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Gut Microbiota and Mitochondrial Dysfunction in Autism: Clinical Correlations and Future Directions
Gut Microbiota and Mitochondrial Dysfunction in Autism: Clinical Correlations and Future Directions
Autism spectrum disorder (ASD) is a multifactorial, neuro-psychiatric, and neurodevelopmental illness possessing impaired ...
Exploring Green-Synthesized Silver Nanoparticles in Neurodegeneration: a Systematic Review of Cholinesterase Enzyme Interactions
Exploring Green-Synthesized Silver Nanoparticles in Neurodegeneration: a Systematic Review of Cholinesterase Enzyme Interactions
Neurodegenerative disorders, particularly Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington&#...
Redox Perturbation in Cadmium-Mediated Hypothalamic, Pituitary, and Testicular Impairment and Protective Effects of Zinc in Rats Is Accompanied by Modulation of Tryptophan Catabolism Enzyme/Protein
Redox Perturbation in Cadmium-Mediated Hypothalamic, Pituitary, and Testicular Impairment and Protective Effects of Zinc in Rats Is Accompanied by Modulation of Tryptophan Catabolism Enzyme/Protein
Cadmium (Cd) is a toxic heavy metal found in the environment from natural (volcanic eruptions) and industrial sources, inc...
Plumbagin Ameliorate 5-Fluorouracil-Induced Cognitive Impairment in Adult Zebrafish: and Evidences
Plumbagin Ameliorate 5-Fluorouracil-Induced Cognitive Impairment in Adult Zebrafish: and Evidences
Chemotherapy is a crucial part of cancer treatment, but it has been linked to a set of cognitive impairments. 5-Fluorourac...
Lipid Metabolic Mediators Bridge Ischemic Heart Disease and Amyotrophic Lateral Sclerosis
Lipid Metabolic Mediators Bridge Ischemic Heart Disease and Amyotrophic Lateral Sclerosis
While epidemiological studies have linked cardiovascular disease (CVD) and amyotrophic lateral sclerosis (ALS), the causal...
Exploratory RNA Sequencing Reveals Systemic Metabolic Dysregulation in Alzheimer’s Disease: Insights from a Diverse Latin American Cohort
Exploratory RNA Sequencing Reveals Systemic Metabolic Dysregulation in Alzheimer’s Disease: Insights from a Diverse Latin American Cohort
Alzheimer’s disease (AD) is characterized by an insidious onset and complex pathophysiology, necessitating the devel...
Mechanistic Investigation of TSPO-Mediated Dysregulation of Mitochondrial Copper Homeostasis in Microglia and its Role in Perioperative Neurocognitive Disorders
Mechanistic Investigation of TSPO-Mediated Dysregulation of Mitochondrial Copper Homeostasis in Microglia and its Role in Perioperative Neurocognitive Disorders
Perioperative neurocognitive disorders (PND) are common complications in elderly surgical patients; their mechanisms remai...
Spatial Changes in Hippocampal Transcriptomic Profiles Following Limbic Non-convulsive Status Epilepticus: Insights into Long-Term Inflammation and Cognitive Deficits
Spatial Changes in Hippocampal Transcriptomic Profiles Following Limbic Non-convulsive Status Epilepticus: Insights into Long-Term Inflammation and Cognitive Deficits
The long-term effects of non-convulsive status epilepticus (NCSE) and their mechanisms in the brain remain largely unknown...
In Vitro Analysis of TWEAK/Fn14 Axis in the Blood–Brain Barrier Models during Oxygen–Glucose Deprivation and Reoxygenation
In Vitro Analysis of TWEAK/Fn14 Axis in the Blood–Brain Barrier Models during Oxygen–Glucose Deprivation and Reoxygenation
Upregulation of tumor necrosis factor-like weak apoptosis-inducing factor (TWEAK) and its receptor fibroblast growth facto...
Gastrodin Ameliorates Pain-Depression Comorbidity through SIRT3-Dependent Alleviation of Oxidative Stress and Promotion of Mitochondrial Biogenesis
Gastrodin Ameliorates Pain-Depression Comorbidity through SIRT3-Dependent Alleviation of Oxidative Stress and Promotion of Mitochondrial Biogenesis
Neuropathic pain (NP) and depression frequently co-occur, creating a complex clinical challenge with limited therapeutic o...
P2X7 Receptor Inhibition Mitigates Microglial Activation, Neuroinflammation, and Secondary Thalamic Damage After Ischemic Stroke
P2X7 Receptor Inhibition Mitigates Microglial Activation, Neuroinflammation, and Secondary Thalamic Damage After Ischemic Stroke
Secondary damage in remote brain regions following ischemic stroke significantly worsens patient outcomes, yet its underly...
Serum miRNA-155 and TREM2 as Non-Invasive Biomarkers for Monitoring Neuroinflammation and Disease Activity in Multiple Sclerosis
Serum miRNA-155 and TREM2 as Non-Invasive Biomarkers for Monitoring Neuroinflammation and Disease Activity in Multiple Sclerosis
Serum miRNA-155 and TREM2 levels were investigated as potential non-invasive indicators. In this case–control study,...
Synergistic Efficacy of Supernatant-Preconditioned BM-MSCs in Alleviating Depression, Anxiety-Like Behavior, and Memory Impairment in a Rat Stress Model by Suppressing the NF-κB Pathway
Synergistic Efficacy of Supernatant-Preconditioned BM-MSCs in Alleviating Depression, Anxiety-Like Behavior, and Memory Impairment in a Rat Stress Model by Suppressing the NF-κB Pathway
Mesenchymal stem cells (MSCs)–based therapy has received considerable research attention for its anti-inflammatory p...
Offers Vagus-Dependent Neuroprotection Against Parkinson’s Disease
Offers Vagus-Dependent Neuroprotection Against Parkinson’s Disease
Parkinson’s disease (PD) is characterized by dopaminergic neurodegeneration and increasingly associated with gut mic...
Up-regulated miR-4443 Holds Diagnostic Significance for Parkinson’s Disease and may be Involved in Neuroinflammation
Up-regulated miR-4443 Holds Diagnostic Significance for Parkinson’s Disease and may be Involved in Neuroinflammation
Parkinson’s disease (PD) is a widespread neurodegenerative disorder. MicroRNAs (miRNAs) have emerged as crucial regu...
VKORC1L1 Downregulation Induced Vitamin K Cycle Disorder Exacerbates Neuronal Ferroptosis After Spinal Cord Injury
VKORC1L1 Downregulation Induced Vitamin K Cycle Disorder Exacerbates Neuronal Ferroptosis After Spinal Cord Injury
Ferroptosis contributes significantly to neuronal loss and functional decline after spinal cord injury (SCI). Emerging evi...
Endoplasmic Reticulum Stress in Spinal Cord Injury: Pathological Roles, Molecular Targets, and Emerging Treatments: A Systematic Review
Endoplasmic Reticulum Stress in Spinal Cord Injury: Pathological Roles, Molecular Targets, and Emerging Treatments: A Systematic Review
Spinal cord injuries (SCI) are associated with significant physical and economic burdens on individuals and healthcare sys...
4E-BP2-dependent translational control in GABAergic interneurons is required for long-term memory
4E-BP2-dependent translational control in GABAergic interneurons is required for long-term memory
mRNA translational repression by eukaryotic initiation factor 4E-binding proteins (4E-BPs), plays a critical role in synap...
Ptbp2 Alleviates Neuroinflammation and Blood–brain Barrier Disruption via Modulating Microglial Polarization in Ischemic Stroke
Ptbp2 Alleviates Neuroinflammation and Blood–brain Barrier Disruption via Modulating Microglial Polarization in Ischemic Stroke
Damage following ischemic stroke is worsened by microglial activation and subsequent neuroinflammation. Polypyrimidine tra...
Gulf War Illness: Neurological Impacts, Pathophysiological Insights, and Therapeutic Prospects
Gulf War Illness: Neurological Impacts, Pathophysiological Insights, and Therapeutic Prospects
Gulf War Illness (GWI) is a chronic, multi-system condition affecting a substantial proportion of veterans deployed during...
Brain-Derived Exosomes in Neurodevelopmental and Neuropsychiatric Disorders: Molecular Insights, Therapeutic Potential, and Translational Challenges
Brain-Derived Exosomes in Neurodevelopmental and Neuropsychiatric Disorders: Molecular Insights, Therapeutic Potential, and Translational Challenges
Neurodevelopmental disorders (NDDs), including autism spectrum disorders, attention-deficit hyperactivity disorders, schiz...
DDX3X Aggravates Neuronal Pyroptosis and Inhibits Autophagy via NLRP3 Inflammasome After Experimental Subarachnoid Hemorrhage
DDX3X Aggravates Neuronal Pyroptosis and Inhibits Autophagy via NLRP3 Inflammasome After Experimental Subarachnoid Hemorrhage
Neuronal cell death is considered the symbol of early brain injury after subarachnoid hemorrhage (SAH), but the mechanism ...
An Exploratory Analysis of Differential Tear Fluid miRNAs in Patients with Parkinson’s Disease and Atypical Parkinsonian Syndromes
An Exploratory Analysis of Differential Tear Fluid miRNAs in Patients with Parkinson’s Disease and Atypical Parkinsonian Syndromes
Parkinson’s disease (PD), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP) are neurodegenerat...
Downregulation of Glycogen Synthase Kinase-3 Beta by L. Contributes to Neuroprotection Against Aluminum Chloride-Mediated Neurotoxicity in Zebrafish Larvae
Downregulation of Glycogen Synthase Kinase-3 Beta by L. Contributes to Neuroprotection Against Aluminum Chloride-Mediated Neurotoxicity in Zebrafish Larvae
Urtica dioica L. (U. dioica; Family Urticaceae) has been utilized since ancient times, both as a nutritional source and fo...
s KM71H Attenuates Cognitive Deficits and Depressive-Like Behavior by the TLR4/NF-κB Signaling Pathway in an Aβ-Induced AD-Like Mouse Model
s KM71H Attenuates Cognitive Deficits and Depressive-Like Behavior by the TLR4/NF-κB Signaling Pathway in an Aβ-Induced AD-Like Mouse Model
Komagataella pastoris is a promising probiotic for modulating the microbiota-gut-brain axis, and growing evidence has demo...
Correction: Multi-Target Inhibitor of ZJQ- 3 F Against AChE/BACE1/GSK3β Targets Improves the Cognitive Impairment of APP/PS1/Tau Triple-Transgenic Mouse Models of Alzheimer’s Disease
Correction: Multi-Target Inhibitor of ZJQ- 3 F Against AChE/BACE1/GSK3β Targets Improves the Cognitive Impairment of APP/PS1/Tau Triple-Transgenic Mouse Models of Alzheimer’s Disease
ZJQ-3F regulates synaptic dysfunction in the cortex and hippocampus of APP/PS1/Tau transgenic mice. (A) The expression of ...
Histone Deacetylase 2 in Alzheimer’s Disease: A Comprehensive Molecular Blueprint for Therapeutic Targeting
Histone Deacetylase 2 in Alzheimer’s Disease: A Comprehensive Molecular Blueprint for Therapeutic Targeting
Alzheimer’s disease (AD), which is known for causing cognitive decline and significant synaptic dysfunction, continu...
Tau Protein Disrupts Mitochondrial Homeostasis in a Yeast Model: Implications for Alzheimer’s Disease
Tau Protein Disrupts Mitochondrial Homeostasis in a Yeast Model: Implications for Alzheimer’s Disease
The microtubule-associated protein tau plays a central role in neurodegenerative diseases, called tauopathies, but the mec...
Interruption of the Gut Integrity Contributes to Early Accumulation of Amyloid-β in the Enteric Nervous System in Rats Supplemented with a High-Fat Diet
Interruption of the Gut Integrity Contributes to Early Accumulation of Amyloid-β in the Enteric Nervous System in Rats Supplemented with a High-Fat Diet
Consumption of a high-fat diet (HFD) contributes to numerous chronic illnesses, including neurological disorders and gastr...
Boosting Brain Clean-Up: Can Targeting UPS Genes Offer Neuroprotection?
Boosting Brain Clean-Up: Can Targeting UPS Genes Offer Neuroprotection?
The ubiquitin–proteasome system (UPS) plays a critical role in protein homeostasis within eukaryotic cells. This rev...
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