Anti-adipogenic activity of oleoresin from seeds via modulation of PPAR-γ and C/EBP-α expression in 3T3-L1 adipocytes

Asgary S, Ghannadi A, Dashti G, Helalat A, Sahebkar A, Najafi S (2013) Nigella sativa L. improves lipid profile and prevents atherosclerosis: evidence from an experimental study on hypercholesterolemic rabbits. J Funct Foods 5(1):228–234. https://doi.org/10.1016/j.jff.2012.10.011

Article  CAS  Google Scholar 

Bashir KMI, Kim JW, Kim JK, Chun YS, Choi JS, Ku SK (2023) Efficacy confirmation test of black cumin (Nigella sativa L.) seeds extract using a high-Fat Diet Mouse Model. Metabolites 13(4). https://doi.org/10.3390/metabo13040501

Bulló M, García-Lorda P, Peinado-Onsurbe J, Hernández M, Argilés JM, Salas-Salvadó J (2002) TNFα expression of subcutaneous adipose tissue in obese and morbid obese females: relationship to adipocyte LPL activity and leptin synthesis. Int J Obes 26(5):652–658. https://doi.org/10.1038/sj.ijo.0801977

Article  Google Scholar 

Calzadilla P, Sapochnik D, Cosentino S, Diz V, Dicelio L, Calvo JC, Guerra LN (2011) N-acetylcysteine reduces markers of differentiation in 3T3-L1 adipocytes. Int J Mol Sci 12(10):6936–6951. https://doi.org/10.3390/ijms12106936

Article  CAS  PubMed  PubMed Central  Google Scholar 

Calzadilla P, Gómez-Serrano M, García-Santos E, Schiappacasse A, Abalde Y, Calvo JC, Peral B, Guerra LN (2013) N-Acetylcysteine affects obesity-related protein expression in 3T3-L1 adipocytes. Redox Rep 18(6):210–218. https://doi.org/10.1179/1351000213Y.0000000066

Article  CAS  PubMed  PubMed Central  Google Scholar 

Evans ME, Brown JM, McIntosh MK (2002) Isomer-specific effects of conjugated linoleic acid (CLA) on adiposity and lipid metabolism. J Nutr Biochem 13(9):508–516. https://doi.org/10.1016/S0955-2863(02)00211-5

Article  CAS  PubMed  Google Scholar 

Fukumitsu S, Aida K, Ueno N, Ozawa S, Takahashi Y, Kobori M (2008) Flaxseed Lignan attenuates high-fat diet-induced fat accumulation and induces adiponectin expression in mice. Br J Nutr 100(3):669–676. https://doi.org/10.1017/S0007114508911570

Article  CAS  PubMed  Google Scholar 

Gupta I, Serva Peddha M (2024) Characterization of polyphenols profile, antioxidant, and in vitro activities of Nigella sativa L. (black cumin) seed oleoresin. Journal of Food Measurement and Characterization, 0123456789. https://doi.org/10.1007/s11694-023-02311-x

Haas MJ, Onstead-Haas LM, Naem E, Wong NCW, Mooradian AD (2014) Induction of apolipoprotein A-I gene expression by black seed (Nigella sativa) extracts. Pharm Biol 52(9):1119–1127. https://doi.org/10.3109/13880209.2013.879187

Article  PubMed  Google Scholar 

Harphoush S, Wu G, Qiuli G, Zaitoun M, Ghanem M, Shi Y, Le G (2019) Thymoquinone ameliorates obesity-induced metabolic dysfunction, improves reproductive efficiency exhibiting a dose-organ relationship. Syst Biology Reproductive Med 65(5):367–382. https://doi.org/10.1080/19396368.2019.1626933

Article  CAS  Google Scholar 

Jeon T, Hwang SG, Hirai S, Matsui T, Yano H, Kawada T, Lim BO, Park DK (2004) Red yeast rice extracts suppress adipogenesis by down-regulating adipogenic transcription factors and gene expression in 3T3-L1 cells. Life Sci 75(26):3195–3203. https://doi.org/10.1016/j.lfs.2004.06.012

Article  CAS  PubMed  Google Scholar 

Karandrea S, Yin H, Liang X, Slitt AL, Heart EA (2017) Thymoquinone ameliorates diabetic phenotype in Diet-Induced obesity mice via activation of SIRT-1-dependent pathways. PLoS ONE 12(9):1–19. https://doi.org/10.1371/journal.pone.0185374

Article  CAS  Google Scholar 

Kong CS, Kim JA, Kim SK (2009) Anti-obesity effect of sulfated glucosamine by AMPK signal pathway in 3T3-L1 adipocytes. Food Chem Toxicol 47(10):2401–2406. https://doi.org/10.1016/j.fct.2009.06.010

Article  CAS  PubMed  Google Scholar 

Lee JA, Cho YR, Hong SS, Ahn EK (2017) Anti-obesity activity of Saringosterol isolated from Sargassum muticum (Yendo) Fensholt Extract in 3T3-L1 cells. Phytother Res 31(11):1694–1701. https://doi.org/10.1002/ptr.5892

Article  CAS  PubMed  Google Scholar 

Licari M, Raffaele M, Rosman ZF, Schragenheim J, Bellner L, Vanella L (2019) Beneficial effects of Thymoquinone on metabolic function and fatty liver in a murine model of obesity. J Food Nutri Sci 9(June):751. https://doi.org/10.4172/2155-9600.1000751

Article  Google Scholar 

Mahmoudi A, Ghatreh Samani K, Farrokhi E, Heidarian E (2018) Effects of Nigella sativa extracts on the lipid Profile and Uncoupling Protein-1 gene expression in Brown Adipose tissue of mice. Adv Biomedical Res 7(1):121. https://doi.org/10.4103/abr.abr_91_18

Article  CAS  Google Scholar 

Moon HS, Chung CS, Lee HG, Kim TG, Choi YJ, Cho CS (2007) Inhibitory effect of (-)-epigallocatechin-3-gallate on lipid accumulation of 3T3-L1 cells. Obesity 15(11):2571–2582. https://doi.org/10.1038/oby.2007.309

Article  CAS  PubMed  Google Scholar 

Morrison RF, Farmer SR (2000) Hormonal signaling and transcriptional control of adipocyte differentiation. J Nutr 130(12):3116–3121. https://doi.org/10.1093/jn/130.12.3116s

Article  Google Scholar 

Palmer DG, Rutter GA, Tavaré JM (2002) Insulin-stimulated fatty acid synthase gene expression does not require increased sterol response element binding protein 1 transcription in primary adipocytes. Biochem Biophys Res Commun 291(3):439–443. https://doi.org/10.1006/bbrc.2002.6467

Article  CAS  PubMed  Google Scholar 

Park HJ, Cho JY, Kim MK, Koh PO, Cho KW, Kim CH, Lee KS, Chung BY, Kim GS, Cho JH (2012) Anti-obesity effect of Schisandra chinensis in 3T3-L1 cells and high fat diet-induced obese rats. Food Chem 134(1):227–234. https://doi.org/10.1016/j.foodchem.2012.02.101

Article  CAS  Google Scholar 

Park M, Sharma A, Lee HJ (2019) Anti-adipogenic effects of delphinidin-3-O-β-glucoside in 3T3-L1 preadipocytes and primary white adipocytes. Molecules 24(10):1–12. https://doi.org/10.3390/molecules24101848

Article  CAS  Google Scholar 

Rai C, Nandini CD, Priyadarshini P (2021) Composition and structure elucidation of bovine milk glycosaminoglycans and their anti-adipogenic activity via modulation PPAR-γ and C/EBP-α. Int J Biol Macromol 193(PA):137–144. https://doi.org/10.1016/j.ijbiomac.2021.10.076

Article  CAS  PubMed  Google Scholar 

Shahbodi M, Emami SA, Javadi B, Tayarani-Najaran Z (2022) Effects of Thymoquinone on Adipocyte differentiation in human adipose-derived stem cells. Cell Biochem Biophys 80(4):771–779. https://doi.org/10.1007/s12013-022-01095-z

Article  CAS  PubMed  Google Scholar 

Shen HH, Peterson SJ, Bellner L, Choudhary A, Levy L, Gancz L, Sasson A, Trainer J, Rezzani R, Resnick A, Stec DE, Abraham NG (2020) Cold-pressed nigella sativa oil standardized to 3% thymoquinone potentiates omega-3 protection against obesity-induced oxidative stress, inflammation, and markers of insulin resistance accompanied with conversion of white to beige fat in mice. Antioxidants 9(6):1–19. https://doi.org/10.3390/antiox9060489

Article  CAS  Google Scholar 

Spiegelman BM, Flier JS (1996) Adipogenesis and obesity: rounding out the big picture. Cell 87(3):377–389. https://doi.org/10.1016/S0092-8674(00)81359-8

Article  CAS  PubMed  Google Scholar 

Spiegelman BM, Flier JS (2001) Obesity and the Regulation Review of Energy Balance total fast of approximately 150 days! This impressive energy reserve is due both to the high energy content of triglycerides versus polysaccharides, and the fact. Cell 104:531–543

Article  CAS  PubMed  Google Scholar 

Sung HY, Kang SW, Kim JL, Li J, Lee ES, Gong JH, Han SJ, Kang YH (2010) Oleanolic acid reduces markers of differentiation in 3T3-L1 adipocytes. Nutr Res 30(12):831–839. https://doi.org/10.1016/j.nutres.2010.10.001

Article  CAS  PubMed  Google Scholar 

Suzuki R, Tanaka M, Takanashi M, Hussain A, Yuan B, Toyoda H, Kuroda M (2011) Anthocyanidins-enriched bilberry extracts inhibit 3T3-L1 adipocyte differentiation via the insulin pathway. Nutr Metabolism 8:1–9. https://doi.org/10.1186/1743-7075-8-14

Article  CAS  Google Scholar 

White UA, Stephens JM (2010) Transcriptional factors that promote formation of white adipose tissue. Mol Cell Endocrinol 318(1–2):10–14. https://doi.org/10.1016/j.mce.2009.08.023

Article  CAS  PubMed  Google Scholar 

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