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Marine bacteria and fungi: the hidden treasure of oceans in the biodegradation of microplastics and hydrocarbons integrated with omics technologies
Marine bacteria and fungi: the hidden treasure of oceans in the biodegradation of microplastics and hydrocarbons integrated with omics technologies
Marine microorganisms play a crucial role in maintaining oceanic ecosystem stability by mediating essential biogeochemical...
Comparative in vitro study of structure related uptake of ten perfluoroalkyl substances by human and rat renal transporters
Comparative in vitro study of structure related uptake of ten perfluoroalkyl substances by human and rat renal transporters
Understanding the renal mechanisms underlying per- and polyfluoroalkyl substances (PFASs) elimination is critical to expla...
Developmental neurotoxicity of atrazine: decreased synaptic spine density and miRNA-driven GluN2A downregulation in primary hippocampal neurons
Developmental neurotoxicity of atrazine: decreased synaptic spine density and miRNA-driven GluN2A downregulation in primary hippocampal neurons
Atrazine (ATZ) is a triazine herbicide and a persistent environmental contaminant. Its use is associated with effects on t...
Involvement of lysosomal proteins in morphology-driven toxicity of (nano)fibers
Involvement of lysosomal proteins in morphology-driven toxicity of (nano)fibers
Fiber morphology (length > 5 μm; respirable diameter < 3 _...
Ancestry informative genetic variants associated with tobacco metabolic and detoxification capacity measured by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) among smokers
Ancestry informative genetic variants associated with tobacco metabolic and detoxification capacity measured by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) among smokers
Tobacco use remains the leading preventable cause of cancer mortality worldwide, with marked disparities in cancer inciden...
Chalcones as multitarget modulators in non-small cell lung cancer: mechanistic insights and therapeutic perspectives
Chalcones as multitarget modulators in non-small cell lung cancer: mechanistic insights and therapeutic perspectives
Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related mortality worldwide, and the search for nov...
Impact of low-frequency electromagnetic fields on DNA instability caused by environmentally and occupationally relevant chemicals in lymphocytes of donors with different demographic characteristics
Impact of low-frequency electromagnetic fields on DNA instability caused by environmentally and occupationally relevant chemicals in lymphocytes of donors with different demographic characteristics
Aim of this study was to find out if demographic factors (age and body weight) have an impact on the sensitivity of periph...
AhR activation triggers the synergistic genotoxicity between benzo[a]pyrene and aflatoxin B1 in metabolic-competent HepaRP cells
AhR activation triggers the synergistic genotoxicity between benzo[a]pyrene and aflatoxin B1 in metabolic-competent HepaRP cells
Human dietary exposure involves multiple contaminants, raising concerns about “cocktail” effects ignored by si...
Molecular characterization of the uterotrophic assay: temporal gene expression changes in uterus and pituitary gland following ethinylestradiol
Molecular characterization of the uterotrophic assay: temporal gene expression changes in uterus and pituitary gland following ethinylestradiol
The uterotrophic bioassay is a recognized tool for assessing estrogenic activities of chemicals, relying on estrogen-induc...
Revisiting cannabinoid receptor-2: a key regulator of hepatic steatosis, inflammatory cascades, and fibrotic progression
Revisiting cannabinoid receptor-2: a key regulator of hepatic steatosis, inflammatory cascades, and fibrotic progression
Liver diseases constitute a major global health challenge, affecting over 25% of the world’s population, with metabo...
Learning the assay, not the hazard: how computational toxicity models inherit the artifacts of their high-throughput training data
Learning the assay, not the hazard: how computational toxicity models inherit the artifacts of their high-throughput training data
High-throughput screening data have become the de facto ground truth for in silico toxicology. But a high-throughput ̶...
The aryl hydrocarbon receptor is downregulated in MASLD while its activation attenuates steatosis in human hepatocytes through an IGFBP1-associated pathway
The aryl hydrocarbon receptor is downregulated in MASLD while its activation attenuates steatosis in human hepatocytes through an IGFBP1-associated pathway
Metabolic dysfunction–associated steatotic liver disease (MASLD) represents a growing global health concern; however...
How structural variations in synthetic cannabinoids affect their metabolism: A pilot study on the in vivo metabolism of 8 synthetic cannabinoid receptor agonists
How structural variations in synthetic cannabinoids affect their metabolism: A pilot study on the in vivo metabolism of 8 synthetic cannabinoid receptor agonists
The structural diversity and continuous emergence of synthetic cannabinoid receptor agonists (SCRAs) pose an important cha...
Challenging the specificity of chlorzoxazone and 4-nitrophenol as marker substrates for CYP2E1 activity in Supersomes™
Challenging the specificity of chlorzoxazone and 4-nitrophenol as marker substrates for CYP2E1 activity in Supersomes™
Cytochrome P450 2E1 (CYP2E1) plays a pivotal role in the metabolism and detoxification of low molecular-weight xenobiotics...
Oxidative stress and inflammation in neurodegenerative disorders
Oxidative stress and inflammation in neurodegenerative disorders
The brain’s consumption of approximately 20% of the body’s oxygen contributes to oxidative stress, a significa...
Cardiosim-Tox: an interpretable multitask deep learning QSAR platform with multimodal feature fusion for predicting hERG, Cav1.2, and Nav1.5 blockade risk and potency
Cardiosim-Tox: an interpretable multitask deep learning QSAR platform with multimodal feature fusion for predicting hERG, Cav1.2, and Nav1.5 blockade risk and potency
Drug-induced cardiotoxicity, mainly driven by cardiac ion-channel blockade, remains a leading cause of drug attrition and ...
Toxic in vitro effects of flavoured-air inhalers containing essential oils in differentiated human nasal epithelial cells at air–liquid interface
Toxic in vitro effects of flavoured-air inhalers containing essential oils in differentiated human nasal epithelial cells at air–liquid interface
Flavoured-air inhalers containing essential oils are marketed as safe, natural alternatives to smoking and vaping, yet the...
Exploring the potential of liver microphysiological systems of varied configurations to model cholestatic chemical effects
Exploring the potential of liver microphysiological systems of varied configurations to model cholestatic chemical effects
Human in vitro liver tissue models have evolved to maintain hallmarks of hepatocellular function for extended periods with...
Scorpion venom as a molecular treasure: emerging bioactive compounds and translational therapeutic insights
Scorpion venom as a molecular treasure: emerging bioactive compounds and translational therapeutic insights
Scorpion venom contains a diverse array of bioactive compounds, including peptides, proteins, enzymes, and alkaloids, whic...
3,3'-Dichlorobiphenyl (PCB 11) alters the hepatic expression of cytochrome P450 enzymes in the liver of mouse dams exposed orally during pregnancy and lactation
3,3'-Dichlorobiphenyl (PCB 11) alters the hepatic expression of cytochrome P450 enzymes in the liver of mouse dams exposed orally during pregnancy and lactation
Healthy maternal metabolism is critical during pregnancy and lactation to support fetal development and protect against en...
Mechanism of liver fibrosis induced by life-long triclosan exposure in offspring rats: an adverse outcome pathway framework validated by in vivo and in vitro experiments
Mechanism of liver fibrosis induced by life-long triclosan exposure in offspring rats: an adverse outcome pathway framework validated by in vivo and in vitro experiments
Triclosan (TCS), a broad-spectrum lipophilic antiseptic, is frequently found in household and healthcare supplies. Its inc...
Cross-ancestry meta-analysis identifies a variant in the polycyclic aromatic hydrocarbons metabolism-related pathway contributing to colorectal cancer susceptibility
Cross-ancestry meta-analysis identifies a variant in the polycyclic aromatic hydrocarbons metabolism-related pathway contributing to colorectal cancer susceptibility
Unhealthy diets (e.g., higher red meat consumption) and tobacco exposure are major risk factors for colorectal cancer (CRC...
SARS-CoV-2 mRNA vaccines: unresolved mechanisms of myocardial damage
SARS-CoV-2 mRNA vaccines: unresolved mechanisms of myocardial damage
Myopericarditis requiring emergency care or hospitalization after COVID-19 mRNA vaccination occurs most frequently in adol...
Insights into the human metabolism and in silico receptor activity of gidazepam and desalkylgidazepam
Insights into the human metabolism and in silico receptor activity of gidazepam and desalkylgidazepam
Desalkylgidazepam, an active gidazepam metabolite, first appeared on the illicit drug market in 2022 and has been detected...
Correction: Effect of ‑acetyltransferase 2 genetic polymorphism on 4,4′‑methylenebis(2‑chloroaniline)‑induced genotoxicity and oxidative stress
Correction: Effect of ‑acetyltransferase 2 genetic polymorphism on 4,4′‑methylenebis(2‑chloroaniline)‑induced genotoxicity and oxidative stress
Cite this articleHabil, M.R., Salazar‑González, R.A., Doll, M.A. et al. Correction: Effect of N‑acetyltransferase 2 geneti...
Toxicological profiling of venoms from ten major Chinese snakes: a mass spectrometry-based proteomic and multiroute assessment
Toxicological profiling of venoms from ten major Chinese snakes: a mass spectrometry-based proteomic and multiroute assessment
Snake envenomation, a neglected tropical disease, presents complex and species-dependent systemic pathophysiology. Here, w...
Qualitative and quantitative in silico toxicity profiling of “angel dust”: phencyclidine (PCP) analogues as new psychoactive substances (3-HO-PCP, 3-MeO-PCP, 4-MeO-PCP, 3-HO-PCE, 3-MeO-PCE, 4-MeO-PCE)
Qualitative and quantitative in silico toxicity profiling of “angel dust”: phencyclidine (PCP) analogues as new psychoactive substances (3-HO-PCP, 3-MeO-PCP, 4-MeO-PCP, 3-HO-PCE, 3-MeO-PCE, 4-MeO-PCE)
Phencyclidine (PCP), historically known as “angel dust,” and its analogues (3-HO-PCP, 3-MeO-PCP, 4-MeO-PCP, 3-...
Projection-based molecular feature maps for CNN-driven nephrotoxicity prediction
Projection-based molecular feature maps for CNN-driven nephrotoxicity prediction
The development of reliable predictive models for nephrotoxic agents remains a critical challenge in drug development, giv...
Mechanism-based new approach methodologies for in vitro detection of chemical-induced liver steatosis
Mechanism-based new approach methodologies for in vitro detection of chemical-induced liver steatosis
Liver steatosis resulting from chemical exposure is a growing clinical concern, pointing to the need for early detection i...
Health impacts of micro- and nanoplastics: key influencing factors, limitations, and future perspectives
Health impacts of micro- and nanoplastics: key influencing factors, limitations, and future perspectives
Micro- and nanoplastics (MNPs) are emerging environmental threats, with increasing evidence of their profound ecotoxicolog...
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