Novel in vitro model for intravitreal drug dissolution and release studies of small molecules and their long-acting formulations

AMD

Age-related macular degeneration

Clpred

Predicted vitreal clearance

Clexp

Experimental vitreal clearance in literature

HD

Hydrogen bond donor count

HPLC

High-performance liquid chromatography

IVIVC

In vitro – in vivo correlation

ke

Elimination rate constant

Log D7.4

Octanol/water partition coefficient at pH 7.4

NHV

Non-homogenized vitreous

PBS

Phosphate-buffered saline

PCA

Principal component analysis

QSPR

Quantitative structure property relationship

TA

Triamcinolone acetonide

UV–Vis

Ultraviolet-visible light spectroscopy

Vd

Volume of distribution.

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