Gastrodin Alleviates Lumbar Intervertebral Disc Degeneration by Suppressing the NF-κB and MAPK Pathways

Khan, A. N., Jacobsen, H. E., Khan, J., Filippi, C. G., Levine, M., Lehman, R. A., Riew, K. D., Lenke, L. G. & Chahine, N. O. (2017). Inflammatory biomarkers of low back pain and disc degeneration: a review. Annals of the New York Academy of Sciences, 1410(1), 68–84.

Article  PubMed  PubMed Central  Google Scholar 

Cieza, A., Causey, K., Kamenov, K., Hanson, S. W., Chatterji, S., & Vos, T. (2021). Global estimates of the need for rehabilitation based on the Global Burden of Disease study 2019: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet, 396(10267), 2006–2017.

Article  Google Scholar 

Buchbinder, R., van Tulder, M., Öberg, B., Costa, L. M., Woolf, A., Schoene, M., Croft, P., & Lancet Low Back Pain Series Working, G. (2018). Low back pain: a call for action. The Lancet, 391(10137), 2384–2388.

Article  Google Scholar 

Vergroesen, P. P., Kingma, I., Emanuel, K. S., Hoogendoorn, R. J., Welting, T. J., van Royen, B. J., van Dieën, J. H., & Smit, T. H. (2015). Mechanics and biology in intervertebral disc degeneration: a vicious circle. Osteoarthritis and Cartilage, 23(7), 1057–1070.

Article  PubMed  Google Scholar 

Kamali, A., Ziadlou, R., Lang, G., Pfannkuche, J., Cui, S., Li, Z., Richards, R. G., Alini, M., & Grad, S. (2021). Small molecule-based treatment approaches for intervertebral disc degeneration: Current options and future directions. Theranostics, 11(1), 27–47.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Binch, A. L. A., Fitzgerald, J. C., Growney, E. A. & Barry, F. (2021). Cell-based strategies for IVD repair: clinical progress and translational obstacles. Nature Reviews Rheumatology, 17(3), 158–175.

Article  PubMed  Google Scholar 

Liu, K., Wei, J., Li, G., Liu, R., Zhao, D., Zhang, Y., Shi, J., Xie, Q. & Cheng, L. (2021). Fexofenadine protects against intervertebral disc degeneration through TNF signaling. Frontiers in Cell and Developmental Biology, 9, 687024.

Article  PubMed  PubMed Central  Google Scholar 

Molinos, M., Almeida, C. R., Caldeira, J., Cunha, C., Gonçalves, R. M. & Barbosa, M. A. (2015). Inflammation in intervertebral disc degeneration and regeneration. Journal of the Royal Society Interface, 12(104), 20141191.

Article  PubMed  PubMed Central  Google Scholar 

Liang, H., Luo, R., Li, G., Zhang, W., Song, Y. & Yang, C. (2022). The proteolysis of ECM in intervertebral disc degeneration. International Journal of Molecular Sciences, 23(3), 1715.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Navone, S. E., Marfia, G., Giannoni, A., Beretta, M., Guarnaccia, L., Gualtierotti, R., Nicoli, D., Rampini, P. & Campanella, R. (2017). Inflammatory mediators and signalling pathways controlling intervertebral disc degeneration. Histology & Histopathology, 32(6), 523–542.

CAS  Google Scholar 

Wang, Q., Chen, G. & Zeng, S. (2008). Distribution and metabolism of gastrodin in rat brain. Journal of Pharmaceutical and Biomedical Analysis, 46(2), 399–404.

Article  PubMed  CAS  Google Scholar 

Wong, S. B., Hung, W. C. & Min, M. Y. (2016). The role of gastrodin on hippocampal neurons after N-methyl-D-aspartate excitotoxicity and experimental temporal lobe seizures. Chinese Journal of Physiology, 59(3), 156–164.

Article  PubMed  CAS  Google Scholar 

Liu, Y., Gao, J., Peng, M., Meng, H., Ma, H., Cai, P., Xu, Y., Zhao, Q. & Si, G. (2018). A review on central nervous system effects of gastrodin. Frontiers in Pharmacology, 9, 24.

Article  PubMed  PubMed Central  Google Scholar 

Xiao, M. M., Zhang, Y. Q., Wang, W. T., Han, W. J., Lin, Z., Xie, R. G., Cao, Z., Lu, N., Hu, S. J., Wu, S. X., Dong, H. & Luo, C. (2016). Gastrodin protects against chronic inflammatory pain by inhibiting spinal synaptic potentiation. Scientific Reports, 6, 37251.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wan, J., Zhang, Y., Yang, D., Liang, Y., Yang, L., Hu, S., Liu, Z., Fang, Q., Tian, S., & Ding, Y. (2021). Gastrodin improves nonalcoholic fatty liver disease through activation of the adenosine monophosphate-activated protein kinase signaling pathway. Hepatology, 74(6), 3074–3090.

Article  PubMed  CAS  Google Scholar 

Huang, L., Shao, M. & Zhu, Y. (2022). Gastrodin inhibits high glucose-induced inflammation, oxidative stress and apoptosis in podocytes by activating the AMPK/Nrf2 signaling pathway. Experimental and Therapeutic Medicine, 23(2), 168.

Article  PubMed  CAS  Google Scholar 

Ma, J. Q., Sun, Y. Z., Ming, Q. L., Tian, Z. K., Zhang, Y. J. & Liu, C. M. (2020). Effects of gastrodin against carbon tetrachloride induced kidney inflammation and fibrosis in mice associated with the AMPK/Nrf2/HMGB1 pathway. Food & Function, 11(5), 4615–4624.

Article  Google Scholar 

Du, F., Wang, X., Shang, B., Fang, J., Xi, Y., Li, A. & Diao, Y. (2016). Gastrodin ameliorates spinal cord injury via antioxidant and anti-inflammatory effects. Acta Biochimica Polonica, 63(3), 589–593.

Article  PubMed  CAS  Google Scholar 

Liu, S., Zhou, L., Yang, L., Mu, S., Fang, T., & Fu, Q. (2018). Gastrodin alleviates glucocorticoid induced osteoporosis in rats via activating the Nrf2 signaling pathways. Oncotarget, 9(14), 11528–11540.

Article  PubMed  PubMed Central  Google Scholar 

Wang, Y., Che, M., Xin, J., Zheng, Z., Li, J. & Zhang, S. (2020). The role of IL-1β and TNF-α in intervertebral disc degeneration. Biomedicine & Pharmacotherapy, 131, 110660.

Article  CAS  Google Scholar 

Wang, C., Yu, X., Yan, Y., Yang, W., Zhang, S., Xiang, Y., Zhang, J. & Wang, W. (2017). Tumor necrosis factor-α: a key contributor to intervertebral disc degeneration. Acta Biochimica et Biophysica Sinica, 49(1), 1–13.

Article  PubMed  Google Scholar 

Zhang, G. Z., Liu, M. Q., Chen, H. W., Wu, Z. L., Gao, Y. C., Ma, Z. J., He, X. G. & Kang, X. W. (2021). NF-κB signalling pathways in nucleus pulposus cell function and intervertebral disc degeneration. Cell Proliferation, 54(7), e13057.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhang, H. J., Liao, H. Y., Bai, D. Y., Wang, Z. Q. & Xie, X. W. (2021). MAPK /ERK signaling pathway: A potential target for the treatment of intervertebral disc degeneration. Biomedicine & Pharmacotherapy, 143, 112170.

Article  CAS  Google Scholar 

Ye, F., Xu, Y., Lin, F. & Zheng, Z. (2021). TNF-α suppresses SHOX2 expression via NF-κB signaling pathway and promotes intervertebral disc degeneration and related pain in a rat model. Journal of Orthopaedic Research, 39(8), 1745–1754.

Article  PubMed  CAS  Google Scholar 

Wang, X. H., Hong, X., Zhu, L., Wang, Y. T., Bao, J. P., Liu, L., Wang, F. & Wu, X. T. (2015). Tumor necrosis factor alpha promotes the proliferation of human nucleus pulposus cells via nuclear factor-κB, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase. Experimental Biology and Medicine (Maywood), 240(4), 411–417.

Article  CAS  Google Scholar 

Wang, J., Hu, J., Chen, X., Huang, C., Lin, J., Shao, Z., Gu, M., Wu, Y., Tian, N., Gao, W., Zhou, Y., Wang, X. & Zhang, X. (2019). BRD4 inhibition regulates MAPK, NF-κB signals, and autophagy to suppress MMP-13 expression in diabetic intervertebral disc degeneration. The FASEB Journal, 33(10), 11555–11566.

Article  PubMed  CAS  Google Scholar 

Liao, Z., Wu, X., Song, Y., Luo, R., Yin, H., Zhan, S., Li, S., Wang, K., Zhang, Y. & Yang, C. (2019). Angiopoietin-like protein 8 expression and association with extracellular matrix metabolism and inflammation during intervertebral disc degeneration. Journal of Cellular and Molecular Medicine, 23(8), 5737–5750.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zheng, Y., Lin, Y., Chen, Z., Jiao, Y., Yuan, Y., Li, C., Xu, X. & Cao, P. (2018). Propionibacterium acnes induces intervertebral discs degeneration by increasing MMP-1 and inhibiting TIMP-1 expression via the NF-κB pathway. International Journal of Clinical and Experimental Pathology, 11(7), 3445–3453.

PubMed  PubMed Central  Google Scholar 

Liu, G. Z., Ishihara, H., Osada, R., Kimura, T., & Tsuji, H. (2001). Nitric oxide mediates the change of proteoglycan synthesis in the human lumbar intervertebral disc in response to hydrostatic pressure. Spine (Phila Pa 1976), 26(2), 134–141.

Article  PubMed  CAS  Google Scholar 

Jiang, Y., Wu, H., Peng, Y., He, P., Qian, S., Lin, H., Chen, H., Qian, R., Wang, D., Chu, M., Ji, W., Guo, X. & Shan, X. (2024). Gastrodin ameliorates acute pancreatitis by modulating macrophage inflammation cascade via inhibition the p38/NF-κB pathway. International Immunopharmacology, 129, 111593.

Article  PubMed  CAS 

Comments (0)

No login
gif