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Glutathione-responsive self-assembling peptide-coated Salmonella for antitumor therapy
Cancer imposes an ever-growing global health challenge, with over 19 million new diagnoses in 2020 and projections exceedi...
Loading of therapeutic cell penetrating peptides into extracellular vesicles for pulmonary fibrosis
Volume 390, 10 February 2026, 114561Author links open overlay panel, , , , , , AbstractExtracellular vesicles (EVs) are he...
Inhalable nanosystem promote in situ packaging of IL-11 antisense oligonucleotides into macrophage-derived vesicles for idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a progressive and debilitating lung disorder characterized by activated fibroblast ...
Hepatocyte-specific partial cellular reprogramming via selective OSK mRNA lipid nanoparticle attenuates liver fibrosis
The ability to transiently modulate cell identity in vivo using non-integrating mRNA technology presents a transformative ...
Octopus-inspired polymeric nanovaccine enables high antigen loading and robust T cell activation for cancer immunotherapy
Therapeutic vaccines represent a promising strategy for cancer immunotherapy and have garnered considerable attention [[1]...
Multifunctional microfluidic-directed polymer/hydrogel fabrics towards pH-responsive drug delivery, wound monitoring and wearable sensing
Skin acts as the largest organ of human body that undertakes several crucial tasks, such as safeguarding the inner body sy...
Engineered nanoparticles for subconjunctival delivery to the retinal pigment epithelium: A multi-target therapy for dry AMD
Dry age-related macular degeneration (dAMD) is a leading cause of irreversible blindness, driven by oxidative stress-induc...
Nanochirality-programmed type-I photosensitizer enables deep-tumor photodynamic therapy by reducing extracellular-matrix adhesion
Tumor hypoxia and poor penetration of therapeutics across tumor-microenvironment barriers remain major obstacles to effect...
Localized inflammasome inhibition mitigates foreign body response to subcutaneous long-acting antiretroviral therapy for HIV
Long-acting antiretroviral therapy (LA-ART) holds promise for improving adherence and viral suppression in human immunodef...
Corrigendum to ‘90 K increased delivery efficiency of extracellular vesicles through mediating internalization’ [Journal of Controlled Release 353 (2023) 930–942]
Volume 390, 10 February 2026, 114510Author links open overlay panelGuiquan Zhu a, Fan Yang a, Hongxuan Wei a, Wanrong Meng...
Guanidinylated polymers enable safe and efficient dsRNA delivery in plant cells
The widespread use of chemical pesticides in crop protection poses serious environmental risks and has been associated wit...
Biomimetic siRNA therapeutics attenuate mitochondrial DNA damage and cytokine storm in sepsis
Sepsis is a life-threatening organ dysfunction caused by dysregulated host responses to infection [1], primarily driven by...
Understanding excipient interactions unlocks untapped potential of RNA-lipid nanoparticles in dry powder formulations for local pulmonary delivery
Small interfering RNA (siRNA)-loaded lipid nanoparticles (LNPs) are a promising modality for gene silencing therapies. Pul...
Biodynamers as prodrugs with controlled uptake and activity
Chemotherapy is one of the primary approaches for cancer treatment. However, its toxicity to healthy tissue often causes s...
Antigen-conjugated scaffolds enable sustained delivery of antigen and enrichment of antigen-specific T-cells
A thorough understanding of T-cell dynamics and interactions could improve patient care in autoimmunity, cancer immunother...
Enzyme-coupled polymersome microreactor for point-of-care blood urea sensing
Vesicular microreactors have gained broad interest in drug delivery, biodetoxification, and green chemistry. We have expan...
Machine learning-driven insights into the mechanical performance of polymeric microneedle array patches
Being minimally invasive, microneedles (MNs) are emerging as a promising technology for transporting active substances int...
Combined M1 macrophage inhibition and thermotherapy for controlled fibroplasia and accelerated wound repair via an oxygenating ROS-responsive hydrogel
Wound healing remains a major clinical challenge, as hypoxia, oxidative stress, and immune dysregulation collectively impe...
Supramolecular antioxidant conductive injectable hydrogel encapsulating L-arginine for synergistic modulation of myocardial infarction
Myocardial infarction (MI) poses a significant health threat worldwide, showing persistently high mortality and morbidity ...
Escherichia coli Nissle 1917 outer membrane vesicles encapsulating oncolytic virus remodel tumor-associated macrophages and kill prostate cancer cells
Prostate cancer (PCa) is the most common malignancy in the male genitourinary system globally, with approximately 1.6 mill...
An injectable hydrogel enhances intratumoral retention and antitumor efficacy of cytokine immunotherapy in murine triple negative breast tumor models
Systemic delivery of immunotherapy is dose-limited and often causes serious immune-related adverse events. Intratumoral in...
Metal-phenolic epigallocatechin gallate‑zinc antioxidant nanoparticles for cataract treatment
Globally, age-related cataracts are one of the main causes of visual impairment and blindness [1,2]. With the increasing a...
Hypoxia-responsive albumin nanoparticles co-delivering banoxantrone and STING agonist enhance immunotherapy of high-intensity focused ultrasound
High-intensity focused ultrasound (HIFU), as a non-invasive breast-conserving method, has led to revolutionary changes in ...
Cardiosplenic axis-targeted immunomodulatory liposome for myocardial ischemia-reperfusion injury treatment
Jiankai Dong: Writing – original draft, Methodology, Investigation, Funding acquisition, Formal analysis, Data curation. Z...
Delivery of Itgb1-siRNA by triptolide-modified and anti-Flt1 peptide-guided ionizable cationic LNPs for targeted therapy of corneal neovascularization
A robust cornea constitutes a transparent and avascular tissue situated on the ocular surface, maintaining its transparenc...
Targeted eradication of glioblastoma via venom decapeptide-conjugated dendrimers: Inducing nuclear translocation and autophagic cell death
Glioblastoma (GBM) is one of the most aggressive central nervous system tumors, accounting for nearly 49 % of all intracra...
Metal phenolic networks-driven bufalin homodimeric prodrug nano-coassemblies for ferroptosis-augmented tumor therapy
Bufalin (BF), a pivotal active constituent of the traditional Chinese medicine (TCM) cinobufacini, has exhibited potent an...
Novel in vitro model for intravitreal drug dissolution and release studies of small molecules and their long-acting formulations
AMDAge-related macular degenerationClpredPredicted vitreal clearanceClexpExperimental vitreal clearance in literatureHDHyd...
Impact of pre-existing anti-polyethylene glycol (PEG) IgM on biodistribution and humoral response of intramuscularly administered PEGylated mRNA loaded lipid nanoparticle
World-wide administration of intramuscular (i.m.) mRNA-based vaccines, mRNA-1273 and BNT162b2 for SARS-CoV-2, have proven ...
Homologous magnetic targeted immune vesicles for amplifying immunotherapy via ferroptosis activation augmented photodynamic therapy against glioblastoma
As one of the most aggressive malignant tumors, glioblastoma (GBM) has optimal treatment mainly relying on surgical resect...
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