Padmanabhan A, Lynch CJ, Schaer M, Menon V. The default mode network in autism. Biol Psychiatry Cogn Neurosci Neuroimaging. 2017;2(6):476–86.

PubMed  PubMed Central  Google Scholar 

Nair A, Jolliffe M, Lograsso YSS, Bearden CE. A review of default mode network connectivity and its association with social cognition in adolescents with autism spectrum disorder and Early-Onset psychosis. Front Psychiatry. 2020;11:614.

PubMed  PubMed Central  Google Scholar 

Harikumar A, Evans DW, Dougherty CC, Carpenter KLH, Michael AM. A review of the default mode network in autism spectrum disorders and attention deficit hyperactivity disorder. Brain Connect. 2021;11(4):253–63.

PubMed  PubMed Central  Google Scholar 

Hull JV, Dokovna LB, Jacokes ZJ, Torgerson CM, Irimia A, Van Horn JD. Resting-State functional connectivity in autism spectrum disorders: A review. Front Psychiatry. 2016;7:205.

PubMed  Google Scholar 

Tyszka JM, Kennedy DP, Paul LK, Adolphs R. Largely typical patterns of resting-state functional connectivity in high-functioning adults with autism. Cereb Cortex. 2014;24(7):1894–905.

PubMed  Google Scholar 

He Y, Byrge L, Kennedy DP. Nonreplication of functional connectivity differences in autism spectrum disorder across multiple sites and denoising strategies. Hum Brain Mapp. 2020;41(5):1334–50.

PubMed  PubMed Central  Google Scholar 

Smyser CD, Snyder AZ, Neil JJ. Functional connectivity MRI in infants: exploration of the functional organization of the developing brain. NeuroImage. 2011;56(3):1437–52.

PubMed  Google Scholar 

Gao W, Gilmore JH, Shen D, Smith JK, Zhu H, Lin W. The synchronization within and interaction between the default and dorsal attention networks in early infancy. Cereb Cortex. 2013;23(3):594–603.

PubMed  Google Scholar 

Pruett JR Jr., Kandala S, Hoertel S, Snyder AZ, Elison JT, Nishino T, et al. Accurate age classification of 6 and 12 month-old infants based on resting-state functional connectivity magnetic resonance imaging data. Dev Cogn Neurosci. 2015;12:123–33.

PubMed  PubMed Central  Google Scholar 

Gao W, Alcauter S, Smith JK, Gilmore JH, Lin W. Development of human brain cortical network architecture during infancy. Brain Struct Funct. 2015;220(2):1173–86.

PubMed  Google Scholar 

Gao W, Lin W, Grewen K, Gilmore JH. Functional Connectivity of the Infant Human Brain: Plastic and Modifiable. Neuroscientist. 2017;23(2):169–84.

Cao M, Huang H, He Y. Developmental connectomics from infancy through early childhood. Trends Neurosci. 2017;40(8):494–506.

CAS  PubMed  PubMed Central  Google Scholar 

Zhang H, Shen D, Lin W. Resting-state functional MRI studies on infant brains: A decade of gap-filling efforts. NeuroImage. 2019;185:664–84.

PubMed  Google Scholar 

Ozonoff S, Iosif AM, Baguio F, Cook IC, Hill MM, Hutman T, et al. A prospective study of the emergence of early behavioral signs of autism. J Am Acad Child Adolesc Psychiatry. 2010;49(3):256–66.

PubMed  PubMed Central  Google Scholar 

Eggebrecht AT, Elison JT, Feczko E, Todorov A, Wolff JJ, Kandala S, et al. Joint attention and brain functional connectivity in infants and toddlers. Cereb Cortex. 2017;27(3):1709–20.

PubMed  PubMed Central  Google Scholar 

Marrus N, Eggebrecht AT, Todorov A, Elison JT, Wolff JJ, Cole L, et al. Walking, gross motor development, and brain functional connectivity in infants and toddlers. Cereb Cortex. 2018;28(2):750–63.

PubMed  Google Scholar 

McKinnon CJ, Eggebrecht AT, Todorov A, Wolff JJ, Elison JT, Adams CM, et al. Restricted and repetitive behavior and brain functional connectivity in infants at risk for developing autism spectrum disorder. Biol Psychiatry Cogn Neurosci Neuroimaging. 2019;4(1):50–61.

PubMed  Google Scholar 

Ciarrusta J, Dimitrova R, Batalle D, O’Muircheartaigh J, Cordero-Grande L, Price A, et al. Emerging functional connectivity differences in newborn infants vulnerable to autism spectrum disorders. Transl Psychiatry. 2020;10(1):131.

PubMed  PubMed Central  Google Scholar 

Chen B, Linke A, Olson L, Ibarra C, Reynolds S, Muller RA et al. Greater functional connectivity between sensory networks is related to symptom severity in toddlers with autism spectrum disorder. J Child Psychol Psychiatry. 2021;62(2):160–70.

Liu J, Okada NJ, Cummings KK, Jung J, Patterson G, Bookheimer SY, et al. Emerging atypicalities in functional connectivity of language-related networks in young infants at high Familial risk for ASD. Dev Cogn Neurosci. 2020;45:100814.

PubMed  PubMed Central  Google Scholar 

Hawks ZT, Nishino A, Talovic T, Marrus M, Nebel N, Davis M, Marek S, Seitzman S, Eggebrecht B, Elison A, Dager J, Mosconi S, Tychsen M, Snyder L, Botteron A, Estes K, Evans A, Gerig A, Hazlett G, McKinstry H, Pandey R, Schultz J, Styner R, Wolff M, Zwaigenbaum J, Piven L, Pruett J. JR, Jr.; for the IBIS network. A prospective evaluation of infant cerebellar-cerebral functional connectivity in relation to behavioral development in autism. Biological Psychiatry: Global Open Science; 2021.

Google Scholar 

Nair A, Jalal R, Liu J, Tsang T, McDonald NM, Jackson L, et al. Altered thalamocortical connectivity in 6-Week-Old infants at high Familial risk for autism spectrum disorder. Cereb Cortex. 2021;31(9):4191–205.

PubMed  PubMed Central  Google Scholar 

Girault JB, Donovan K, Hawks Z, Talovic M, Forsen E, Elison JT et al. Infant visual brain development and inherited genetic liability in autism. Am J Psychiatry. 2022:appiajp21101002.

Wagner L, Banchik M, Okada NJ, McDonald N, Jeste SS, Bookheimer SY, et al. Associations between thalamocortical functional connectivity and sensory over-responsivity in infants at high likelihood for ASD. Cereb Cortex. 2023;33(12):8075–86.

PubMed  PubMed Central  Google Scholar 

Xiao Y, Wen TH, Kupis L, Eyler LT, Taluja V, Troxel J, et al. Atypical functional connectivity of Temporal cortex with precuneus and visual regions May be an early-age signature of ASD. Mol Autism. 2023;14(1):11.

PubMed  PubMed Central  Google Scholar 

Emerson RW, Adams CM, Nishino T, Hazlett HC, Wolff JJ, Zwaigenbaum L et al. Functional neuroimaging in high-risk 6-month-old infants predicts a diagnosis of autism at 24 months of age. Sci Transl Med. 2017;9(393):eaag2882.

Hazlett HC, Gu H, Munsell BC, Kim SH, Styner M, Wolff JJ, et al. Early brain development in infants at high risk for autism spectrum disorder. Nature. 2017;542(7641):348–51.

CAS  PubMed  PubMed Central  Google Scholar 

Vivanti G, Dissanayake C, Team VA. Outcome for children receiving the early start Denver model before and after 48 months. J Autism Dev Disord. 2016;46(7):2441–9.

PubMed  Google Scholar 

Grzadzinski R, Amso D, Landa R, Watson L, Guralnick M, Zwaigenbaum L, et al. Pre-symptomatic intervention for autism spectrum disorder (ASD): defining a research agenda. J Neurodev Disord. 2021;13(1):49.

PubMed  PubMed Central  Google Scholar 

Paul SM, Mytelka DS, Dunwiddie CT, Persinger CC, Munos BH, Lindborg SR, et al. How to improve R&D productivity: the pharmaceutical industry’s grand challenge. Nat Rev Drug Discov. 2010;9(3):203–14.

CAS  PubMed  Google Scholar 

Owens PK, Raddad E, Miller JW, Stille JR, Olovich KG, Smith NV, et al. A decade of innovation in pharmaceutical R&D: the chorus model. Nat Rev Drug Discov. 2015;14(1):17–28.

CAS  PubMed  Google Scholar 

Maenner MJ, Warren Z, Williams AR, Amoakohene E, Bakian AV, Bilder DA, et al. Prevalence and characteristics of autism spectrum disorder among children aged 8 Years - autism and developmental disabilities monitoring network, 11 sites, united States, 2020. MMWR Surveill Summ. 2023;72(2):1–14.

PubMed  PubMed Central  Google Scholar 

Jones EJH, Glia T, Bedford R, Charman T, Johnson MH. Developmental pathways to autism: A review of prospective studies of infants at risk. Neurosci Biobehav Rev. 2014;39:1–33.

Ozonoff S, Young GS, Carter A, Messinger D, Yirmiya N, Zwaigenbaum L, et al. Recurrence risk for autism spectrum disorders: a baby siblings research consortium study. Pediatrics. 2011;128(3):e488–95.

PubMed  PubMed Central  Google Scholar 

Constantino JN, Todd RD. Autistic traits in the general population: a twin study. Arch Gen Psychiatry. 2003;60(5):524–30.

PubMed  Google Scholar 

Messinger D, Young GS, Ozonoff S, Dobkins K, Carter A, Zwaigenbaum L, et al. Beyond autism: a baby siblings research consortium study of high-risk children at three years of age. J Am Acad Child Adolesc Psychiatry. 2013;52(3):300–e81.

PubMed  PubMed Central  Google Scholar 

Estes A, Zwaigenbaum L, Gu H, St John T, Paterson S, Elison JT, et al. Behavioral, cognitive, and adaptive development in infants with autism spectrum disorder in the first 2 years of life. J Neurodev Disord. 2015;7(1):24.

PubMed  PubMed Central  Google Scholar 

Charman T, Young GS, Brian J, Carter A, Carver LJ, Chawarska K et al. Non-ASD outcomes at 36 months in siblings at Familial risk for autism spectrum disorder (ASD): A baby siblings research consortium (BSRC) study. Autism Res. 2017;10(1):169–78.

Lee PH, Feng YA, Smoller JW. Pleiotropy and Cross-Disorder genetics among psychiatric disorders. Biol Psychiatry. 2021;89(1):20–31.

CAS  PubMed  Google Scholar 

Watanabe K, Stringer S, Frei O, Umicevic Mirkov M, de Leeuw C, Polderman TJC, et al. A global overview of Pleiotropy and genetic architecture in complex traits. Nat Genet. 2019;51(9):1339–48.

CAS  PubMed  Google Scholar 

Gandal MJ, Haney JR, Parikshak NN, Leppa V, Ramaswami G, Hartl C, et al. Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap. Science. 2018;359(6376):693–7.

CAS  PubMed  PubMed Central  Google Scholar 

Das S, Glatard T, MacIntyre LC, Madjar C, Rogers C, Rousseau ME, et al. The MNI data-sharing and processing ecosystem. NeuroImage. 2016;124(Pt B):1188–95.

PubMed  Google Scholar 

Gotham K, Pickles A, Lord C. Standardizing ADOS scores for a measure of severity in autism spectrum disorders. J Autism Dev Disord. 2009;39(5):693–705.

PubMed