Yang J, Li H, Zhao Y (2023) Dessert or Poison? The roles of glycosylation in Alzheimer’s, Parkinson’s, Huntington’s disease, and Amyotrophic lateral sclerosis. ChemBioChem 24(16):e202300017

Kousparou C, Fyrilla M, Stephanou A, Patrikios I (2023) DHA/EPA (omega-3) and LA/GLA (Omega-6) as bioactive molecules in neurodegenerative diseases. Int J Mol Sci 24:10717

CAS  PubMed  PubMed Central  Google Scholar 

Fischer R, Maier O (2015) Interrelation of oxidative stress and inflammation in neurodegenerative disease: role of TNF. Oxid Med Cell Longev 2015(1):610813

PubMed  PubMed Central  Google Scholar 

Leszek J, Barreto G, Gąsiorowski K, Koutsouraki E, Ávila-Rodrigues M, Aliev G (2016) Inflammatory mechanisms and oxidative stress as key factors responsible for progression of neurodegeneration: role of brain innate immune system. CNS Neurol Disord Drug Targets 15(3):329–336

CAS  PubMed  Google Scholar 

Nguyen TD, Dang LN, Jang JH, Park S (2023) Recent advances in Alzheimer’s disease pathogenesis and therapeutics from an immune perspective. J Pharm Investig 53:667–684

Google Scholar 

Simpson D, Oliver P (2020) ROS generation in microglia: understanding oxidative stress and inflammation in neurodegenerative disease. Antioxidants 9(8):743

CAS  PubMed  PubMed Central  Google Scholar 

Guo C, Sun L, Chen X, Zhang D (2013) Oxidative stress, mitochondrial damage and neurodegenerative diseases. Neural Regen Res 8:2003–2014

CAS  PubMed  PubMed Central  Google Scholar 

Vaiwala, R., Ayappa, K.G., 2023. Martini-3 coarse-grained models for the bacterial lipopolysaccharide outer membrane of Escherichia coli. J Chem Theory Comput 37676287

Mu R, Dong L, Wang C (2023) Carbohydrates as putative pattern recognition receptor agonists in vaccine development. Trends Immunol 44:845–857

CAS  PubMed  Google Scholar 

Dabi YT, Ajagbe AO, Degechisa ST (2023) Toll-like receptors in pathogenesis of neurodegenerative diseases and their therapeutic potential. Immun Inflamm Dis 11:e839

CAS  PubMed  PubMed Central  Google Scholar 

Lee H, Han JH, An K, Kang YJ, Hwangbo H, Heo JH, Choi BH, Kim JJ et al (2023) Recombinant human KAI1/CD82 attenuates M1 macrophage polarization on LPS-stimulated RAW264.7 cells via blocking TLR4/JNK/NF-κB signal pathway. BMB Rep 56:359–364

CAS  PubMed  PubMed Central  Google Scholar 

Shabani M, Erfani S, Abdolmaleki A, Afzali FE, Khoshnazar SM (2023) Alpha-pinene modulates inflammatory response and protects against brain ischemia via inducible nitric oxide synthase-nuclear factor–kappa B-cyclooxygenase-2 pathway. Mol Biol Rep 50:6505–6516

CAS  PubMed  Google Scholar 

Dludla PV, Mabhida SE, Ziqubu K, Nkambule BB, Mazibuko-Mbeje SE, Hanser S, Basson AK, Pheiffer C et al (2023) Pancreatic β-cell dysfunction in type 2 diabetes: implications of inflammation and oxidative stress. World J Diabetes 14:PMC10075035

Google Scholar 

Abdelhamid RF, Nagano S (2023) Crosstalk between oxidative stress and aging in neurodegeneration disorders. Cells 12:753

CAS  PubMed  PubMed Central  Google Scholar 

Liu J, Duan W, Deng Y, Zhang Q, Li R, Long J, Ahmed W, Gu C et al (2023) New insights into molecular mechanisms underlying neurodegenerative disorders. J Integr Neurosci 22:58

PubMed  Google Scholar 

Mangrulkar SV, Wankhede NL, Kale MB, Upaganlawar AB, Taksande BG, Umekar MJ, Anwer MK, Dailah HG et al (2023) Mitochondrial dysfunction as a signaling target for therapeutic intervention in major neurodegenerative disease. Neurotox Res 41:708–729

CAS  PubMed  Google Scholar 

Dembitsky VM, Gloriozova TA, Poroikov VV (2015) Naturally occurring plant isoquinoline N-oxide alkaloids: their pharmacological and SAR activities. Phytomedicine 22(1):183–202

CAS  PubMed  Google Scholar 

Plazas E, Muñoz DR (2022) Natural isoquinoline alkaloids: pharmacological features and multi-target potential for complex diseases. Pharmacol Res 177:106126

CAS  PubMed  Google Scholar 

Shang XF, Yang CJ, Morris-Natschke SL, Li JC, Yin XD, Liu YQ, Guo X, Peng JW et al (2020) Biologically active isoquinoline alkaloids covering 2014–2018. Med Res Rev 40(6):2212–2289

CAS  PubMed  PubMed Central  Google Scholar 

Yun D, Yoon SY, Park SJ, Park YJ (2021) The anticancer effect of natural plant alkaloid isoquinolines. Int J Mol Sci 22(4):1653

CAS  PubMed  PubMed Central  Google Scholar 

Zhang Q, Jiang Q, Sa K, Liang J, Sun D, Li H, Chen L (2023) Research progress of plant-derived natural alkaloids in central nervous system diseases. Phytother Res 37:4885–4907

PubMed  Google Scholar 

Li J, Wu Y, Dong S, Yu Y, Wu Y, Xiang B, Li Q (2023) Research progress on neuroprotective effects of isoquinoline alkaloids. Molecules 28:4797

CAS  PubMed  PubMed Central  Google Scholar 

Olufunmilayo EO, Gerke-Duncan MB, Holsinger RD (2023) Oxidative stress and antioxidants in neurodegenerative disorders. Antioxidants 12:517

CAS  PubMed  PubMed Central  Google Scholar 

Plascencia-Villa G, Perry G (2023) Roles of oxidative stress in synaptic dysfunction and neuronal cell death in Alzheimer’s disease. Antioxidants 12:1628

CAS  PubMed  PubMed Central  Google Scholar 

Kooshki L, Zarneshan SN, Fakhri S, Morardi SZ, Echeverria J (2023) The pivotal role of JAK/STAT and IRS/PI3K signaling pathways in neurodegenerative diseases: mechanistic approaches to polyphenols and alkaloids. Phytomedicine 112:154686

CAS  PubMed  Google Scholar 

Bhusal CK, Uti DE, Mukherjee D, Alqahtani T, Alqahtani S, Bhattacharya A, Akash S (2023) Unveiling nature’s potential: promising natural compounds in Parkinson’s disease management. Parkinsonism Relat Disord 115:105799

CAS  PubMed  Google Scholar 

Yang Y, Ding T, Xiao G, Huang J, Luo D, Yue M, Su Y, Jiang S et al (2023) Anti-inflammatory effects of Allocryptopine via the target on the CX3CL1–CX3CR1 axis/GNB5/AKT/NF-κB/apoptosis in dextran sulfate-induced mice. Biomedicines 11:464

Niğdelioğlu Dolanbay S, Kocanci FG, Aslim B (2021) Neuroprotective effects of allocryptopine-rich alkaloid extracts against oxidative stress-induced neuronal damage. Biomed Pharmacother 140:111690

PubMed  Google Scholar 

Niğdelioğlu Dolanbay S, Şirin S, Aslim B (2023) Cocktail of three isoquinoline alkaloids derived from Glaucium grandiflorum Boiss. & A. Huet subsp. refractum (Nábelek) Mory inhibits the production of LPS-induced ROS, pro-inflammatory cytokines, and mediators through the downregulation of p38 MAPK in BV-2 cells. Fitoterapia 170:105652

Wilson DM, Cookson MR, Van Den Bosch L, Zetterberg H, Holtzman DM, Dewachter I (2023) Hallmarks of neurodegenerative diseases. Cell 186:693–714

CAS  PubMed  Google Scholar 

Rehman MU, Sehar N, Dar NJ, Khan A, Arafah A, Rashid S, Rashid SM, Ganaies MA (2023) Mitochondrial dysfunctions, oxidative stress and neuroinflammation as therapeutic targets for neurodegenerative diseases: An update on current advances and impediments. Neurosci Biobehav Rev 144:104961

CAS  PubMed  Google Scholar 

Korovesis D, Rubio-Tomás T, Tavernarakis N (2023) Oxidative stress in age-related neurodegenerative diseases: an overview of recent tools and findings. Antioxidants 12:131

CAS  PubMed  PubMed Central  Google Scholar 

Boleti APDA, Cardoso PHDO, Frihling BEF, Silva PSE, de Moraes LFRN, Migliolo L (2023) Adipose tissue, systematic inflammation, and neurodegenerative diseases. Neural Regen Res 18:38–46

Google Scholar 

Lo J, Wu HE, Liu CC, Chang KC, Lee PY, Liu PL, Huang SP, Wu PC et al (2023) Nordalbergin exerts anti-neuroinflammatory effects by attenuating MAPK signaling pathway, NLRP3 inflammasome activation and ROS production in LPS-stimulated BV2 microglia. Int J Mol Sci 24:7300

CAS  PubMed  PubMed Central  Google Scholar 

He D, Fu S, Ye B, Wang H, He Y, Li Z, Li J, Gao X et al (2023) Activation of HCA2 regulates microglial responses to alleviate neurodegeneration in LPS-induced in vivo and in vitro models. J Neuroinflammation 20:86

CAS  PubMed  PubMed Central  Google Scholar 

Verma A, Azhar G, Zhang X, Patyal P, Kc G, Sharma S, Che Y, Wei JY (2023) P. gingivalis-LPS induces mitochondrial dysfunction mediated by neuroinflammation through oxidative stress. Int J Mol Sci 24:950

CAS  PubMed  PubMed Central  Google Scholar 

Payne A, Taka E, Adinew GM, Soliman KFA (2023) Molecular mechanisms of the anti-inflammatory effects of epigallocatechin 3-gallate (EGCG) in LPS-activated BV-2 microglia cells. Brain Sci 13:632

CAS  PubMed  PubMed Central  Google Scholar 

Walker A, Czyz DM (2023) Oh my gut! Is the microbial origin of neurodegenerative diseases real? Infect Immun 91:e00437-e522

PubMed  PubMed Central  Google Scholar 

Niğdelioğlu Dolanbay S, Sirin S, Aslim B (2023) Neuroprotective potential of isoquinoline alkaloids from Glaucium grandiflorum Boiss. and A. Huet subsp. refractum (Nábelek) Mory: role of NRF2-KEAP1 pathway. App Sci 13:11205

Sirin S, Dolanbay SN, Aslim B (2023) Role of plant derived alkaloids as antioxidant agents for neurodegenerative diseases. Health Sci Rev 6:100071

Google Scholar 

Nigdelioglu Dolanbay S, Sirin S, Aslim B (2024) Neuroprotection induced by plant alkaloids. In Natural Molecules in Neuroprotection and Neurotoxicity. Academic Press, pp 1159–1195