SCI Abstract

search
+
Doxorubicin-Induced Cardiotoxicity: Molecular Mechanisms to Novel Therapeutic Frontiers of Recent Preclinical Discoveries
Doxorubicin-Induced Cardiotoxicity: Molecular Mechanisms to Novel Therapeutic Frontiers of Recent Preclinical Discoveries
Cardiotoxicity is the most common side effect of various chemotherapy medications. Doxorubicin (DOX), which belongs to the...
Extracellular levels of glutamate, glutamine, cystine, glutathione, and xanthine correlate with transporter expression in tamoxifen - resistant MCF-7 cells and poor overall survival in breast cancer patients
Extracellular levels of glutamate, glutamine, cystine, glutathione, and xanthine correlate with transporter expression in tamoxifen - resistant MCF-7 cells and poor overall survival in breast cancer patients
Tamoxifen resistance development in breast cancer cells is a major clinical challenge. Metabolic alterations play a fundam...
attenuates hepatic fibrosis in mice by suppressing hepatic stellate cells activation and modulating inflammatory chemokine signaling
attenuates hepatic fibrosis in mice by suppressing hepatic stellate cells activation and modulating inflammatory chemokine signaling
Hepatic fibrosis is a chronic and progressive liver disease that can lead to cirrhosis or hepatocellular carcinoma. It rep...
Enhancing the Efficacy of Paclitaxel with Nano-Activators: A Novel Approach to Mitigating the Chemotherapies Side-Effects
Enhancing the Efficacy of Paclitaxel with Nano-Activators: A Novel Approach to Mitigating the Chemotherapies Side-Effects
In the modern era of medical science, nanotechnology plays a pivotal role in drug repurposing, remodelling, novel drug del...
Optimization of Non-Cross-Linked Hyaluronic Acid and Adipose-Derived Mesenchymal Stem Cells for Regenerative Applications: an in Vitro Study
Optimization of Non-Cross-Linked Hyaluronic Acid and Adipose-Derived Mesenchymal Stem Cells for Regenerative Applications: an in Vitro Study
Hyaluronic acid (HA) and adipose-derived mesenchymal stem cells (AD-MSCs) are both promising agents for skin rejuvenation....
Synthesis of Apolipoprotein A-I in Human Macrophages Enhances their Migratory Activity
Synthesis of Apolipoprotein A-I in Human Macrophages Enhances their Migratory Activity
Apolipoprotein A-I (ApoA-I) is the major structural and functional protein of high density lipoprotein (HDL) particles. Ap...
Chemical Epigenetics: Small Molecules Targeting Chromatin Modifiers in Disease Modulation
Chemical Epigenetics: Small Molecules Targeting Chromatin Modifiers in Disease Modulation
Epigenetic regulation controls gene expression through reversible chromatin modifications, including DNA methylation, hist...
Naringin Potentiates Docetaxel-Induced Apoptosis in Breast Cancer Cells via Transient Interaction with the TUBB3 GTP-Binding Site
Naringin Potentiates Docetaxel-Induced Apoptosis in Breast Cancer Cells via Transient Interaction with the TUBB3 GTP-Binding Site
Breast cancer (BC) is associated with the overexpression of tubulin isotypes, promoting malignant progression and poor pro...
Amino Acids as Targets for Immunotherapy against Solid Tumors
Amino Acids as Targets for Immunotherapy against Solid Tumors
The metabolism of tumor cells exerts a great influence on the tumor microenvironment (TME) of solid tumors and antitumor i...
Anti-Photoaging Activity of a Structurally Optimized Curcumin Analogue (THHGV-5) in UV-B-Irradiated Human Dermal Fibroblasts: An Integrated In Silico and In Vitro Study
Anti-Photoaging Activity of a Structurally Optimized Curcumin Analogue (THHGV-5) in UV-B-Irradiated Human Dermal Fibroblasts: An Integrated In Silico and In Vitro Study
Ultraviolet-B (UV-B) radiation is a major extrinsic factor driving skin photoaging through excessive oxidative stress, mat...
Peroxiredoxins in the Developmental Origins of Health and Disease: Insights from Maternal Under and Overnutrition – A Critical-Interpretative Scoping Review
Peroxiredoxins in the Developmental Origins of Health and Disease: Insights from Maternal Under and Overnutrition – A Critical-Interpretative Scoping Review
Epidemiological and experimental evidence indicate that disturbances during pregnancy or lactation can induce metabolic pr...
Epithelial Barrier Dysfunction in Down Syndrome: A Gateway to Chronic Lung Injury?
Epithelial Barrier Dysfunction in Down Syndrome: A Gateway to Chronic Lung Injury?
Down syndrome, also known as trisomy 21, is associated with an increased risk of respiratory morbidity disproportionate to...
Investigation of the Anticancer Potential of Thai Blue Sponge via Targeting the PI3K/AKT/SRC Signaling Pathway using Molecular Docking and Dynamic Stimulation
Investigation of the Anticancer Potential of Thai Blue Sponge via Targeting the PI3K/AKT/SRC Signaling Pathway using Molecular Docking and Dynamic Stimulation
Renieramycins are tetrahydroisoquinoline alkaloids derived from marine blue sponge Xestospongia. They have biological acti...
FGFRL1 Modulates Glucose-Glycogen Homeostasis and Signaling Pathway Genes to Suppress Chemoresistance in Esophageal Carcinoma
FGFRL1 Modulates Glucose-Glycogen Homeostasis and Signaling Pathway Genes to Suppress Chemoresistance in Esophageal Carcinoma
Chemoresistance remains a significant barrier to the treatment of esophageal cancer (EC), regulated by metabolic and signa...
Non-Titanised Compared to Titanised Polypropylene Meshes Induce a Pro-Inflammatory and Anti-Angiogenic Response in Fibroblast Co-Cultures
Non-Titanised Compared to Titanised Polypropylene Meshes Induce a Pro-Inflammatory and Anti-Angiogenic Response in Fibroblast Co-Cultures
Pelvic organs prolapse (POP) can be treated surgically with native tissue or by placing mesh implants in the pelvic floor ...
Integrating Experimental Assays, Preclinical Models, and CRISPR-Based Functional Approaches for Cancer Drug Discovery
Integrating Experimental Assays, Preclinical Models, and CRISPR-Based Functional Approaches for Cancer Drug Discovery
Effective cancer drug discovery requires experimental strategies that integrate mechanistic insight with clinical relevanc...
Single-Cell Transcriptomic Integration Identifies LTA4H as an Immune-Associated Therapeutic Target in Hepatocellular Carcinoma
Single-Cell Transcriptomic Integration Identifies LTA4H as an Immune-Associated Therapeutic Target in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) remains one of the leading causes of cancer-related mortality worldwide, with limited effec...
Bone and Cardiometabolic Connection: Crosstalk between Osteoporosis and Atherosclerosis
Bone and Cardiometabolic Connection: Crosstalk between Osteoporosis and Atherosclerosis
The crosstalk between osteoporosis and atherosclerosis has gained substantial attention due to the shared risk factors and...
Pathogenic Proteins Through the Lens of NMR Spectroscopy: Structural and Functional Insights into Disease
Pathogenic Proteins Through the Lens of NMR Spectroscopy: Structural and Functional Insights into Disease
Proteins are essential for cell functions, and their dysfunction—including misfolding, aggregation, abnormal interac...
Inducing Oxidative Stress-Driven Senescent Phenotype in Induced Pluripotent Stem Cell Derived Cardiomyocytes
Inducing Oxidative Stress-Driven Senescent Phenotype in Induced Pluripotent Stem Cell Derived Cardiomyocytes
Cardiovascular diseases (CVDs) pose a significant health challenge, particularly among aging populations. Age-related cell...
as a Model for Reprogramming of Eukaryotic Cells: Implications for the Study of the Relationship Between Metabolism and Inflammation in Chronic Disease
as a Model for Reprogramming of Eukaryotic Cells: Implications for the Study of the Relationship Between Metabolism and Inflammation in Chronic Disease
Inflammation is a fundamental feature of many diseases. It is part of a programmed response to threats concerning an organ...
The Pharmacological Spectrum of Hispidulin: A Thorough Systematic Review and Meta-analysis
The Pharmacological Spectrum of Hispidulin: A Thorough Systematic Review and Meta-analysis
Phytochemicals have historically played a crucial role in promoting health and well-being. Hispidulin, a plant-derived met...
Repurposing Alkaloids as Allosteric PTP 1B Inhibitors: Computational Profiling and Biochemical Validation
Repurposing Alkaloids as Allosteric PTP 1B Inhibitors: Computational Profiling and Biochemical Validation
Protein-tyrosine phosphatase 1B (PTP 1B) is a validated antihyperglycaemic target whose chemical space remains sparsely po...
Unlocking the Secrets of Nature: Phytochemicals as Key Players in Longevity and Healthy Aging
Unlocking the Secrets of Nature: Phytochemicals as Key Players in Longevity and Healthy Aging
The global aging population presents significant health and societal challenges, driven by age-related disorders including...
Bioisosteric and Virtual Screening Approach to Identify Natural Inhibitors of nsP3
Bioisosteric and Virtual Screening Approach to Identify Natural Inhibitors of nsP3
Chikungunya fever is an arboviral disease characterized by high fever, rash, and intense polyarthralgia, which may persist...
Identification and Analysis of the Protective Role of Exosomes Derived from Umbilical Cord Mesenchymal Stem Cells in Sepsis-induced Intestinal Injury by Bioinformatics and Experimental Verification
Identification and Analysis of the Protective Role of Exosomes Derived from Umbilical Cord Mesenchymal Stem Cells in Sepsis-induced Intestinal Injury by Bioinformatics and Experimental Verification
Sepsis is a systemic inflammatory response that often leads to multiple-organ dysfunction, particularly intestinal injury,...
6-Methoxydihydrosanguinarine Suppresses the Proliferation of Non-small Cell Lung Cancer Cells through Elevation of ROS and Activation of IRE1/JNK Signaling
6-Methoxydihydrosanguinarine Suppresses the Proliferation of Non-small Cell Lung Cancer Cells through Elevation of ROS and Activation of IRE1/JNK Signaling
Lung cancer is the leading cause of cancer-related mortality worldwide, highlighting the novel therapeutic strategies for ...
The Ketogenic Diet in Obesity Management: Friend or Foe?
The Ketogenic Diet in Obesity Management: Friend or Foe?
Obesity remains a leading global health challenge, driving a surge in dietary interventions aimed at effective weight loss...
Harnessing Statistical and Machine Learning Approaches to Analyze Oxidized LDL in Clinical Research
Harnessing Statistical and Machine Learning Approaches to Analyze Oxidized LDL in Clinical Research
Oxidized low-density lipoprotein (OxLDL) is increasingly recognized as a critical mediator in the pathogenesis of atherosc...
Phosphorylation Enhanced the anti-cancer Therapeutic Activity of -derived Arabinogalactan in Hepatocellular Carcinoma
Phosphorylation Enhanced the anti-cancer Therapeutic Activity of -derived Arabinogalactan in Hepatocellular Carcinoma
Cancer is one of the major health concern, underscoring the need for the development of potent anticancer therapeutic agen...
Load More
format_indent_increase