On-site Mass Spectrometry Detection of Exhaled Nitric Oxide Using Modified-Mask Sampling

Beauchamp J. Inhaled today, not gone tomorrow: pharmacokinetics and environmental exposure of volatiles in exhaled breath. J Breath Res. 2011;5:037103.

Article  CAS  PubMed  Google Scholar 

Das S, Pal M. Non-invasive monitoring of human health by exhaled breath analysis: a comprehensive review. J Electrochem Soc. 2020;167:037562.

Article  CAS  Google Scholar 

Zhou M, Liu Y, Duan Y. Breath biomarkers in diagnosis of pulmonary diseases. Clin Chim Acta. 2012;413:1770–80.

Article  CAS  PubMed  Google Scholar 

Lin W, Chen M, Chen Y, Hu W, Lin JM, Xing G. Recent progress of point-of-care testing of volatile organic compounds. J Anal Test. 2025;10:58–82.

Article  Google Scholar 

Xiong S, Xiao R, Wei C, Zhang L, Lv Y. Advances in cataluminescence-based sensors for environmental pollutant detection. J Anal Test. 2025;9:504–22.

Article  CAS  Google Scholar 

Hu B. Mass spectrometric analysis of exhaled breath: recent advances and future perspectives. TrAC Trends Anal Chem. 2023;168:117320.

Article  CAS  Google Scholar 

Su R, Yang T, Zhang X, Li N, Zhai X, Chen H. Mass spectrometry for breath analysis. TrAC Trends Anal Chem. 2023;158:116823.

Article  CAS  Google Scholar 

Kharitonov SA, Barnes PJ. Biomarkers of some pulmonary diseases in exhaled breath. Biomarkers. 2002;7:1–32.

Article  CAS  PubMed  Google Scholar 

Kharitonov SA, Barnes PJ. Exhaled markers of pulmonary disease. Am J Respir Crit Care Med. 2001;163:1693–722.

Article  CAS  PubMed  Google Scholar 

Choi J, Hoffman LA, Rodway GW, Sethi JM. Markers of lung disease in exhaled breath: nitric oxide. Biol Res Nurs. 2006;7:241–55.

Article  CAS  PubMed  Google Scholar 

Malerba M, Radaeli A, Olivini A, Damiani G, Ragnoli B, Montuschi P, et al. Exhaled nitric oxide as a biomarker in COPD and related comorbidities. Biomed Res Int. 2014;1: 271918.

Google Scholar 

Robbins RA, Floreani AA, Von Essen SG, Sisson JH, Hill GE, Rubinstein I, et al. Measurement of exhaled nitric oxide by three different techniques. Am J Respir Crit Care Med. 1996;153:1631–5.

Article  CAS  PubMed  Google Scholar 

Cristescu S, Mandon J, Harren F, Meriläinen P, Högman M. Methods of NO detection in exhaled breath. J Breath Res. 2013;7:017104.

Article  CAS  PubMed  Google Scholar 

Barnes PJ, Dweik RA, Gelb AF, Gibson PG, George SC, Grasemann H, et al. Exhaled nitric oxide in pulmonary diseases: a comprehensive review. Chest. 2010;138:682–92.

Article  CAS  PubMed  Google Scholar 

Cristescu SM, Marchenko D, Mandon J, Hebelstrup K, Griffith GW, Mur LAJ, et al. Spectroscopic monitoring of NO traces in plants and human breath: applications and perspectives. Appl Phys B. 2013;110:203–11.

Article  CAS  Google Scholar 

Li C, Chen X, Li W, Zhou X, Gong H. A non-invasive lung disease study of exhaled breath nitric oxide based on ultraviolet differential absorption spectroscopy techniques. J Biophotonics. 2025;18:e202400481.

Article  CAS  PubMed  Google Scholar 

Wang C, Sahay P. Breath analysis using laser spectroscopic techniques: breath biomarkers, spectral fingerprints, and detection limits. Sensors. 2009;9:8230–62.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Henderson B, Khodabakhsh A, Metsälä M, Ventrillard I, Schmidt FM, Romanini D, Ritchie GAD, te Lintel Hekkert S, Briot R, Risby T, Marczin N, Harren FJM, Cristescu SM. Laser spectroscopy for breath analysis: towards clinical implementation. Appl Phys B. 2018;124:161.

Article  PubMed  PubMed Central  Google Scholar 

Bruderer T, Gaisl T, Gaugg MT, Nowak N, Streckenbach B, Müller S, Moeller A, Kohler M, Zenobi R. On-line analysis of exhaled breath. Chem Rev. 2019;119:10803–28.

Article  CAS  PubMed  Google Scholar 

Cao W, Duan Y. Current status of methods and techniques for breath analysis. Crit Rev Anal Chem. 2007;37:3–13.

Article  CAS  Google Scholar 

Huang H, Yang J, Tao C, Hu L, Huan T, Zhang W, et al. Exhaled breath analysis of non-volatile drugs: towards clinical applications. TrAC - Trends Anal Chem. 2024;171:117541.

Article  CAS  Google Scholar 

Kim KH, Jahan SA, Kabir E. A review of breath analysis for diagnosis of human health. TrAC - Trends Anal Chem. 2012;33:1–8.

Article  Google Scholar 

Li W, Liu X, Hu B. Robotic technologies for environmental mass spectrometry: recent advances and perspectives. TrAC - Trends Anal Chem. 2026;195:118614.

Article  CAS  Google Scholar 

Xie Y, You L, Wang X, Zhang Y, Wang Z, Li L, et al. Miniature mass spectrometry in drug and food analysis: bridging laboratory and field applications. TrAC - Trends Anal Chem. 2026;195:118594.

Article  CAS  Google Scholar 

Li W, Liu X, Hu B. Robotic technologies for environmental mass spectrometry: recent advances and perspectives. TrAC - Trends Anal Chem. 2026;118614:118614.

Article  Google Scholar 

Cao J, Jiang T, Xu W. Miniature mass spectrometry for VOCs analysis: recent developments in instrumentation and applications. Rapid Commun Mass Spectrom. 2025;39:e10088.

Article  CAS  PubMed  Google Scholar 

Liu X, Liu X, Li B, Zhang X, Hu B. Lab-on-Robot: unmanned mass spectrometry robot for direct sample analysis in hazardous and radioactive environments. Anal Chem. 2025;97:9126–30.

Article  CAS  PubMed  Google Scholar 

Yang F, Liang Z, Zhao H, Zheng J, Liu L, Song H, et al. Mass spectral database-based methodologies for the annotation and discovery of natural products. Chin J Nat Med. 2025;23:410–20.

PubMed  Google Scholar 

Liu X, Hu B. Mask device as a new wearable sampler for breath analysis: what can we expect in the future? Anal Bioanal Chem. 2023;415:3759–68.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tse HT, Yu JZ, Cai Z, Chan W. Disposable face masks for noninvasive drug detection: a proof-of-concept study with cough syrup constituents. Anal Chem. 2025;97:10424–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yuan ZC, Li W, Wu L, Huang D, Wu M, Hu B. Solid-phase microextraction fiber in face mask for in vivo sampling and direct mass spectrometry analysis of exhaled breath aerosol. Anal Chem. 2020;92:11543–7.

Article  CAS  PubMed  Google Scholar 

Heng W, Yin S, Min J, Wang C, Han H, Shirzaei SE, et al. A smart mask for exhaled breath condensate harvesting and analysis. Science. 2024;385:954–61.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu B. Recent advances in facemask devices for in vivo sampling of human exhaled breath aerosols and inhalable environmental exposures. TrAC Trends Anal Chem. 2022;151:116600.

Article  CAS  Google Scholar 

Cai SH, Di D, Yuan ZC, Chen W, Hu B. Paper-in-facemask device for direct mass spectrometry analysis of human respiratory aerosols and environmental exposures via wearable continuous-flow adsorptive sampling: a proof-of-concept study. Anal Chem. 2021;93:13743–8.

Article  CAS  PubMed 

Comments (0)

No login
gif