Gatta G, Capocaccia R, Botta L et al (2017) RARECAREnet working group. Burden and centralised treatment in Europe of rare tumours results of RARECAREnet-a population-based study. Lancet Oncol 18:1022–1039
Fassnacht M, Assie G, Baudin E et al (2020) Adrenocortical carcinomas and malignant phaeochromocytomas: ESMO-EURACAN clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 31:1476–1490
Article CAS PubMed Google Scholar
Averbuch SD, Steakley CS, Young RC et al (1988) Malignant pheochromocytoma: effective treatment with a combination of cyclophosphamide, vincristine, and dacarbazine. Ann Intern Med 109:267–273
Article CAS PubMed Google Scholar
Niemeijer ND, Alblas G, van Hulsteijn LT et al (2014) Chemotherapy with cyclophosphamide, vincristine and dacarbazine for malignant paraganglioma and pheochromocytoma: systematic review and meta-analysis. Clin Endocrinol 81:642–651
Huang H, Abraham J, Hung E et al (2008) Treatment of malignant pheochromocytoma/paraganglioma with cyclophosphamide, vincristine, and dacarbazine: recommendation from a 22-year follow-up of 18 patients. Cancer 113:2020–2028
Article CAS PubMed Google Scholar
Baudin E, Goichot B, Berruti A et al (2024) Sunitinib for metastatic progressive phaeochromocytomas and paragangliomas: results from FIRSTMAPPP, an academic, multicentre, international, randomised, placebo-controlled, double-blind, phase 2 trial. Lancet 403:1061–1070
Article CAS PubMed Google Scholar
Fishbein L, Leshchiner I, Walter V et al (2017) Comprehensive molecular characterization of pheochromocytoma and paraganglioma. Cancer Cell 31:181–193
Article CAS PubMed PubMed Central Google Scholar
Amar L, Bertherat J, Baudin E et al (2005) Genetic testing in pheochromocytoma or functional paraganglioma. J Clin Oncol 23:8812–8818
Article CAS PubMed Google Scholar
Neumann HP, Pawlu C, Peczkowska M et al (2004) Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations. JAMA 292:943–951
Article CAS PubMed Google Scholar
Taïeb D, Nölting S, Perrier ND et al (2024) Management of phaeochromocytoma and paraganglioma in patients with germline SDHB pathogenic variants: an international expert Consensus statement. Nat Rev Endocrinol 20:168–184
van Nederveen FH, Gaal J, Favier J et al (2009) An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis. Lancet Oncol 10:764–771
Article PubMed PubMed Central Google Scholar
Mete O, Pakbaz S, Lerario AM et al (2021) Significance of alpha-inhibin expression in pheochromocytomas and paragangliomas. Am J Surg Pathol 45:1264–1273
Naing A, Meric-Bernstam F, Stephen B et al (2020) Phase 2 study of pembrolizumab in patients with advanced rare cancers. J Immunother Cancer 8:e000347
Article PubMed PubMed Central Google Scholar
Tufton N, Hearnden RJ, Berney DM et al (2022) The immune cell infiltrate in the tumour microenvironment of phaeochromocytomas and paragangliomas. Endocr Relat Cancer 29:589–598
CAS PubMed PubMed Central Google Scholar
Celada L, Cubiella T, San-Juan-Guardado J et al (2023) Pseudohypoxia in paraganglioma and pheochromocytoma is associated with an immunosuppressive phenotype. J Pathol 259:103–114
Article CAS PubMed Google Scholar
Fujiwara Y, Ohmoto A, Fukuda N et al (2021) Clinical features and outcomes of metastatic pheochromocytoma treated by cytotoxic chemotherapy. Endocr J 68:671–681
Article CAS PubMed Google Scholar
Yu A, Xu X, Pang Y et al (2023) PD-L1 Expression is Linked to Tumor-Infiltrating T-Cell Exhaustion and Adverse Pathological Behavior in Pheochromocytoma/Paraganglioma. Lab Invest 103:100210
Kimura N, Takayanagi R, Takizawa N et al (2014) Phaeochromocytoma Study Group in Japan. Pathological grading for predicting metastasis in phaeochromocytoma and paraganglioma. Endocr Relat Cancer 21:405–414
Baniak N, Flood TA, Buchanan M et al (2020) Carbonic anhydrase IX (CA9) expression in multiple renal epithelial tumour subtypes. Histopathology 77:659–666
Shigematsu Y, Amori G, Tanaka K et al (2023) MHC class I loss is associated with biliary/progenitor cell features and “cold” tumor-immune microenvironment in hepatocellular carcinoma. Virchows Arch 483:177–186
Article CAS PubMed Google Scholar
Herbst RS, Baas P, Kim DW et al (2016) Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial. Lancet 387:1540–1550
Article CAS PubMed Google Scholar
Shigematsu Y, Inamura K, Yamamoto N et al (2018) Impact of CDX2 expression status on the survival of patients after curative resection for colorectal cancer liver metastasis. BMC Cancer 18:980
Article CAS PubMed PubMed Central Google Scholar
Shigematsu Y, Amori G, Kanda H et al (2022) Decreased ARG1 expression as an adverse prognostic phenotype in non-alcoholic non-virus-related hepatocellular carcinoma. Virchows Arch 481:253–263
Article CAS PubMed Google Scholar
Kanda Y (2013) Investigation of the freely available easy-to-use software “EZR” for medical statistics. Bone Marrow Transplant 48:452–458
Article CAS PubMed Google Scholar
Li H, Abbas KS, Abdelazeem B et al (2022) A Predictive nomogram for early death in pheochromocytoma and paraganglioma. Front Oncol 12:770958
Article PubMed PubMed Central Google Scholar
Koh JM, Ahn SH, Kim H et al (2017) Validation of pathological grading systems for predicting metastatic potential in pheochromocytoma and paraganglioma. PLoS One 12:e0187398
Article PubMed PubMed Central Google Scholar
Guo D, Zhao X, Wang A et al (2019) PD-L1 expression and association with malignant behavior in pheochromocytomas/paragangliomas. Hum Pathol 86:155–162
Article CAS PubMed Google Scholar
Ghosal S, Hadrava Vanova K et al (2023) Immune signature of pheochromocytoma and paraganglioma in context of neuroendocrine neoplasms associated with prognosis. Endocrine 79:171–179
Article CAS PubMed Google Scholar
Goswami KK, Bose A, Baral R (2021) Macrophages in tumor: An inflammatory perspective. Clin Immunol 232:108875
Article CAS PubMed Google Scholar
Fishbein L, Khare S, Wubbenhorst B et al (2015) Whole-exome sequencing identifies somatic ATRX mutations in pheochromocytomas and paragangliomas. Nat Commun 6:6140
Article CAS PubMed Google Scholar
Calsina B, Piñeiro-Yáñez E, Martínez-Montes ÁM et al (2023) Genomic and immune landscape of metastatic pheochromocytoma and paraganglioma. Nat Commun 14:1122
Article CAS PubMed PubMed Central Google Scholar
D’Angelo F, Ceccarelli M, Tala, et al (2019) The molecular landscape of glioma in patients with Neurofibromatosis 1. Nat Med 25:176–187
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