Rehm J, Shield KD (2019) Global burden of disease and the impact of mental and addictive disorders. Curr Psychiatry Rep 21:10. https://doi.org/10.1007/s11920-019-0997-0

Article  PubMed  Google Scholar 

World Health Organization (2013) Mental health action plan 2013–2020. World Health Organization, Geneva

Google Scholar 

Arias D, Saxena S, Verguet S (2022) Quantifying the global burden of mental disorders and their economic value. eClinicalMedicine 54. https://doi.org/10.1016/j.eclinm.2022.101675

García-Gutiérrez MS, Navarrete F, Sala F, Gasparyan A, Austrich-Olivares A, Manzanares J (2020) Biomarkers in psychiatry: concept, definition, types and relevance to the clinical reality. Front Psychiatry 11. https://doi.org/10.3389/fpsyt.2020.00432

Bardelli A, Pantel K (2017) Liquid biopsies, what we do not know (yet). Cancer Cell 31:172–179. https://doi.org/10.1016/j.ccell.2017.01.002

Article  CAS  PubMed  Google Scholar 

Lo YMD, Han DSC, Jiang P, Chiu RWK (2021) Epigenetics, fragmentomics, and topology of cell-free DNA in liquid biopsies. Science 372:eaaw3616. https://doi.org/10.1126/science.aaw3616

Marrugo-Ramírez J, Mir M, Samitier J (2018) Blood-based cancer biomarkers in liquid biopsy: a promising non-invasive alternative to tissue biopsy. Int J Mol Sci 19:2877. https://doi.org/10.3390/ijms19102877

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alix-Panabières C, Schwarzenbach H, Pantel K (2012) Circulating tumor cells and circulating tumor DNA. Annu Rev Med 63:199–215. https://doi.org/10.1146/annurev-med-062310-094219

Article  CAS  PubMed  Google Scholar 

Joosse SA, Pantel K (2015) Tumor-educated platelets as liquid biopsy in cancer patients. Cancer Cell 28:552–554. https://doi.org/10.1016/j.ccell.2015.10.007

Article  CAS  PubMed  Google Scholar 

Meng S, Tripathy D, Frenkel EP, Shete S, Naftalis EZ, Huth JF, Beitsch PD, Leitch M et al (2004) Circulating tumor cells in patients with breast cancer dormancy. Clin Cancer Res Off J Am Assoc Cancer Res 10:8152–8162. https://doi.org/10.1158/1078-0432.CCR-04-1110

Article  Google Scholar 

Chen L, Bode AM, Dong Z (2017) Circulating tumor cells: moving biological insights into detection. Theranostics 7:2606–2619. https://doi.org/10.7150/thno.18588

Article  CAS  PubMed  PubMed Central  Google Scholar 

Visal TH, den Hollander P, Cristofanilli M, Mani SA (2022) Circulating tumour cells in the -omics era: how far are we from achieving the ‘singularity’? Br J Cancer 127:173–184. https://doi.org/10.1038/s41416-022-01768-9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Meikle CKS, Kelly CA, Garg P, Wuescher LM, Ali RA, Worth RG (2017) Cancer and thrombosis: the platelet perspective. Front Cell Dev Biol 4. https://doi.org/10.3389/fcell.2016.00147

Roweth HG, Battinelli EM (2021) Lessons to learn from tumor-educated platelets. Blood 137:3174–3180. https://doi.org/10.1182/blood.2019003976

Article  CAS  PubMed  PubMed Central  Google Scholar 

Best MG, Sol N, Kooi I, Tannous J, Westerman BA, Rustenburg F, Schellen P, Verschueren H et al (2015) RNA-Seq of tumor-educated platelets enables blood-based pan-cancer, multiclass, and molecular pathway cancer diagnostics. Cancer Cell 28:666–676. https://doi.org/10.1016/j.ccell.2015.09.018

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu C, Zhao J, Tian F, Cai L, Zhang W, Feng Q, Chang J, Wan F et al (2019) Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers. Nat Biomed Eng 3:183–193. https://doi.org/10.1038/s41551-018-0343-6

Article  CAS  PubMed  Google Scholar 

Shurtleff MJ, Temoche-Diaz MM, Schekman R (2018) Extracellular vesicles and cancer: caveat lector. Annu Rev Cancer Biol 2:395–411. https://doi.org/10.1146/annurev-cancerbio-030617-050519

Article  Google Scholar 

Doyle LM, Wang MZ (2019) Overview of extracellular vesicles, their origin, composition, purpose, and methods for exosome isolation and analysis. Cells 8:727. https://doi.org/10.3390/cells8070727

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liang Y, Lehrich BM, Zheng S, Lu M (2021) Emerging methods in biomarker identification for extracellular vesicle-based liquid biopsy. J Extracell Vesicles 10:e12090. https://doi.org/10.1002/jev2.12090

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grabuschnig S, Bronkhorst AJ, Holdenrieder S, Rosales Rodriguez I, Schliep KP, Schwendenwein D, Ungerer V, Sensen CW (2020) Putative origins of cell-free DNA in humans: a review of active and passive nucleic acid release mechanisms. Int J Mol Sci 21:8062. https://doi.org/10.3390/ijms21218062

Article  CAS  PubMed  PubMed Central  Google Scholar 

Szilágyi M, Pös O, Márton É, Buglyó G, Soltész B, Keserű J, Penyige A, Szemes T et al (2020) Circulating cell-free nucleic acids: main characteristics and clinical application. Int J Mol Sci 21:6827. https://doi.org/10.3390/ijms21186827

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mandel P, Metais P (1948) Les acides nucléiques du plasma sanguin chez l’Homme. C R Seances Soc Biol Fil 142:241–243

CAS  PubMed  Google Scholar 

Tan EM, Schur PH, Carr RI, Kunkel HG (1966) Deoxybonucleic acid (DNA) and antibodies to DNA in the serum of patients with systemic lupus erythematosus. J Clin Invest 45:1732. https://doi.org/10.1172/JCI105479

Article  CAS  PubMed  PubMed Central  Google Scholar 

Leon SA, Shapiro B, Sklaroff DM, Yaros MJ (1977) Free DNA in the serum of cancer patients and the effect of therapy. Cancer Res 37:646–650

CAS  PubMed  Google Scholar 

Stroun M, Anker P, Maurice P, Lyautey J, Lederrey C, Beljanski M (1989) Neoplastic characteristics of the DNA found in the plasma of cancer patients. Oncology 46:318–322. https://doi.org/10.1159/000226740

Article  CAS  PubMed  Google Scholar 

Vasioukhin V, Anker P, Maurice P, Lyautey J, Lederrey C, Stroun M (1994) Point mutations of the N-ras gene in the blood plasma DNA of patients with myelodysplastic syndrome or acute myelogenous leukaemia. Br J Haematol 86:774–779. https://doi.org/10.1111/j.1365-2141.1994.tb04828.x

Article  CAS  PubMed  Google Scholar 

Sorenson GD, Pribish DM, Valone FH, Memoli VA, Bzik DJ, Yao SL (1994) Soluble normal and mutated DNA sequences from single-copy genes in human blood. Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Cosponsored Am Soc Prev Oncol 3:67–71

CAS  Google Scholar 

Bryzgunova OE, Konoshenko MY, Laktionov PP (2021) Concentration of cell-free DNA in different tumor types. Expert Rev Mol Diagn 21:63–75. https://doi.org/10.1080/14737159.2020.1860021

Article  CAS  PubMed  Google Scholar 

Andreatta MV, Curty VM, Coutinho JVS, Santos MÂA, Vassallo PF, de Sousa NF, Barauna VG (2018) Cell-free DNA as an earlier predictor of exercise-induced performance decrement related to muscle damage. Int J Sports Physiol Perform 13:953–956. https://doi.org/10.1123/ijspp.2017-0421

Article  PubMed  Google Scholar 

Lo YMD, Tein MSC, Lau TK, Haines CJ, Leung TN, Poon PMK, Wainscoat JS, Johnson PJ et al (1998) Quantitative analysis of fetal DNA in maternal plasma and serum: implications for noninvasive prenatal diagnosis. Am J Hum Genet 62:768–775. https://doi.org/10.1086/301800

Article  CAS  PubMed  PubMed Central  Google Scholar 

Meddeb R, Dache ZAA, Thezenas S, Otandault A, Tanos R, Pastor B, Sanchez C, Azzi J et al (2019) Quantifying circulating cell-free DNA in humans. Sci Rep 9:5220. https://doi.org/10.1038/s41598-019-41593-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rainer TH, Wong LKS, Lam W, Yuen E, Lam NYL, Metreweli C, Lo YMD (2003) Prognostic use of circulating plasma nucleic acid concentrations in patients with acute stroke. Clin Chem 49:562–569. https://doi.org/10.1373/49.4.562

Article