Pediatric lymphomas: overview and diagnostic challenges

Leukemia & Lymphoma Society (2023) https://www.lls.org/booklet/facts-updated-data-blood-cancers. Accessed 30 Jun 2024

Proytcheva MA (2011) Diagnostic pediatric hematopathology. Cambridge University Press, Cambridge, New York

Book  Google Scholar 

Simonin M, Jardin F, Leblanc T, Latour S, Landman Parker J (2023) An update on molecular features and therapeutic perspectives of pediatric classical Hodgkin lymphoma. What the clinician needs to know? Eur J Med Genet 66:104672. https://doi.org/10.1016/j.ejmg.2022.104672

Article  PubMed  Google Scholar 

Lee J, Han JH, Lee CH, Park HS, Min SK, Lee H, Cho U, Yoon SE, Kim SJ, Kim WS, Cho J (2023) Comparison of histological and molecular features of pediatric-type follicular lymphoma and pediatric nodal marginal zone lymphoma. Virchows Arch 482:849–858. https://doi.org/10.1007/s00428-023-03493-x

Article  CAS  PubMed  Google Scholar 

Britto TI, Fattah SA, Rahman MAU, Chowdhury MAU (2023) A systematic review on childhood non-Hodgkin lymphoma: an overlooked phenomenon in the health and research sector of Bangladesh. Cureus 15:e45937. https://doi.org/10.7759/cureus.45937

Article  PubMed  PubMed Central  Google Scholar 

Attarbaschi A, Abla O, Arias Padilla L, Beishuizen A, Burke GAA, Brugieres L, Bruneau J, Burkhardt B, d’Amore ESG, Klapper W, Kontny U, Pillon M, Taj M, Turner SD, Uyttebroeck A, Woessmann W, Mellgren K (2020) Rare non-Hodgkin lymphoma of childhood and adolescence: a consensus diagnostic and therapeutic approach to pediatric-type follicular lymphoma, marginal zone lymphoma, and nonanaplastic peripheral T-cell lymphoma. Pediatr Blood Cancer 67:e28416. https://doi.org/10.1002/pbc.28416

Article  PubMed  Google Scholar 

Thomas N, Dreval K, Gerhard DS, Hilton LK, Abramson JS, Ambinder RF, Barta S, Bartlett NL, Bethony J, Bhatia K, Bowen J, Bryan AC, Cesarman E, Casper C, Chadburn A, Cruz M, Dittmer DP, Dyer MA, Farinha P, Gastier-Foster JM, Gerrie AS, Grande BM, Greiner T, Griner NB, Gross TG, Harris NL, Irvin JD, Jaffe ES, Henry D, Huppi R, Leal FE, Lee MS, Martin JP, Martin MR, Mbulaiteye SM, Mitsuyasu R, Morris V, Mullighan CG, Mungall AJ, Mungall K, Mutyaba I, Nokta M, Namirembe C, Noy A, Ogwang MD, Omoding A, Orem J, Ott G, Petrello H, Pittaluga S, Phelan JD, Ramos JC, Ratner L, Reynolds SJ, Rubinstein PG, Sissolak G, Slack G, Soudi S, Swerdlow SH, Traverse-Glehen A, Wilson WH, Wong J, Yarchoan R, ZenKlusen JC, Marra MA, Staudt LM, Scott DW, Morin RD (2023) Genetic subgroups inform on pathobiology in adult and pediatric Burkitt lymphoma. Blood 141:904–916. https://doi.org/10.1182/blood.2022016534

Article  CAS  PubMed  Google Scholar 

Phan TDA, Duong TT, Thi Nhu Pham D, Hoang Dang M, Thanh Ly T, Thi Tuyet Ngo H, Ngo DQ, Trinh NDT, Le Ly U, Anh Thai T, Thi Ngoc Hua H, Thi Phuong Doan T (2023) A Multicenter study of clinicopathology and immunohistochemical distinction between adult and pediatric large B-cell lymphoma. Fetal Pediatr Pathol 42:355–366. https://doi.org/10.1080/15513815.2022.2120786

Article  CAS  PubMed  Google Scholar 

El-Mallawany NK, Alexander S, Fluchel M, Hayashi RJ, Lowe EJ, Giulino-Roth L, Wistinghausen B, Hermiston M, Allen CE, Committee CN (2023) Children’s Oncology Group’s 2023 blueprint for research: non-Hodgkin lymphoma. Pediatr Blood Cancer 70(Suppl 6):e30565. https://doi.org/10.1002/pbc.30565

Article  PubMed  PubMed Central  Google Scholar 

Castellino SM, Giulino-Roth L, Harker-Murray P, Kahn JM, Forlenza C, Cho S, Hoppe B, Parsons SK, Kelly KM, Committee COGHL (2023) Children’s Oncology Group’s 2023 blueprint for research: Hodgkin lymphoma. Pediatr Blood Cancer 70(Suppl 6):e30580. https://doi.org/10.1002/pbc.30580

Article  PubMed  PubMed Central  Google Scholar 

Ohki K, Kiyokawa N, Watanabe S, Iwafuchi H, Nakazawa A, Ishiwata K, Ogata-Kawata H, Nakabayashi K, Okamura K, Tanaka F, Fukano R, Hata K, Mori T, Moriya Saito A, Hayashi Y, Taga T, Sekimizu M, Japan Children’s Cancer Study G (2021) Characteristics of genetic alterations of peripheral T-cell lymphoma in childhood including identification of novel fusion genes: the Japan Children’s Cancer Group (JCCG). Br J Haematol 194:718–729. https://doi.org/10.1111/bjh.17639

Article  CAS  PubMed  Google Scholar 

Au-Yeung RKH, Richter J, Iaccarino I, Abramov D, Bacon CM, Balague O, d’Amore ESG, Simonitsch-Klupp I, Hebeda K, Nakazawa A, Oschlies I, Kontny U, Woessmann W, Burkhardt B, Klapper W (2021) Molecular features of non-anaplastic peripheral T-cell lymphoma in children and adolescents. Pediatr Blood Cancer 68:e29285. https://doi.org/10.1002/pbc.29285

Article  CAS  PubMed  Google Scholar 

Alaggio R, Hasle, H (2022) Haematolymphoid disorders. In: WHO classification of tumours editorial board. Paediatric tumours [Internet]. WHO classification of tumours series. https://tumourclassification.iarc.who.int/chapters/44. Accessed 6/30/2024 2024

(2024) WHO classification of tumours editorial board. Haematolymphoid tumours [Internet]. WHO classification of tumours series. https://tumourclassification.iarc.who.int/chapters/63. Accessed 6/30/2024 2024

Campo E, Jaffe ES, Cook JR, Quintanilla-Martinez L, Swerdlow SH, Anderson KC, Brousset P, Cerroni L, de Leval L, Dirnhofer S, Dogan A, Feldman AL, Fend F, Friedberg JW, Gaulard P, Ghia P, Horwitz SM, King RL, Salles G, San-Miguel J, Seymour JF, Treon SP, Vose JM, Zucca E, Advani R, Ansell S, Au WY, Barrionuevo C, Bergsagel L, Chan WC, Cohen JI, d’Amore F, Davies A, Falini B, Ghobrial IM, Goodlad JR, Gribben JG, Hsi ED, Kahl BS, Kim WS, Kumar S, LaCasce AS, Laurent C, Lenz G, Leonard JP, Link MP, Lopez-Guillermo A, Mateos MV, Macintyre E, Melnick AM, Morschhauser F, Nakamura S, Narbaitz M, Pavlovsky A, Pileri SA, Piris M, Pro B, Rajkumar V, Rosen ST, Sander B, Sehn L, Shipp MA, Smith SM, Staudt LM, Thieblemont C, Tousseyn T, Wilson WH, Yoshino T, Zinzani PL, Dreyling M, Scott DW, Winter JN, Zelenetz AD (2022) The international consensus classification of mature lymphoid neoplasms: a report from the clinical advisory committee. Blood 140:1229–1253. https://doi.org/10.1182/blood.2022015851

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jeha S, Choi J, Roberts KG, Pei D, Coustan-Smith E, Inaba H, Rubnitz JE, Ribeiro RC, Gruber TA, Raimondi SC, Karol SE, Qu C, Brady SW, Gu Z, Yang JJ, Cheng C, Downing JR, Evans WE, Relling MV, Campana D, Mullighan CG, Pui CH (2021) Clinical significance of novel subtypes of acute lymphoblastic leukemia in the context of minimal residual disease-directed therapy. Blood Cancer Discov 2:326–337. https://doi.org/10.1158/2643-3230.BCD-20-0229

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li JF, Dai YT, Lilljebjorn H, Shen SH, Cui BW, Bai L, Liu YF, Qian MX, Kubota Y, Kiyoi H, Matsumura I, Miyazaki Y, Olsson L, Tan AM, Ariffin H, Chen J, Takita J, Yasuda T, Mano H, Johansson B, Yang JJ, Yeoh AE, Hayakawa F, Chen Z, Pui CH, Fioretos T, Chen SJ, Huang JY (2018) Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases. Proc Natl Acad Sci U S A 115:E11711–E11720. https://doi.org/10.1073/pnas.1814397115

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brady SW, Roberts KG, Gu Z, Shi L, Pounds S, Pei D, Cheng C, Dai Y, Devidas M, Qu C, Hill AN, Payne-Turner D, Ma X, Iacobucci I, Baviskar P, Wei L, Arunachalam S, Hagiwara K, Liu Y, Flasch DA, Liu Y, Parker M, Chen X, Elsayed AH, Pathak O, Li Y, Fan Y, Michael JR, Rusch M, Wilkinson MR, Foy S, Hedges DJ, Newman S, Zhou X, Wang J, Reilly C, Sioson E, Rice SV, Pastor Loyola V, Wu G, Rampersaud E, Reshmi SC, Gastier-Foster J, Guidry Auvil JM, Gesuwan P, Smith MA, Winick N, Carroll AJ, Heerema NA, Harvey RC, Willman CL, Larsen E, Raetz EA, Borowitz MJ, Wood BL, Carroll WL, Zweidler-McKay PA, Rabin KR, Mattano LA, Maloney KW, Winter SS, Burke MJ, Salzer W, Dunsmore KP, Angiolillo AL, Crews KR, Downing JR, Jeha S, Pui CH, Evans WE, Yang JJ, Relling MV, Gerhard DS, Loh ML, Hunger SP, Zhang J, Mullighan CG (2022) The genomic landscape of pediatric acute lymphoblastic leukemia. Nat Genet 54:1376–1389. https://doi.org/10.1038/s41588-022-01159-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kroeze E, Iaccarino I, Kleisman MM, Mondal M, Beder T, Khouja M, Hoppner MP, Scheijde-Vermeulen MA, Kester LA, Bruggemann M, Baldus CD, Cario G, Bladergroen RS, Garnier N, Attarbaschi A, Verdu-Amoros J, Sutton R, Macintyre EA, Scholten K, Arias Padilla L, Burkhardt B, Beishuizen A, den Boer ML, Kuiper RP, Loeffen JLC, Boer JM, Klapper W (2024) Mutational and transcriptional landscape of pediatric B-cell precursor lymphoblastic lymphoma. Blood. https://doi.org/10.1182/blood.2024023938

Article  PubMed  Google Scholar 

Termuhlen AM, Smith LM, Perkins SL, Lones M, Finlay JL, Weinstein H, Gross TG, Abromowitch M (2012) Outcome of newly diagnosed children and adolescents with localized lymphoblastic lymphoma treated on Children’s Oncology Group trial A5971: a report from the Children’s Oncology Group. Pediatr Blood Cancer 59:1229–1233. https://doi.org/10.1002/pbc.24149

Article  PubMed  PubMed Central  Google Scholar 

Forlenza CJ, Chadburn A, Giulino-Roth L (2023) Primary mediastinal B-cell lymphoma in children and young adults. J Natl Compr Canc Netw 21:323–330. https://doi.org/10.6004/jnccn.2023.7004

Article  CAS  PubMed  Google Scholar 

Huibers M, Abla O, Andres M, Balague O, Beishuizen A, Carraro E, Chiang A, Csoka M, David BA, de Ville de Goyet M, Gilad G, Hori D, Kotecha RS, Kabickova E, Klapper W, Miakova N, Minard-Colin V, Nakazawa A, Pillon M, Rigaud C, Salaverria I, Tolle I, Verdu-Amoros J, von Mersi H, Wossmann W, Burkhardt B, Attarbaschi A (2024) Large B-cell lymphoma-IRF4+ in children and young people: time to reduce chemotherapy in a rare malignant mature B-cell neoplasm? Blood Adv 8:1509-1514. https://doi.org/10.1182/bloodadvances.2023012109

Au-Yeung RKH, Arias Padilla L, Zimmermann M, Oschlies I, Siebert R, Woessmann W, Burkhardt B, Klapper W (2020) Experience with provisional WHO-entities large B-cell lymphoma with IRF4-rearrangement and Burkitt-like lymphoma with 11q aberration in paediatric patients of the NHL-BFM group. Br J Haematol 190:753–763. https://doi.org/10.1111/bjh.16578

Article  CAS  PubMed  Google Scholar 

Dorfman DM, Shahsafaei A, Alonso MA (2012) Utility of CD200 immunostaining in the diagnosis of primary mediastinal large B cell lymphoma: comparison with MAL, CD23, and other markers. Mod Pathol 25:1637–1643. https://doi.org/10.1038/modpathol.2012.129

Article  CAS  PubMed  Google Scholar 

Gentry M, Bodo J, Durkin L, Hsi ED (2017) Performance of a commercially available MAL antibody in the diagnosis of primary mediastinal large B-cell lymphoma. Am J Surg Pathol 41:189–194. https://doi.org/10.1097/PAS.0000000000000771

Article  PubMed  Google Scholar 

Shi M, Roemer MG, Chapuy B, Liao X, Sun H, Pinkus GS, Shipp MA, Freeman GJ, Rodig SJ (2014) Expression of programmed cell death 1 ligand 2 (PD-L2) is a distinguishing feature of primary mediastinal (thymic) large B-cell lymphoma and associated with PDCD1LG2 copy gain. Am J Surg Pathol 38:1715–1723. https://doi.org/10.1097/PAS.0000000000000297

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