White matter microstructural alterations in chronic insomnia: an automated fiber quantification study linking diffusion changes to symptom severity
Purpose
Investigate white matter alterations in chronic insomnia (CI) using Automated Fiber Quantification (AFQ).
Methods
Diffusion tensor imaging data from 49 CI patients and 27 healthy controls were profiled for fractional anisotropy (FA), axial/mean/radial diffusivity (AD/MD/RD) across 100 nodes of 18 tracts.
Results
CI showed increased AD in bilateral anterior thalamic radiations, right inferior longitudinal fasciculus, right arcuate fasciculus; increased MD in bilateral anterior thalamic radiations, right corticospinal tract, forceps minor of the corpus callosum, and right inferior longitudinal fasciculus. Changes in specific segments correlated significantly with clinical scores.
Conclusions
AFQ reveals fiber-specific abnormalities linked to clinical scores in CI.
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