999. https://doi.org/10.3390/nu13030999
Article PubMed PubMed Central Google Scholar
Shaaban HH, Hozayen WG, Khaliefa AK, El-Kenawy AE, Ali TM, Ahmed OM (2022) Diosmin and trolox have anti-arthritic, anti-inflammatory and antioxidant potencies in complete Freund’s adjuvant-induced arthritic male Wistar rats: roles of NF-κB, iNOS, Nrf2 and MMPs. Antioxidants 11:1721. https://doi.org/10.3390/antiox11091721
Article CAS PubMed PubMed Central Google Scholar
Shawky E (2012) Development and validation of an HPTLC method for the simultaneous determination of diosmin and hesperidin in different citrus fruit extracts and pharmaceutical formulations. J Planar Chromatogr Mod TLC 25:138–144. https://doi.org/10.1556/jpc.25.2012.2.9
Tashrifi Z, Mohammadi Khanaposhtani M, Larijani B, Mahdavi M (2021) Recent advances in the oxidative conversion of benzylamines. Tetrahedron 84:131990. https://doi.org/10.1016/j.tet.2021.131990
Ventura SPM, Silva FA, Quental MV, Mondal D, Freire MG, Coutinho JAP (2017) Ionic-liquid-mediated extraction and separation processes for bioactive compounds: past, present, and future trends. Chem Rev 117:6984–7052. https://doi.org/10.1021/acs.chemrev.6b00550
Article CAS PubMed PubMed Central Google Scholar
Wang J, Ouyang H, Zhang C, Li S, Xiang J (2023) A novel intelligent global harmony search algorithm based on improved search stability strategy. Sci Rep 13:7705. https://doi.org/10.1038/s41598-023-34736-1
Article CAS PubMed PubMed Central Google Scholar
Wojciak M, Feldo M, Borowski G, Kubrak T, Płachno BJ, Sowa I (2022) Antioxidant potential of diosmin and diosmetin against oxidative stress in endothelial cells. Molecules 27:8232. https://doi.org/10.3390/molecules27238232
Article CAS PubMed PubMed Central Google Scholar
Zhaojun Z (2018) Qionglai. Inventor; Chengdu Okay Pharmaceutical Co., Ltd, assignee. European patent application EP 3 321 273 A1. 2018 May 16. https://patents.google.com/patent/EP3321273B1/en
Zou J, Yuan D, Yang J, Yu Y (2022) Effects of diosmin on vascular leakage and inflammation in a mouse model of venous obstruction. Front Nutr 9:831485. https://doi.org/10.3389/fnut.2022.831485
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