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Exploring the potential of liver microphysiological systems of varied configurations to model cholestatic chemical effects
Exploring the potential of liver microphysiological systems of varied configurations to model cholestatic chemical effects
Human in vitro liver tissue models have evolved to maintain hallmarks of hepatocellular function for extended periods with...
Scorpion venom as a molecular treasure: emerging bioactive compounds and translational therapeutic insights
Scorpion venom as a molecular treasure: emerging bioactive compounds and translational therapeutic insights
Scorpion venom contains a diverse array of bioactive compounds, including peptides, proteins, enzymes, and alkaloids, whic...
3,3'-Dichlorobiphenyl (PCB 11) alters the hepatic expression of cytochrome P450 enzymes in the liver of mouse dams exposed orally during pregnancy and lactation
3,3'-Dichlorobiphenyl (PCB 11) alters the hepatic expression of cytochrome P450 enzymes in the liver of mouse dams exposed orally during pregnancy and lactation
Healthy maternal metabolism is critical during pregnancy and lactation to support fetal development and protect against en...
Mechanism of liver fibrosis induced by life-long triclosan exposure in offspring rats: an adverse outcome pathway framework validated by in vivo and in vitro experiments
Mechanism of liver fibrosis induced by life-long triclosan exposure in offspring rats: an adverse outcome pathway framework validated by in vivo and in vitro experiments
Triclosan (TCS), a broad-spectrum lipophilic antiseptic, is frequently found in household and healthcare supplies. Its inc...
Cross-ancestry meta-analysis identifies a variant in the polycyclic aromatic hydrocarbons metabolism-related pathway contributing to colorectal cancer susceptibility
Cross-ancestry meta-analysis identifies a variant in the polycyclic aromatic hydrocarbons metabolism-related pathway contributing to colorectal cancer susceptibility
Unhealthy diets (e.g., higher red meat consumption) and tobacco exposure are major risk factors for colorectal cancer (CRC...
SARS-CoV-2 mRNA vaccines: unresolved mechanisms of myocardial damage
SARS-CoV-2 mRNA vaccines: unresolved mechanisms of myocardial damage
Myopericarditis requiring emergency care or hospitalization after COVID-19 mRNA vaccination occurs most frequently in adol...
Insights into the human metabolism and in silico receptor activity of gidazepam and desalkylgidazepam
Insights into the human metabolism and in silico receptor activity of gidazepam and desalkylgidazepam
Desalkylgidazepam, an active gidazepam metabolite, first appeared on the illicit drug market in 2022 and has been detected...
Correction: Effect of ‑acetyltransferase 2 genetic polymorphism on 4,4′‑methylenebis(2‑chloroaniline)‑induced genotoxicity and oxidative stress
Correction: Effect of ‑acetyltransferase 2 genetic polymorphism on 4,4′‑methylenebis(2‑chloroaniline)‑induced genotoxicity and oxidative stress
Cite this articleHabil, M.R., Salazar‑González, R.A., Doll, M.A. et al. Correction: Effect of N‑acetyltransferase 2 geneti...
Toxicological profiling of venoms from ten major Chinese snakes: a mass spectrometry-based proteomic and multiroute assessment
Toxicological profiling of venoms from ten major Chinese snakes: a mass spectrometry-based proteomic and multiroute assessment
Snake envenomation, a neglected tropical disease, presents complex and species-dependent systemic pathophysiology. Here, w...
Qualitative and quantitative in silico toxicity profiling of “angel dust”: phencyclidine (PCP) analogues as new psychoactive substances (3-HO-PCP, 3-MeO-PCP, 4-MeO-PCP, 3-HO-PCE, 3-MeO-PCE, 4-MeO-PCE)
Qualitative and quantitative in silico toxicity profiling of “angel dust”: phencyclidine (PCP) analogues as new psychoactive substances (3-HO-PCP, 3-MeO-PCP, 4-MeO-PCP, 3-HO-PCE, 3-MeO-PCE, 4-MeO-PCE)
Phencyclidine (PCP), historically known as “angel dust,” and its analogues (3-HO-PCP, 3-MeO-PCP, 4-MeO-PCP, 3-...
Projection-based molecular feature maps for CNN-driven nephrotoxicity prediction
Projection-based molecular feature maps for CNN-driven nephrotoxicity prediction
The development of reliable predictive models for nephrotoxic agents remains a critical challenge in drug development, giv...
Mechanism-based new approach methodologies for in vitro detection of chemical-induced liver steatosis
Mechanism-based new approach methodologies for in vitro detection of chemical-induced liver steatosis
Liver steatosis resulting from chemical exposure is a growing clinical concern, pointing to the need for early detection i...
Health impacts of micro- and nanoplastics: key influencing factors, limitations, and future perspectives
Health impacts of micro- and nanoplastics: key influencing factors, limitations, and future perspectives
Micro- and nanoplastics (MNPs) are emerging environmental threats, with increasing evidence of their profound ecotoxicolog...
New approach methodologies for metabolic disruption: a high-throughput human liver cell phospholipidosis assay
New approach methodologies for metabolic disruption: a high-throughput human liver cell phospholipidosis assay
Phospholipidosis (PLD) is the excessive accumulation of phospholipids within cells, which is, for example, observed in the...
Perfluorooctanoic acid and perfluorooctane sulfonate promote osteoclastogenesis in vitro through the activation of hemichannels
Perfluorooctanoic acid and perfluorooctane sulfonate promote osteoclastogenesis in vitro through the activation of hemichannels
The current study investigated the effects of two per- and polyfluoroalkyl substances (PFASs) named perfluorooctanoic acid...
Evaluating the stability of synthetic cathinones in liquid urine and dried urine spots: impact of pH and storage conditions
Evaluating the stability of synthetic cathinones in liquid urine and dried urine spots: impact of pH and storage conditions
Synthetic cathinones comprise a class of new psychoactive substances associated with significant morbidity and mortality. ...
Bisphenol Z at environmentally relevant dose dysregulates mitochondrial metabolism and proliferative capacity in human ovarian granulosa cells by inducing changes in metabolic substrate utilization
Bisphenol Z at environmentally relevant dose dysregulates mitochondrial metabolism and proliferative capacity in human ovarian granulosa cells by inducing changes in metabolic substrate utilization
The new generation of bisphenols, including bisphenol AF (BPAF), B (BPB), P (BPP) and Z (BPZ), has been detected within th...
Physiologically based pharmacokinetic modeling of polychlorinated biphenyl-153: cross-species extrapolation and human exposure simulation
Physiologically based pharmacokinetic modeling of polychlorinated biphenyl-153: cross-species extrapolation and human exposure simulation
Polychlorinated biphenyl-153 (PCB-153) is a representative organic pollutant that can accumulate in the human body, partic...
Dipyanone, a new methadone-like synthetic opioid: In vitro and in vivo human metabolism and pharmacological profiling
Dipyanone, a new methadone-like synthetic opioid: In vitro and in vivo human metabolism and pharmacological profiling
The emergence of novel synthetic opioids (NSOs) poses significant challenges to public health, toxicologists, and law enfo...
Invertebrate venoms: A treasure trove of bioactive compounds with anticancer potential
Invertebrate venoms: A treasure trove of bioactive compounds with anticancer potential
Invertebrate venoms, despite their inherent toxicity, represent a promising source of bioactive compounds with significant...
Fibroblast EGFR signaling mediates ricin toxin-induced acute lung injury via EGR1/CXCL1 axis
Fibroblast EGFR signaling mediates ricin toxin-induced acute lung injury via EGR1/CXCL1 axis
Ricin toxin (RT), a highly potent plant-derived toxin, represents a critical threat due to its capacity to induce fatal ac...
Non-oxime reactivators of organophosphate-inhibited cholinesterases
Non-oxime reactivators of organophosphate-inhibited cholinesterases
Organophosphorus compounds, including pesticides and nerve agents, irreversibly inhibit acetylcholinesterase, leading to a...
Carfentanil stabilizes µ opioid receptor conformations that are ultra-efficient in inhibiting cAMP, resistant to naloxone or nalmefene but sensitive to naltrexone
Carfentanil stabilizes µ opioid receptor conformations that are ultra-efficient in inhibiting cAMP, resistant to naloxone or nalmefene but sensitive to naltrexone
The highly potent opioid carfentanil (CAR) represents a growing health risk. CAR acts via Gi/o-coupled µ opioid recep...
Human sperm as an in vitro toxicity model: a versatile tool for assessing the risk of environmental contaminants
Human sperm as an in vitro toxicity model: a versatile tool for assessing the risk of environmental contaminants
Contaminants of emerging concern (CECs) pose a significant threat to human and ecosystem health due to their persistence, ...
Lipogenesis and MASLD: re-thinking the role of SREBPs
Lipogenesis and MASLD: re-thinking the role of SREBPs
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide and a ...
Improving how we use workshops when solving complex research problems: reflections from the CHANGE project
Improving how we use workshops when solving complex research problems: reflections from the CHANGE project
Organising workshops that successfully address complex research problems is a challenge, especially when the research invo...
A clinical chemical atlas of xenobiotic toxicity for the Sprague–Dawley rat
A clinical chemical atlas of xenobiotic toxicity for the Sprague–Dawley rat
The Consortium for Metabonomic Toxicology (COMET) studies was designed to model metabolic responses to organ- and mechanis...
A tiered next-generation risk assessment framework integrating toxicokinetics and NAM-based toxicodynamics: “proof of concept” case study using pyrethroids
A tiered next-generation risk assessment framework integrating toxicokinetics and NAM-based toxicodynamics: “proof of concept” case study using pyrethroids
New Approach Methodologies (NAMs) in Next-Generation Risk Assessment (NGRA), integrating toxicokinetics (TK) with toxicody...
A proposal of criteria to support the EU classification on endocrine disruption for the thyroid modality and their application to four data-rich case studies
A proposal of criteria to support the EU classification on endocrine disruption for the thyroid modality and their application to four data-rich case studies
Recently, the European Commission has implemented hazard categories to classify substances as endocrine disruptors for hum...
Advancing in vitro assessment of iodide uptake inhibition: integrating a novel biotransformation pretreatment step
Advancing in vitro assessment of iodide uptake inhibition: integrating a novel biotransformation pretreatment step
Thyroid hormones (TH) are essential for vertebrate development, growth, and metabolism. The increasing prevalence of anthr...
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