Antioxidant Effect of Naringin Demonstrated Through a Bayes’ Theorem Driven Multidisciplinary Approach Reveals its Prophylactic Potential as a Dietary Supplement for Ischemic Stroke

Howes MR, Perry NSL, Vásquez-Londoño C, Perry EK (2020) Role of phytochemicals as nutraceuticals for cognitive functions affected in ageing. Br J Pharmacol 177(6):1294–1315. https://doi.org/10.1111/bph.14898

Article  CAS  PubMed  PubMed Central  Google Scholar 

Neveu V, Perez-Jiménez J, Vos F, Crespy V, du Chaffaut L, Mennen L, Knox C, Eisner R et al (2010) Phenol-Explorer: an online comprehensive database on polyphenol contents in foods. Database (Oxford) 2010:bap024. https://doi.org/10.1093/database/bap024

Article  CAS  PubMed  Google Scholar 

Liguori I, Russo G, Curcio F, Bulli G, Aran L, Della-Morte D, Gargiulo G, Testa G, Cacciatore F, Bonaduce D, Abete P (2018) Oxidative stress, aging, and diseases. Clin Interv Aging 13:757–772. https://doi.org/10.2147/CIA.S158513

Article  CAS  PubMed  PubMed Central  Google Scholar 

Edaravone Acute Infarction Study G (2003) Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters. Cerebrovasc Dis 15 (3):222–229. https://doi.org/10.1159/000069318

Writing G, Edaravone ALSSG (2017) Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial. Lancet Neurol 16(7):505–512. https://doi.org/10.1016/S1474-4422(17)30115-1

Article  Google Scholar 

Okuyama S, Yamamoto K, Mori H, Sawamoto A, Amakura Y, Yoshimura M, Tamanaha A, Ohkubo Y et al (2018) Neuroprotective effect of Citrus kawachiensis (Kawachi Bankan) peels, a rich source of naringin, against global cerebral ischemia/reperfusion injury in mice. Biosci Biotechnol Biochem 82(7):1216–1224. https://doi.org/10.1080/09168451.2018.1456320

Article  CAS  PubMed  Google Scholar 

Feng J, Chen X, Lu S, Li W, Yang D, Su W, Wang X, Shen J (2018) Naringin attenuates cerebral ischemia-reperfusion injury through inhibiting peroxynitrite-mediated mitophagy activation. Mol Neurobiol 55(12):9029–9042. https://doi.org/10.1007/s12035-018-1027-7

Article  CAS  PubMed  Google Scholar 

Yang J, Yuan L, Wen Y, Zhou H, Jiang W, Xu D, Wang M (2020) Protective effects of naringin in cerebral infarction and its molecular mechanism. Med Sci Monit 26:e918772. https://doi.org/10.12659/msm.918772

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cao W, Feng SJ, Kan MC (2021) Naringin targets NFKB1 to alleviate oxygen-glucose deprivation/reoxygenation-induced injury in PC12 cells via modulating HIF-1alpha/AKT/mTOR-signaling pathway. J Mol Neurosci 71(1):101–111. https://doi.org/10.1007/s12031-020-01630-8

Article  CAS  PubMed  Google Scholar 

Han Y, Su J, Liu X, Zhao Y, Wang C, Li X (2017) Naringin alleviates early brain injury after experimental subarachnoid hemorrhage by reducing oxidative stress and inhibiting apoptosis. Brain Res Bull 133:42–50. https://doi.org/10.1016/j.brainresbull.2016.12.008

Article  CAS  PubMed  Google Scholar 

Gaur V, Aggarwal A, Kumar A (2009) Protective effect of naringin against ischemic reperfusion cerebral injury: possible neurobehavioral, biochemical and cellular alterations in rat brain. Eur J Pharmacol 616(1–3):147–154. https://doi.org/10.1016/j.ejphar.2009.06.056

Article  CAS  PubMed  Google Scholar 

Collaborators GBDS (2021) Global, regional, and national burden of stroke and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurol 20(10):795–820. https://doi.org/10.1016/S1474-4422(21)00252-0

Article  Google Scholar 

Granato D, Barba FJ, Bursać Kovačević D, Lorenzo JM, Cruz AG, Putnik P (2020) Functional foods: product development, technological trends, efficacy testing, and safety. Annu Rev Food Sci Technol 11:93–118. https://doi.org/10.1146/annurev-food-032519-051708

Article  CAS  PubMed  Google Scholar 

Skariah G, Seimetz J, Norsworthy M, Lannom MC, Kenny PJ, Elrakhawy M, Forsthoefel C, Drnevich J et al (2017) Mov10 suppresses retroelements and regulates neuronal development and function in the developing brain. BMC Biol 15(1):54. https://doi.org/10.1186/s12915-017-0387-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Perez-Riverol Y, Csordas A, Bai J, Bernal-Llinares M, Hewapathirana S, Kundu DJ, Inuganti A, Griss J et al (2019) The PRIDE database and related tools and resources in 2019: improving support for quantification data. Nucleic Acids Res 47(D1):D442–D450. https://doi.org/10.1093/nar/gky1106

Article  CAS  PubMed  Google Scholar 

Hornburg D, Drepper C, Butter F, Meissner F, Sendtner M, Mann M (2014) Deep proteomic evaluation of primary and cell line motoneuron disease models delineates major differences in neuronal characteristics. Mol Cell Proteomics 13(12):3410–3420. https://doi.org/10.1074/mcp.M113.037291

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cox D, Ang CS, Nillegoda NB, Reid GE, Hatters DM (2022) Hidden information on protein function in censuses of proteome foldedness. Nat Commun 13(1):1992. https://doi.org/10.1038/s41467-022-29661-2

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen LL, Wang YB, Song JX, Deng WK, Lu JH, Ma LL, Yang CB, Li M et al (2017) Phosphoproteome-based kinase activity profiling reveals the critical role of MAP2K2 and PLK1 in neuronal autophagy. Autophagy 13(11):1969–1980. https://doi.org/10.1080/15548627.2017.1371393

Article  CAS  PubMed  PubMed Central  Google Scholar 

Branca RM, Orre LM, Johansson HJ, Granholm V, Huss M, Perez-Bercoff A, Forshed J, Kall L et al (2014) HiRIEF LC-MS enables deep proteome coverage and unbiased proteogenomics. Nat Methods 11(1):59–62. https://doi.org/10.1038/nmeth.2732

Article  CAS  PubMed  Google Scholar 

Zhou Y, Gao J, Zhu H, Xu J, He H, Gu L, Wang H, Chen J et al (2018) Enhancing membrane protein identification using a simplified centrifugation and detergent-based membrane extraction approach. Anal Chem 90(4):2434–2439. https://doi.org/10.1021/acs.analchem.7b03710

Article  CAS  PubMed  Google Scholar 

Babu M, Singh N, Datta A (2022) In vitro oxygen glucose deprivation model of ischemic stroke: a proteomics-driven systems biological perspective. Mol Neurobiol 59(4):2363–2377. https://doi.org/10.1007/s12035-022-02745-2

Article  CAS  PubMed  Google Scholar 

Medvar B, Raghuram V, Pisitkun T, Sarkar A, Knepper MA (2016) Comprehensive database of human E3 ubiquitin ligases: application to aquaporin-2 regulation. Physiol Genomics 48(7):502–512. https://doi.org/10.1152/physiolgenomics.00031.2016

Article  CAS  PubMed  PubMed Central  Google Scholar 

Leo KT, Chou CL, Yang CR, Park E, Raghuram V, Knepper MA (2022) Bayesian analysis of dynamic phosphoproteomic data identifies protein kinases mediating GPCR responses. Cell Commun Signal 20(1):80. https://doi.org/10.1186/s12964-022-00892-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Datta A, Park JE, Li X, Zhang H, Ho ZS, Heese K, Lim SK, Tam JP et al (2010) Phenotyping of an in vitro model of ischemic penumbra by iTRAQ-based shotgun quantitative proteomics. J Proteome Res 9(1):472–484. https://doi.org/10.1021/pr900829h

Article  CAS  PubMed  Google Scholar 

Mohamed EA, Abu H II, Yusif RM, Shaaban AAA, El-Sheakh AR, Hamed MF, Badria FAE (2018) Polymeric micelles for potentiated antiulcer and anticancer activities of naringin. Int J Nanomedicine 13:1009–1027. https://doi.org/10.2147/ijn.S154325

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eruslanov E, Kusmartsev S (2010) Identification of ROS using oxidized DCFDA and flow-cytometry. Methods Mol Biol 594:57–72. https://doi.org/10.1007/978-1-60761-411-1_4

Article  CAS  PubMed  Google Scholar 

van Zundert GCP, Rodrigues J, Trellet M, Schmitz C, Kastritis PL, Karaca E, Melquiond ASJ, van Dijk M et al (2016) The HADDOCK2.2 web server: user-friendly integrative modeling of biomolecular complexes. J Mol Biol 428(4):720–725. https://doi.org/10.1016/j.jmb.2015.09.014

Article 

Comments (0)

No login
gif