Abdella MH et al (2024) Cytotoxic profiling of the marine gastropod (conus textile) venom extracts on human cancer cell lines unveiling its therapeutic side as anti-cancer therapeutic agents. Egypt J Aquat Biolo and Fish. https://doi.org/10.21608/ejabf.2024.346200
Ageitos L, Torres MDT, de la Fuente-Nunez C (2022) Biologically active peptides from venoms: applications in antibiotic resistance, cancer, and beyond. Int J Mol Sci. https://doi.org/10.3390/ijms232315437
Article PubMed PubMed Central Google Scholar
Akef HM (2018) Anticancer, antimicrobial, and analgesic activities of spider venoms. Toxicol Res. https://doi.org/10.1039/c8tx00022k
Alhakamy NA, Ahmed OAA, Fahmy UA, Md S (2021) Apamin-conjugated alendronate sodium nanocomplex for management of pancreatic cancer. Pharmaceuticals. https://doi.org/10.3390/ph14080729
Article PubMed PubMed Central Google Scholar
Amreen Nisa S, Vinu D, Krupakar P et al (2021) Jellyfish venom proteins and their pharmacological potentials: a review. Int J Biol Macromol 176:424–436. https://doi.org/10.1016/j.ijbiomac.2021.02.074
Article CAS PubMed Google Scholar
Arbiser JL, Kau T, Konar M et al (2007) Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis. Blood 109:560–565. https://doi.org/10.1182/blood-2006-06-029934
Article CAS PubMed PubMed Central Google Scholar
Badivi S, Kazemi S, Eskandarisani M et al (2024) Targeted delivery of bee venom to A549 lung cancer cells by PEGylate liposomal formulation: an apoptotic investigation. Sci Rep. https://doi.org/10.1038/s41598-024-68156-6
Article PubMed PubMed Central Google Scholar
Badr G, Garraud O, Daghestani M et al (2012) Human breast carcinoma cells are induced to apoptosis by samsum ant venom through an IGF-1-dependant pathway, PI3K/AKT and ERK signaling. Cell Immunol 273:10–16. https://doi.org/10.1016/j.cellimm.2011.12.003
Article CAS PubMed Google Scholar
Badr-Eldin SM, Aldawsari HM, Fahmy UA et al (2022) Optimized apamin-mediated nano-lipidic carrier potentially enhances the cytotoxicity of ellagic acid against human breast cancer cells. Int J Mol Sci. https://doi.org/10.3390/ijms23169440
Article PubMed PubMed Central Google Scholar
Chbel A, Delgado AS, Soukri A, El Khalfi B (2021) Marine biomolecules: a promising approach in therapy and biotechnology. Eur J Biolog Res. https://doi.org/10.5281/ZENODO.4384158
Chbel A, Rodriguez-Castro J, Quinteiro J et al (2022) Isolation molecular identification and antibacterial potential of marine bacteria from deep atlantic ocean of morocco. Avicen J Med Biotechnol. https://doi.org/10.18502/ajmb.v14i3.9827
Chbel A, Lafnoune A, Nait Irahal I, Bourhim N (2024a) Macromolecules from mushrooms, venoms, microorganisms, and plants for diabetes treatment-Progress or setback? Biochimie S0300–9084(24):00163–00169. https://doi.org/10.1016/j.biochi.2024.07.004
Chbel A, Rey-Méndez M, L. Barja J, et al (2024b) Characterization of novel marine bacteria isolated from deep Atlantic Ocean in Morocco as a source of natural bioactive compounds to control infections in aquaculture. Biocataly Agricult Biotechnol. https://doi.org/10.1016/j.bcab.2024.103350
da Silva AMB, Silva-Gonçalves LC, Oliveira FA, Arcisio-Miranda M (2018) Pro-necrotic activity of cationic mastoparan peptides in human glioblastoma multiforme cells via membranolytic action. Mol Neurobiol 55:5490–5504. https://doi.org/10.1007/s12035-017-0782-1
Article CAS PubMed Google Scholar
de Azevedo RA, Figueiredo CR, Ferreira AK et al (2015) Mastoparan induces apoptosis in B16F10-Nex2 melanoma cells via the intrinsic mitochondrial pathway and displays antitumor activity in vivo. Peptides 68:113–119. https://doi.org/10.1016/j.peptides.2014.09.024
Article CAS PubMed Google Scholar
de Bordon KCF, Cologna CT, Fornari-Baldo EC et al (2020) From animal poisons and venoms to medicines: achievements challenges and perspectives in drug discovery. Front Pharmacol. https://doi.org/10.3389/fphar.2020.01132
Article PubMed PubMed Central Google Scholar
Debela DT, Muzazu SG, Heraro KD et al (2021) New approaches and procedures for cancer treatment: current perspectives. Open Med 9:20503121211034370. https://doi.org/10.1177/20503121211034366
Desales-Salazar E, Khusro A, Cipriano-Salazar M et al (2020a) Scorpion venoms and associated toxins as anticancer agents: update on their application and mechanism of action. J Appl Toxicol 40:1310–1324. https://doi.org/10.1002/jat.3976
Article CAS PubMed Google Scholar
Desales-Salazar E, Khusro A, Cipriano-Salazar M et al (2020b) Scorpion venoms and associated toxins as anticancer agents: update on their application and mechanism of action. J Appl Toxicol 40:1310–1324. https://doi.org/10.1002/jat.3976
Article CAS PubMed Google Scholar
Díaz-García A, Varela D (2020) Voltage-gated K+/Na+ channels and scorpion venom toxins in cancer. Front Pharmacol 11:913. https://doi.org/10.3389/fphar.2020.00913
Article CAS PubMed PubMed Central Google Scholar
dos Santos Cabrera MP, Arcisio-Miranda M, Gorjão R et al (2012) Influence of the bilayer composition on the binding and membrane disrupting effect of Polybia-MP1, an antimicrobial mastoparan peptide with leukemic T-lymphocyte cell selectivity. Biochemistry 51:4898–4908. https://doi.org/10.1021/bi201608d
Article CAS PubMed Google Scholar
Dueñas-Cuellar RA, Santana CJC, Magalhães ACM et al (2020) Scorpion toxins and ion channels: potential applications in cancer therapy. Toxins 12:326. https://doi.org/10.3390/toxins12050326
Article CAS PubMed PubMed Central Google Scholar
Duffy C, Sorolla A, Wang E et al (2020) Honeybee venom and melittin suppress growth factor receptor activation in HER2-enriched and triple-negative breast cancer. Precis Onc. https://doi.org/10.1038/s41698-020-00129-0
El-Qassas J, Abd El-Atti M, El-Badri N (2024) Harnessing the potency of scorpion venom-derived proteins: applications in cancer therapy. Bioresour Bioprocess 11:93. https://doi.org/10.1186/s40643-024-00805-0
Article PubMed PubMed Central Google Scholar
Erkoc P, von Reumont BM, Lüddecke T et al (2022) The pharmacological potential of novel melittin variants from the honeybee and solitary bees against inflammation and cancer. Toxins 14:818. https://doi.org/10.3390/toxins14120818
Article CAS PubMed PubMed Central Google Scholar
Ertilav K, Nazıroğlu M (2023) Honey bee venom melittin increases the oxidant activity of cisplatin and kills human glioblastoma cells by stimulating the TRPM2 channel. Toxicon 222:106993. https://doi.org/10.1016/j.toxicon.2022.106993
Article CAS PubMed Google Scholar
Gao L, Feng W, Shan B-E, Zhu B-C (2005) Inhibitory effect of the venom of spider Macrothele raveni on proliferation of human hepatocellular carcinoma cell line BEL-7402 and its mechanism. Ai Zheng 24:812–816
Gerges MM, Abdel-Rahman MA, Rahmy TR et al (2024) Cytotoxic activity and mechanism of action of Smp43 scorpion peptide against colorectal cancer cell line HCT-116. Tox Rev. https://doi.org/10.1080/15569543.2024.2344471
Giribaldi J, Smith JJ, Schroeder CI (2021) Recent developments in animal venom peptide nanotherapeutics with improved selectivity for cancer cells. Biotechnol Adv 50:107769. https://doi.org/10.1016/j.biotechadv.2021.107769
Article CAS PubMed Google Scholar
Guo R, Liu J, Chai J et al (2022) Scorpion peptide Smp24 exhibits a potent antitumor effect on human lung cancer cells by damaging the membrane and cytoskeleton in vivo and in vitro. Toxins 14:438. https://doi.org/10.3390/toxins14070438
Article CAS PubMed PubMed Central Google Scholar
Guo R, Guo G, Wang A et al (2023) Spider-venom peptides: structure, bioactivity, strategy, and research applications. Molecules 29:35. https://doi.o
Comments (0)