Ahamad A, Kumar J (2023) Pyrethroid pesticides: an overview on classification, toxicological assessment and monitoring. J Hazardous Mater Adv 10:100284–100284. https://doi.org/10.1016/j.hazadv.2023.100284

Article  CAS  Google Scholar 

Andersen HR, David A, Freire C, Fernández MF, D’Cruz SC, Reina-Pérez I, Fini J-B, Blaha L (2022a) Pyrethroids and developmental neurotoxicity—a critical review of epidemiological studies and supporting mechanistic evidence. Environ Res 214:113935. https://doi.org/10.1016/j.envres.2022.113935

Article  CAS  PubMed  Google Scholar 

Andersen HR, Rambaud L, Riou M, Buekers J, Remy S, Berman T, Govarts E (2022b) Exposure levels of Pyrethroids, Chlorpyrifos and Glyphosate in EU—an overview of human biomonitoring studies published since 2000. Toxics 10(12):789–789. https://doi.org/10.3390/toxics10120789

Article  CAS  PubMed  PubMed Central  Google Scholar 

AOP-Wiki (n.d.). Aopwiki.org. https://aopwiki.org/

Aznar-Alemany Ò, Eljarrat E (2020a) Introduction to Pyrethroid Insecticides: Chemical Structures, Properties, Mode of Action and Use. In: Eljarrat E (ed) Pyrethroid Insecticides. The Handbook of Environmental Chemistry, vol 92. Springer, Cham

Google Scholar 

Aznar-Alemany Ò, Eljarrat E (2020b) Bioavailability and Bioaccumulation of Pyrethroid Insecticides in Wildlife and Humans. The Handbook of Environmental Chemistry, pp 205–225

Google Scholar 

Ball N, Bars R, Botham PA, Cuciureanu A, Cronin MTD, Doe JE, Dudzina T, Gant TW, Leist M, van Ravenzwaay B (2022) A framework for chemical safety assessment incorporating new approach methodologies within REACH. Arch Toxicol 96(3):743–766. https://doi.org/10.1007/s00204-021-03215-9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bean TG, Beasley VR, Berny P, Eisenreich KM, Elliott JE, Eng ML, Fuchsman PC, Johnson MS, King MD, Soria RM, Meyer CB, Salice CJ, Rattner BA (2023) Toxicological effects assessment for wildlife in the 21st century: review of current methods and recommendations for a path forward. Integr Environ Assess Manag. https://doi.org/10.1002/ieam.4795

Article  PubMed  Google Scholar 

Bearth A, Roth N, Jansen T, Holden L, Čavoški A, Di Consiglio E, Hauzenberger I, Lee R, Mombelli E, Tcheremenskaia O, Wendt-Rasch L, Wilks MF (2025) New approach methodologies in human health risk assessment across European regulatory frameworks: Status quo, barriers and drivers for regulatory acceptance and use. Environ Int 196:109279. https://doi.org/10.1016/j.envint.2025.109279

Article  CAS  PubMed  Google Scholar 

Becker RA, Plunkett LM, Borzelleca JF, Kaplan AM (2007) Tiered toxicity testing: Evaluation of toxicity-based decision triggers for human health hazard characterization. Food Chem Toxicol 45(12):2454–2469. https://doi.org/10.1016/j.fct.2007.05.030

Article  CAS  PubMed  Google Scholar 

Bell SM, Chang X, Wambaugh JF, Allen DG, Bartels M, Brouwer KLR, Casey WM, Choksi N, Ferguson SS, Fraczkiewicz G, Jarabek AM, Ke A, Lumen A, Lynn SG, Paini A, Price PS, Ring C, Simon TW, Sipes NS, Sprankle CS (2018) In vitro to in vivo extrapolation for high throughput prioritization and decision making. Toxicol in Vitro 47:213–227. https://doi.org/10.1016/j.tiv.2017.11.016

Article  CAS  PubMed  Google Scholar 

Bhateria M, Taneja I, Karsauliya K, Sonker AK, Shibata Y, Sato H, Singh SP, Hisaka A (2024) Predicting the in vivo developmental toxicity of fenarimol from in vitro toxicity data using PBTK modelling-facilitated reverse dosimetry approach. Toxicol Appl Pharmacol 484:116879. https://doi.org/10.1016/j.taap.2024.116879

Article  CAS  PubMed  Google Scholar 

Bossier H, Chau J, Ndour C, Varewyck M, Verbeke T, Vergucht S (2020) A Web-based open source tool for Toxicokinetic and Toxicodynamic modelling. EFSA Support Publ. https://doi.org/10.2903/sp.efsa.2020.en-1926

Article  Google Scholar 

Carramusa L., Mune W., Hunt, N., Browne, L., Osborne, O.x, & Potter, C. (2024). New Approach Methodologies (NAMs) to Support Regulatory Decisions for Chemical Safety. FSA Research and Evidence. https://doi.org/10.46756/001c.122591

Casati S (2018) Integrated approaches to testing and assessment. Basic Clin Pharmacol Toxicol 123:51–55. https://doi.org/10.1111/bcpt.13018

Article  CAS  PubMed  Google Scholar 

Cattaneo I, Astuto MC, Binaglia M, Devos Y, Dorne JLCM, Fernandez Agudo A, Fernandez Dumont A, Garcia-Vello P, Kass GEN, Lanzoni A, Liem AKD, Panzarea M, Paraskevopulos K, Parra Morte JM, Tarazona JV, Terron A (2023) Implementing new approach methodologies (NAMs) in food safety assessments: Strategic objectives and actions taken by the European Food Safety Authority. Trends Food Sci Technol 133:277–290. https://doi.org/10.1016/j.tifs.2023.02.006

Article  CAS  Google Scholar 

Cedergreen N, Dalhoff K, Li D, Gottardi M, Kretschmann AC (2017) Can toxicokinetic and toxicodynamic modeling be used to understand and predict synergistic interactions between chemicals? Environ Sci Technol 51(24):14379–14389. https://doi.org/10.1021/acs.est.7b02723

Article  CAS  PubMed  Google Scholar 

Chłodowska A, Pietruk K, Protasiuk E, Olejnik M (2024) Risk assessment of residues of coccidiostats in food 14 years after the introduction of maximum levels. Food Control 164:110557. https://doi.org/10.1016/j.foodcont.2024.110557

Article  CAS  Google Scholar 

CompTox Chemicals Dashboard (2024). Epa.gov. https://comptox.epa.gov/dashboard/

Corley SM, Mendoza-Reinoso V, Giles N, Singer ES, Common JEA, Wilkins MR, Beverdam A (2018) Plau and Tgfbr3 are YAP-regulated genes that promote keratinocyte proliferation. Cell Death Dis. https://doi.org/10.1038/s41419-018-1141-5

Article  PubMed  PubMed Central  Google Scholar 

Coussens LM, Tinkle CL, Hanahan D, Werb Z (2000) MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell 103(3):481–490. https://doi.org/10.1016/s0092-8674(00)00139-2

Article  CAS  PubMed  PubMed Central  Google Scholar 

Crivellente F, Hart A, Hernandez-Jerez AF, Bennekou SH, Pedersen R, Terron A, Wolterink G, Mohimont L (2019) Establishment of cumulative assessment groups of pesticides for their effects on the thyroid. EFSA J. https://doi.org/10.2903/j.efsa.2019.5801

Article  PubMed  PubMed Central  Google Scholar 

De Alba-Gonzalez M, González-Caballero MC, Tarazona JV (2023) Applicability of food monitoring data for assessing relative exposure contributions of pyrethroids in retrospective human biomonitoring risk estimations. Toxics 12(1):24–24. https://doi.org/10.3390/toxics12010024

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dinse GE, Umbach DM (2011) Characterizing non-constant relative potency. Regul Toxicol Pharmacol 60(3):342–353. https://doi.org/10.1016/j.yrtph.2011.05.002

Article  CAS  PubMed  PubMed Central  Google Scholar 

Djekic I, Smigic N, Tomic N, Sredojevic A, Stevic M, Vrbnicanin S, Radusin K, Udovicki B (2024) Exposure assessment of young adults to pesticides that have effects on the thyroid—a contribution to “One Health.” Appl Sci 14(2):880–880. https://doi.org/10.3390/app14020880

Article  CAS  Google Scholar 

Doménech E, Martorell S (2024) Review of the terminology, approaches, and formulations used in the guidelines on quantitative risk assessment of chemical hazards in food. Foods 13(5):714. https://doi.org/10.3390/foods13050714

Article  CAS  PubMed  PubMed Central  Google Scholar 

DrugBank (2024) https://go.drugbank.com/

EC, SCOEL (2013) Methodology for the Derivation of Occupational Exposure Limits Scientific Committee on Occupational Exposure Limits (SCOEL). https://ec.europa.eu/social/BlobServlet?docId=4526&langId=en

ECHA (2011) Evaluation report according to Directive 98/8/EC of active substance Deltamethrin Product-type 18. https://echa.europa.eu/documents/10162/2636afe0-209e-e92f-2255-7392b2c79145

ECHA (2014) Evaluation report according to Regulation 528/2012 of active substance Permethrin Product-Type 18. https://echa.europa.eu/documents/10162/ff18b40c-e4f6-469e-377d-6e5aca835bd2

ECHA (2017) Evaluation report according to Regulation 528/2012 of active substance Cypermethrin Product-type 18. https://echa.europa.eu/documents/10162/716f554b-b973-1a61-5bf2-eff87b36a237

ECHA (2018) Evaluation report according to Regulation 528/2012 of active substance Cyfluthrin Product-type 18. https://echa.europa.eu/documents/10162/965f85c8-07b0-dad7-83dc-ce32039307db

EFSA (2011) Peer Review of the pesticide risk assessment of the active substance Bifenthrin. European Food Safety Authority. https://www.efsa.europa.eu/en/efsajournal/pub/2159

EFSA (2014) Peer review of the pesticide risk assessment of the active substance Lambda-Cyhalothrin. European Food Safety Authority. https://www.efsa.europa.eu/en/efsajournal/pub/3677

EFSA (2023) Margin of Exposure. European Food Safety Authority. https://www.efsa.europa.eu/en/topics/topic/margin-exposure#published-on-this-topic

Elena R, Jeddi MZ, Paini A, Connolly A, Duca R, Cubadda F, Benfenati E, Bessems J, Galea KS, Dirven H, Santonen T, Koch HM, Jones K, Sams C, Viegas S, Kyriaki M, Campisi L, David A, Antignac J-P, Hopf NB (2024) Human biomonitoring and toxicokinetics as key building blocks for next generation risk assessment. Environ Int. https://doi.org/10.1016/j.envint.2024.108474

Article  Google Scholar 

Ernst G, Amorim MJ, Bottoms M, Brooks AC, Hodson ME, Kimmel S, Kotschik P, Marx MT, Natal-da-Luz T, Pelosi C, Pieper S (2023) Intermediate-tier options in the environmental risk assessment of plant protection products for soil invertebrates—synthesis of a workshop. Integr Environ Assess Manag 20(3):780–793. https://doi.org/10.1002/ieam.4825

Article  PubMed  Google Scholar