Akdis M, Blaser K, Akdis CA (2005) T regulatory cells in allergy: novel concepts in the pathogenesis, prevention, and treatment of allergic diseases. J Allergy Clin Immun 116:961–968. https://doi.org/10.1016/j.jaci.2005.09.004

Article  CAS  PubMed  Google Scholar 

Amin K (2012) The role of mast cells in allergic inflammation. Resp Med 106:9–14. https://doi.org/10.1016/j.rmed.2011.09.007

Article  Google Scholar 

Chan SF, Chen YY, Lin JJ, Liao CL, Ko YC, Tang NY, Kuo CL, Liu KC, Chung JG (2017) Triptolide induced cell death through apoptosis and autophagy in murine leukemia WEHI-3 cells in vitro and promoting immune responses in WEHI-3 generated leukemia mice in vivo. Environ Toxicol 32:550–568. https://doi.org/10.1002/tox.22259

Article  CAS  PubMed  Google Scholar 

Corson TW, Crews CM (2007) Molecular understanding and Modern Application of Traditional Medicines. Triumphs Trials Cell 130:769–774. https://doi.org/10.1016/j.cell.2007.08.021

Article  CAS  PubMed  Google Scholar 

Dai W, Sun Y, Zhong G (2020) A network pharmacology approach to estimate the active ingredients and potential targets of cuscutae semen in the treatment of osteoporosis. Med Sci Monit 26:1–20. https://doi.org/10.12659/MSM.920485

Article  Google Scholar 

Elieh Ali Komi D, Wöhrl S, Bielory L (2020) Mast Cell Biology at Molecular Level: a Comprehensive Review. Clin Rev Allerg Immu 58:342–365. https://doi.org/10.1007/s12016-019-08769-2

Article  Google Scholar 

Han EH, Park JH, Kim JY, Jeong HG (2009) Houttuynia cordata water extract suppresses anaphylactic reaction and IgE-mediated allergic response by inhibiting multiple steps of FcεRI signaling in mast cells. Food Chem Toxicol 47:1659–1666. https://doi.org/10.1016/j.fct.2009.04.025

Article  CAS  PubMed  Google Scholar 

Hwang SL, Lu Y, Li X, Kim YD, Cho YS, Jahng Y, Son JK, Lee YJ, Kang WK, Taketomi Y, Murakami M, Moon TC, Chang HW (2014) ERK1/2 antagonize AMPK-dependent regulation of fc epsilon RI-mediated mast cell activation and anaphylaxis. J Allergy Clin Immun 134:714–. https://doi.org/10.1016/j.jaci.2014.05.001

Article  CAS  PubMed  Google Scholar 

Kim HH, Park SB, Lee S, Kwon TK, Shin TY, Park PH, Lee SH, Kim SH (2014) Inhibitory effect of putranjivain A on allergic inflammation through suppression of mast cell activation. Toxicol Appl Pharm 274:455–461. https://doi.org/10.1016/j.taap.2013.12.006

Article  CAS  Google Scholar 

Lopez S, Gomez E, Torres MJ, Pozo D, Fernandez TD, Ariza A, Sanz ML, Blanca M, Mayorga C (2015) Betalactam antibiotics affect human dendritic cells maturation through MAPK/NF-kB systems. Role in allergic reactions to drugs. Toxicol Appl Pharm 288:289–299. https://doi.org/10.1016/j.taap.2015.08.001

Article  CAS  Google Scholar 

Lu Y, Yang JH, Li X, Hwangbo K, Hwang SL, Taketomi Y, Murakami M, Chang YC, Kim CH, Son JK, Chang HW (2011) Emodin, a naturally occurring anthraquinone derivative, suppresses IgE-mediated anaphylactic reaction and mast cell activation. Biochem Pharmacol 82:1700–1708. https://doi.org/10.1016/j.bcp.2011.08.022

Article  CAS  PubMed  Google Scholar 

Luo TT, Lu Y, Yan SK, Xiao X, Rong XL, Guo J (2020) Network Pharmacology in Research of Chinese Medicine Formula: methodology, application and prospective. Chin J Integr Med 26:72–80. https://doi.org/10.1007/s11655-019-3064-0

Article  CAS  PubMed  Google Scholar 

Luo P, Liu D, Zhang Q (2022) Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1. Acta Pharm Sin B 12:2300–2314. https://doi.org/10.1016/j.apsb.2021.12.007

Article  CAS  PubMed  Google Scholar 

Nishida K, Yamasaki S, Ito Y, Kabu K, Hattori K, Tezuka T, Nishizumi H, Kitamura D, Goitsuka R, Geha RS, Yamamoto T, Yagi T, Hirano T (2005) FcεRI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane. J Cell Biol 170:115–126. https://doi.org/10.1083/jcb.200501111

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qu SH, Qin TJ, Li M, Zhang SJ, Ye LS, Wei JZ, Fan H, Chen BW (2018) The effects of resiquimod in an ovalbumin-induced allergic rhinitis model. Int Immunopharmacol 59:233–242. https://doi.org/10.1016/j.intimp.2018.04.015

Article  CAS  PubMed  Google Scholar 

Rivas MN, Burton OT, Oettgen HC, Chatila T (2016) IL-4 production by group 2 innate lymphoid cells promotes food allergy by blocking regulatory T-cell function. J Allergy Clin Immun 138:801. https://doi.org/10.1016/j.jaci.2016.02.030

Article  CAS  Google Scholar 

Syu BJ, Loh CE, Hsueh YH, Gershwin ME, Chuang YH (2016) Dual roles of IFN-gamma and IL-4 in the natural history of murine autoimmune cholangitis: IL-30 and implications for Precision Medicine. Sci Rep-UK 6:34884. https://doi.org/10.1038/srep34884

Article  CAS  Google Scholar 

Wang Z, Ravula R, Shi L, Song Y, Yeung S, Liu M, Lau B, Hao J, Wang J, Lam CWK, Chow MSS, Huang Y (2016) Overcoming chemoresistance in prostate cancer with Chinese medicine Tripterygium Wilfordii via multiple mechanisms. Oncotarget 7:61246–61261. https://doi.org/10.18632/oncotarget.10868

Article  PubMed  PubMed Central  Google Scholar 

Wang Y, Guo SH, Shang XJ, Yu LS, Zhu JW, Zhao A, Zhou YF, An GH, Zhang Q, Ma B (2018) Triptolide induces sertoli cell apoptosis in mice via ROS/JNK-dependent activation of the mitochondrial pathway and inhibition of Nrf2-mediated antioxidant response. Acta Pharmacol Sin 39:311–327. https://doi.org/10.1038/aps.2017.95

Article  CAS  PubMed  Google Scholar 

Wong CK, Tsang CM, Ip WK, Lam CWK (2006) Molecular mechanisms for the release of chemokines from human leukemic mast cell line (HMC)-1 cells activated by SCF and TNF-α: roles of ERK, p38 MAPK, and NF-κB. Allergy 61:289–297. https://doi.org/10.1111/j.1398-9995.2006.00972.x

Article  CAS  PubMed  Google Scholar 

Xu YJ, Li WW, Wen RJ, Sun JF, Liu X, Zhao SF, Zhang JH, Liu YF, Zhao MY (2023) Voltage-gated sodium channels, potential targets of Tripterygium Wilfordii Hook. f. to exert activity and produce toxicity. J Ethnopharmacol 311:116448. https://doi.org/10.1016/j.jep.2023.116448

Article  CAS  PubMed  Google Scholar 

Zhang X, Xia J, Jiang Y, Pisetsky DS, Smolen JS, Mu R, Dai SM, Weinblatt ME, Kvien TK, Li J, Dörner T, Zhang Y, Lu LW, Yang CD, Yang PT, Zhang Y, Xu CC, Zhao Z, Lipsky PE (2023a) International consensus guidance for the use of Tripterygium Wilfordii Hook F in the treatment of active rheumatoid arthritis. J Autoimmun 142(2024):103148. https://doi.org/10.1016/j.jaut.2023.103148

Article  PubMed  Google Scholar 

Zhang L, Jiang SQ, Guan ZH, Huang JY, Yin ZK, Tan GY, Wang YY, Zhao ZX, Huang M, Jin J (2023b) Effect of Salvia miltiorrhiza Bunge extracts on improving the efficacy and reducing the toxicity of Tripterygium Wilfordii polyglycosides in the treatment of rheumatoid arthritis. J Ethnopharmacol 317:116782. https://doi.org/10.1016/j.jep.2023.116782

Article  CAS  PubMed  Google Scholar 

Zhao H, Shan Y, Ma Z, Yu M, Gong B (2019) A network pharmacology approach to explore active compounds and pharmacological mechanisms of epimedium for treatment of premature ovarian insufficiency. Drug Des Dev Ther 13:2997–3007. https://doi.org/10.2147/DDDT.S207823

Article  CAS  Google Scholar 

Zhu GZ, Han XC, Wang HZ, Yang YZ, Gao Y, Wang HL (2019) Effect of Tripterygium glycosides tablets in treating rheumatoid arthritis:a systematic review and Meta-analysis. China J Chin Mater Med 44:3358–3364. https://doi.org/10.19540/j.cnki.cjcmm.20190305.004

Article  Google Scholar 

Ziaei S, Halaby R (2016) Immunosuppressive, anti-inflammatory and anti-cancer properties of triptolide: a mini review. Avicenna J Phytomed 6:149–164. https://doi.org/10.22038/AJP.2016.6329

Article  CAS  PubMed  PubMed Central  Google Scholar