Al-Bari MAA, Ito Y, Ahmed S, Radwan N, Ahmed HS, Eid N (2021) Targeting autophagy with natural products as a potential therapeutic approach for cancer. Int J Mol Sci 22(18):9807. https://doi.org/10.3390/ijms22189807
Article CAS PubMed PubMed Central Google Scholar
Baskić D, Popović S, Ristić P, Arsenijević NN (2006) Analysis of cycloheximide-induced apoptosis in human leukocytes: fluorescence microscopy using annexin V/propidium iodide versus acridine orange/ethidium bromide. Cell Biol Int 30(11):924–932
Bowers, KJ, Chow E, Xu H, Dror RO, Eastwood MP, Gregersen BA, Klepeis J, Kolossvary I, Moraes MA, Sacerdoti FD, Salmon JK, Shan Y, Shaw D (2006) In: Proceedings of the ACM/IEEE conference on supercomputing (SC06), November 11–17
Cova D, De Angelis L, Monti E (1992) Piccinini F (1992) Subcellular distribution of two spin trapping agents in rat heart: possible explanation for their different protective effects against doxorubicin-induced cardiotoxicity. Free Rad Res Commun 15:353–360
Cunha-Oliveira T, Ferreira LL, Coelho AR, Deus CM, Oliveira PJ (2018) Doxorubicin triggers bioenergetic failure and p53 activation in mouse stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol 348:1–13
Article CAS PubMed Google Scholar
Daina A, Michielin O, Zoete V (2017) SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Sci Rep 7:42717
Article PubMed PubMed Central Google Scholar
Davies KJ, Doroshow JH (1986) Redox cycling of anthracyclines by cardiac mitochondria. I. Anthracycline radical formation by NADH dehydrogenase. J Biol Chem 261:3060–3067
Article CAS PubMed Google Scholar
Ding M, Shi R, Cheng S, Li M, De D, Liu C, Gu X, Li J, Zhang S, Jia M, Fan R, Pei J, Fu F (2022) Mfn2-mediated mitochondrial fusion alleviates doxorubicin-induced cardiotoxicity with enhancing its anticancer activity through metabolic switch. Redox Biol 52:102311
Article CAS PubMed PubMed Central Google Scholar
Doroshow JH, Davies KJ (1986) Redox cycling of anthracyclines by cardiac mitochondria. II. Formation of superoxide anion, hydrogen peroxide, and hydroxyl radical. J Biol Chem 261:3068–3074
Article CAS PubMed Google Scholar
Drwal MN, Banerjee P, Dunkel M, Wettig MR, Preissner R (2014) ProTox: a web server for the in silico prediction of rodent oral toxicity. Nucleic Acids Res 42(W1):W53-58
Article CAS PubMed PubMed Central Google Scholar
El-Agamy DS, El-Harbi KM, Khoshhal S, Ahmed N, Elkablawy MA, Shaaban AA, Abo-Haded HM (2018) Pristimerin protects against doxorubicin-induced cardiotoxicity and fibrosis through modulation of Nrf2 and MAPK/NF-kB signaling pathways. Cancer Manag Res 11:47–61
Article PubMed PubMed Central Google Scholar
Han X, Pan J, Ren D, Cheng Y, Fan P, Lou H (2008) Naringenin-7-O-glucoside protects against doxorubicin-induced toxicity in H9c2 cardiomyocytes by induction of endogenous antioxidant enzymes. Food Chem Toxicol 46(9):3140–3146
Article CAS PubMed Google Scholar
Harder E, Damm W, Maple J, Wu C, Reboul M, Xiang JY, Wang L, Lupyan D, Dahlgren MK, Knight JL, Kaus JW, Cerutti DS, Krilov G, Jorgensen WL, Abel R, Friesner RA (2016) OPLS3: a force field providing broad coverage of drug-like small molecules and proteins. J Chem Theory Comp 12(1):281–296
Karin M (1999) How NF-кß is activated: the role of the IkappaB kinase (IKK) complex. Oncogene 18(49):6867–6874
Article CAS PubMed Google Scholar
Kelleni MT, Amin EF, Abdelrahman AM (2015) Effect of metformin and sitagliptin on doxorubicin-induced cardiotoxicity in rats: impact of oxidative stress, inflammation, and apoptosis. J Toxicol. https://doi.org/10.1155/2015/424813
Article PubMed PubMed Central Google Scholar
Lagouge M, Argmann C, Gerhart-Hines Z et al (2006) Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α. Cell 127(6):1109–1122
Article CAS PubMed Google Scholar
Larsson NG, Wang J, Wilhelmsson H, Oldfors A, Rustin P, Lewandoski M, Barsh GS, Clayton DA (1998) Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice. Nature Gen 18(3):231–236
Laskar YB, Mazumder PB, Talukdar AD (2023) Hibiscus sabdariffa anthocyanins are potential modulators of estrogen receptor alpha activity with favourable toxicology: a computational analysis using molecular docking, ADME/Tox prediction, 2D/3D QSAR and molecular dynamics simulation. J Biomol Struct Dyn 41(2):611–633
Article CAS PubMed Google Scholar
Linders AN, Dias IB, López Fernández T, Tocchetti CG, Bomer N, Van der Meer P (2024) A review of the pathophysiological mechanisms of doxorubicin-induced cardiotoxicity and aging. NPJ Aging 10(1):9
Article PubMed PubMed Central Google Scholar
Liu D, Ma Z, Di S, Yang Y, Yang J, Xu L, Reiter RJ, Qiao S, Yuan J (2018) AMPK/PGC1α activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis. Free Rad Biol Med 129:59–72
Article CAS PubMed Google Scholar
Minotti G, Menna P, Salvatorelli E, Cairo G, Gianni L (2004) Anthracyclines: Molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev 56(2):185–229
Article CAS PubMed Google Scholar
Neog MK, Joshua Pragasam S, Krishnan M, Rasool M (2017) p-Coumaric acid, a dietary polyphenol ameliorates inflammation and curtails cartilage and bone erosion in the rheumatoid arthritis rat model. BioFactors (Oxford, England) 43(5):698–717
Article CAS PubMed Google Scholar
Nordgren KKS, Wallace KB (2020) Disruption of the Keap1/Nrf2-Antioxidant response system after chronic doxorubicin exposure in vivo. Cardiovasc Toxicol 20(6):557–570
Article CAS PubMed Google Scholar
Pei K, Ou J, Huang J, Ou S (2016) p-Coumaric acid and its conjugates: dietary sources, pharmacokinetic properties and biological activities. J Sci Food Agri 96(9):2952–2962
Ponnian SMP, Stanely SP, Roy AJ (2024) Cardioprotective effects of p-coumaric acid on tachycardia, inflammation, ion pump dysfunction, and electrolyte imbalance in isoproterenol-induced experimental myocardial infarction. J Biochem Mol Toxicol 38(3):e23668
Article CAS PubMed Google Scholar
Rimando AM, Nagmani R, Feller DR, Yokoyama W (2005) Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor alpha-isoform, lowers lipoproteins and cholesterol in hypercholesterolemic hamsters. J Agri Food Chem 53(9):3403–3407
Rodríguez-Roque MJ, de Ancos B, Sánchez-Moreno C, Cano MP, Elez-Martínez P (2021) Phenolic compounds in food: characterization and health benefits. J Food Comp Anal 97:103773
Rowe GC, Jiang A, Arany Z (2010) PGC-1 coactivators in cardiac development and disease. Circ Res 107(7):825–838
Article CAS PubMed PubMed Central Google Scholar
Studneva I, Palkeeva M, Veselova O, Molokoedov A, Ovchinnikov M, Sidorova M, Pisarenko O (2019) Protective effects of a novel agonist of galanin receptors against doxorubicin-induced cardiotoxicity in rats. Cardiovasc Toxicol 19:136–146
Article CAS PubMed Google Scholar
Sunitha MC, Dhanyakrishnan R, PrakashKumar B, Nevin KG (2018) p-Coumaric acid-mediated protection of H9c2 cells from Doxorubicin-induced cardiotoxicity: Involvement of augmented Nrf2 and autophagy. Biomed Pharmacother 102:823–832
Article CAS PubMed Google Scholar
Tacar O, Sriamornsak P, Dass CR (2013) Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems. J Pharm Pharmacol 65(2):157–170
Article CAS PubMed Google Scholar
Tadokoro T, Ikeda M, Ide T, Deguchi H, Ikeda S, Okabe K, Ishikita A, Matsushima S, Koumura T, Yamada KI, Imai H, Tsutsui H (2020) Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity. JCI Insight 5(9):e132747
Comments (0)