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Brain-Derived Exosomes in Neurodevelopmental and Neuropsychiatric Disorders: Molecular Insights, Therapeutic Potential, and Translational Challenges
Brain-Derived Exosomes in Neurodevelopmental and Neuropsychiatric Disorders: Molecular Insights, Therapeutic Potential, and Translational Challenges
Neurodevelopmental disorders (NDDs), including autism spectrum disorders, attention-deficit hyperactivity disorders, schiz...
DDX3X Aggravates Neuronal Pyroptosis and Inhibits Autophagy via NLRP3 Inflammasome After Experimental Subarachnoid Hemorrhage
DDX3X Aggravates Neuronal Pyroptosis and Inhibits Autophagy via NLRP3 Inflammasome After Experimental Subarachnoid Hemorrhage
Neuronal cell death is considered the symbol of early brain injury after subarachnoid hemorrhage (SAH), but the mechanism ...
An Exploratory Analysis of Differential Tear Fluid miRNAs in Patients with Parkinson’s Disease and Atypical Parkinsonian Syndromes
An Exploratory Analysis of Differential Tear Fluid miRNAs in Patients with Parkinson’s Disease and Atypical Parkinsonian Syndromes
Parkinson’s disease (PD), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP) are neurodegenerat...
Downregulation of Glycogen Synthase Kinase-3 Beta by L. Contributes to Neuroprotection Against Aluminum Chloride-Mediated Neurotoxicity in Zebrafish Larvae
Downregulation of Glycogen Synthase Kinase-3 Beta by L. Contributes to Neuroprotection Against Aluminum Chloride-Mediated Neurotoxicity in Zebrafish Larvae
Urtica dioica L. (U. dioica; Family Urticaceae) has been utilized since ancient times, both as a nutritional source and fo...
s KM71H Attenuates Cognitive Deficits and Depressive-Like Behavior by the TLR4/NF-κB Signaling Pathway in an Aβ-Induced AD-Like Mouse Model
s KM71H Attenuates Cognitive Deficits and Depressive-Like Behavior by the TLR4/NF-κB Signaling Pathway in an Aβ-Induced AD-Like Mouse Model
Komagataella pastoris is a promising probiotic for modulating the microbiota-gut-brain axis, and growing evidence has demo...
Correction: Multi-Target Inhibitor of ZJQ- 3 F Against AChE/BACE1/GSK3β Targets Improves the Cognitive Impairment of APP/PS1/Tau Triple-Transgenic Mouse Models of Alzheimer’s Disease
Correction: Multi-Target Inhibitor of ZJQ- 3 F Against AChE/BACE1/GSK3β Targets Improves the Cognitive Impairment of APP/PS1/Tau Triple-Transgenic Mouse Models of Alzheimer’s Disease
ZJQ-3F regulates synaptic dysfunction in the cortex and hippocampus of APP/PS1/Tau transgenic mice. (A) The expression of ...
Histone Deacetylase 2 in Alzheimer’s Disease: A Comprehensive Molecular Blueprint for Therapeutic Targeting
Histone Deacetylase 2 in Alzheimer’s Disease: A Comprehensive Molecular Blueprint for Therapeutic Targeting
Alzheimer’s disease (AD), which is known for causing cognitive decline and significant synaptic dysfunction, continu...
Tau Protein Disrupts Mitochondrial Homeostasis in a Yeast Model: Implications for Alzheimer’s Disease
Tau Protein Disrupts Mitochondrial Homeostasis in a Yeast Model: Implications for Alzheimer’s Disease
The microtubule-associated protein tau plays a central role in neurodegenerative diseases, called tauopathies, but the mec...
Interruption of the Gut Integrity Contributes to Early Accumulation of Amyloid-β in the Enteric Nervous System in Rats Supplemented with a High-Fat Diet
Interruption of the Gut Integrity Contributes to Early Accumulation of Amyloid-β in the Enteric Nervous System in Rats Supplemented with a High-Fat Diet
Consumption of a high-fat diet (HFD) contributes to numerous chronic illnesses, including neurological disorders and gastr...
Boosting Brain Clean-Up: Can Targeting UPS Genes Offer Neuroprotection?
Boosting Brain Clean-Up: Can Targeting UPS Genes Offer Neuroprotection?
The ubiquitin–proteasome system (UPS) plays a critical role in protein homeostasis within eukaryotic cells. This rev...
Mendelian Randomization in Conjunction with WGCNA Was Employed to Investigate the Potential Role of the Liver-Brain Axis in the Pathogenesis of Hepatocellular Carcinoma and Alzheimer’s Disease
Mendelian Randomization in Conjunction with WGCNA Was Employed to Investigate the Potential Role of the Liver-Brain Axis in the Pathogenesis of Hepatocellular Carcinoma and Alzheimer’s Disease
Alzheimer’s disease (AD) and hepatocellular carcinoma (HCC) are prevalent age-related diseases. While the gut-liver-...
Exosomal miR-494 from Bone Marrow Mesenchymal Stem Cells Attenuates Ferroptosis and Enhances Spinal Cord Injury Repair by Modulating the SIRT1/HO-1 Pathway
Exosomal miR-494 from Bone Marrow Mesenchymal Stem Cells Attenuates Ferroptosis and Enhances Spinal Cord Injury Repair by Modulating the SIRT1/HO-1 Pathway
Spinal cord injury (SCI) is a severe traumatic disorder of the central nervous system, often resulting in partial or compl...
Evaluating the Neuroprotective and Acetylcholinesterase Inhibitory Properties of Four Calcineurin Inhibitor Drugs: Tacrolimus, Pimecrolimus, Cyclosporin A, and Voclosporin
Evaluating the Neuroprotective and Acetylcholinesterase Inhibitory Properties of Four Calcineurin Inhibitor Drugs: Tacrolimus, Pimecrolimus, Cyclosporin A, and Voclosporin
Neurodegenerative diseases (ND), marked by progressive neuronal degeneration, often involve dysregulation of acetylcholine...
Cholesterol and 24S-OHC Induce Neuronal Apoptosis and Necroptosis, but Not Ferroptosis Despite Elevated Iron Levels
Cholesterol and 24S-OHC Induce Neuronal Apoptosis and Necroptosis, but Not Ferroptosis Despite Elevated Iron Levels
Selective loss of dopaminergic neurons in the substantia nigra (SN) is the main pathological feature of Parkinson’s ...
Higenamine Hydrochloride Attenuates Neuroinflammation in Type I Diabetic Mice by Inhibiting the CRTC2-CREB Signaling Pathway via PAK4
Higenamine Hydrochloride Attenuates Neuroinflammation in Type I Diabetic Mice by Inhibiting the CRTC2-CREB Signaling Pathway via PAK4
Neuropathy is a common chronic complication of type 1 diabetes mellitus (T1D), an autoimmune disease in which neuroinflamm...
17β-Trenbolone Exposure Enhances Muscle Activity and Exacerbates Parkinson’s Disease Progression in Male Mice
17β-Trenbolone Exposure Enhances Muscle Activity and Exacerbates Parkinson’s Disease Progression in Male Mice
Parkinson’s disease (PD) ranks as the second most prevalent neurodegenerative disorder, and while the neuroprotectiv...
The Use of Identified Hypoxia-related Genes to Generate Models for Predicting the Prognosis of Cerebral Ischemia‒reperfusion Injury and Developing Treatment Strategies
The Use of Identified Hypoxia-related Genes to Generate Models for Predicting the Prognosis of Cerebral Ischemia‒reperfusion Injury and Developing Treatment Strategies
Cerebral ischemia‒reperfusion injury (CIRI) is a type of secondary brain damage caused by reperfusion after ischemic...
SRF Facilitates Transcriptional Inhibition of Gem Expression by m6A Methyltransferase METTL3 to Suppress Neuronal Damage in Epilepsy
SRF Facilitates Transcriptional Inhibition of Gem Expression by m6A Methyltransferase METTL3 to Suppress Neuronal Damage in Epilepsy
A bioinformatics analysis was conducted to screen for relevant expression datasets of the transcription factor SRF knockou...
Raloxifene Prevents Chemically-Induced Ferroptotic Neuronal Death In Vitro and In Vivo
Raloxifene Prevents Chemically-Induced Ferroptotic Neuronal Death In Vitro and In Vivo
Ferroptosis, a regulated form of cell death characterized by excessive iron-dependent lipid peroxidation, can be readily i...
Role of Exercise on Neuropathic Pain in Preclinical Models: Perspectives for Neuroglia
Role of Exercise on Neuropathic Pain in Preclinical Models: Perspectives for Neuroglia
The benefits of exercise on neuropathic pain (NP) have been demonstrated in numerous studies. In recent studies, inflammat...
The Multifaceted Role of L-Type Amino Acid Transporter 1 at the Blood–Brain Barrier: Structural Implications and Therapeutic Potential
The Multifaceted Role of L-Type Amino Acid Transporter 1 at the Blood–Brain Barrier: Structural Implications and Therapeutic Potential
L-type amino acid transporter 1 (LAT1) is integral to the transport of large neutral amino acids across the blood–br...
Antioxidant Effect of Naringin Demonstrated Through a Bayes’ Theorem Driven Multidisciplinary Approach Reveals its Prophylactic Potential as a Dietary Supplement for Ischemic Stroke
Antioxidant Effect of Naringin Demonstrated Through a Bayes’ Theorem Driven Multidisciplinary Approach Reveals its Prophylactic Potential as a Dietary Supplement for Ischemic Stroke
Naringin (NAR), a flavanone glycoside, occurs widely in citrus fruits, vegetables, and alcoholic beverages. Despite eviden...
Protective Effect of Sulfur-Containing Heterocyclic Analogs Against Acrylamide-Induced Behavioral and Biochemical Alterations in Zebrafish
Protective Effect of Sulfur-Containing Heterocyclic Analogs Against Acrylamide-Induced Behavioral and Biochemical Alterations in Zebrafish
Acrylamide (ACR) is a water-soluble monomer with broad consumer applications, even in foods due to thermal processes. Acut...
Untargeted Metabolomics Revealed that Quercetin Inhibited Ferroptosis by Improving Metabolic Disorder in the Hippocampus of Perimenopausal Depression Model Rats
Untargeted Metabolomics Revealed that Quercetin Inhibited Ferroptosis by Improving Metabolic Disorder in the Hippocampus of Perimenopausal Depression Model Rats
Perimenopausal depression is often accompanied by metabolic disorders, which have long-term harmful effects on women’...
Codon Usage Bias: A Potential Factor Affecting VGLUT Developmental Expression and Protein Evolution
Codon Usage Bias: A Potential Factor Affecting VGLUT Developmental Expression and Protein Evolution
More and more attention has been paid to the role of synonymous substitution in evolution, in which codon usage preference...
Liquid Biopsy in Neuropsychiatric Disorders: A Step Closer to Precision Medicine
Liquid Biopsy in Neuropsychiatric Disorders: A Step Closer to Precision Medicine
Psychiatric disorders are among the leading causes of disease burden worldwide. Despite their significant impact, their di...
The Aging Immune System: A Critical Attack on Ischemic Stroke
The Aging Immune System: A Critical Attack on Ischemic Stroke
Ischemic stroke caused by cerebrovascular embolism is an age-related disease with high rates of disability and mortality. ...
Allocryptopine Attenuates Inflammatory Responses in Microglial Cells Via TLR4-Dependent NF-κB and p38 MAPK Pathways
Allocryptopine Attenuates Inflammatory Responses in Microglial Cells Via TLR4-Dependent NF-κB and p38 MAPK Pathways
Studies in the existing literature propose that allocryptopine possesses both antioxidant and anti-inflammatory properties...
Mild Blast Exposure Dysregulates Metabolic Pathways and Correlation Networking as Evident from LC–MS-Based Plasma Profiling
Mild Blast Exposure Dysregulates Metabolic Pathways and Correlation Networking as Evident from LC–MS-Based Plasma Profiling
Blast-induced trauma is emerging as a serious threat due to its wide pathophysiology where not only the brain but also a s...
Identification of Potential Causal Genes for Neurodegenerative Diseases by Mitochondria-Related Genome-Wide Mendelian Randomization
Identification of Potential Causal Genes for Neurodegenerative Diseases by Mitochondria-Related Genome-Wide Mendelian Randomization
Current research lacks comprehensive investigations into the potential causal link between mitochondrial-related genes and...
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