Abdik E, Çakır T (2024) Transcriptome-based biomarker prediction for Parkinson’s disease using genome-scale metabolic modeling. Sci Rep 14:585. https://doi.org/10.1038/s41598-023-51034-y
Article CAS PubMed PubMed Central Google Scholar
Alieva AK et al (2017) Transcriptome profile changes in mice with MPTP-induced early stages of Parkinson’s disease. Mol Neurobiol 54:6775–6784. https://doi.org/10.1007/s12035-016-0190-y
Article CAS PubMed Google Scholar
Alieva AK et al (2018) Whole-transcriptome analysis of mouse models with MPTP-induced early stages of Parkinson’s disease reveals stage-specific response of transcriptome and a possible role of myelin-linked genes in neurodegeneration. Mol Neurobiol 55:7229–7241. https://doi.org/10.1007/s12035-018-0907-1
Article CAS PubMed Google Scholar
Bedard K, Krause K-H (2007) The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev 87:245–313. https://doi.org/10.1152/physrev.00044.2005
Article CAS PubMed Google Scholar
Bido S et al (2021) Microglia-specific overexpression of α-synuclein leads to severe dopaminergic neurodegeneration by phagocytic exhaustion and oxidative toxicity. Nat Commun 12:6237. https://doi.org/10.1038/s41467-021-26519-x
Article CAS PubMed PubMed Central Google Scholar
Chin MH et al (2008) Mitochondrial dysfunction, oxidative stress, and apoptosis revealed by proteomic and transcriptomic analyses of the striata in two mouse models of Parkinson’s disease. J Proteome Res 7:666–677. https://doi.org/10.1021/pr070546l
Article CAS PubMed PubMed Central Google Scholar
Durafourt BA et al (2012) Comparison of polarization properties of human adult microglia and blood-derived macrophages. Glia 60:717–727. https://doi.org/10.1002/glia.22298
George S et al (2019) Microglia affect α-synuclein cell-to-cell transfer in a mouse model of Parkinson’s disease. Mol Neurodegen 14:34. https://doi.org/10.1186/s13024-019-0335-3
Harms AS et al (2013) MHCII is required for α-synuclein-induced activation of microglia, CD4 T cell proliferation, and dopaminergic neurodegeneration. The J Neurosci 33:9592–9600. https://doi.org/10.1523/jneurosci.5610-12.2013
Article CAS PubMed Google Scholar
Hendrickx DM et al (2021) A new synuclein-transgenic mouse model for early Parkinson’s reveals molecular features of preclinical disease. Mol Neurobiol 58:576–602. https://doi.org/10.1007/s12035-020-02085-z
Article CAS PubMed Google Scholar
Hirsch EC, Vyas S, Hunot S (2012) Neuroinflammation in Parkinson’s disease. Parkinsonism Relat Disord 18:S210-212. https://doi.org/10.1016/s1353-8020(11)70065-7
Huang Q et al (2023) Cell type- and region-specific translatomes in an MPTP mouse model of Parkinson’s disease. Neurobiol Dis 180:106105. https://doi.org/10.1016/j.nbd.2023.106105
Article CAS PubMed Google Scholar
Idova GV, Alperina EL, Zhanaeva SY (2023) Neuroinflammation and immune dysfunction in the mechanisms of development of Parkinson’s disease. Neurosci Behav Physiol 53:1534–1550. https://doi.org/10.1007/s11055-023-01549-8
Isik S, Yeman Kiyak B, Akbayir R, Seyhali R, Arpaci T (2023) Microglia mediated neuroinflammation in Parkinson’s disease. Cells 12(7):1012
CAS PubMed PubMed Central Google Scholar
Jiang P et al (2019) Parkinson’s disease is associated with dysregulations of a dopamine-modulated gene network relevant to sleep and affective neurobehaviors in the striatum. Sci Rep 9:4808. https://doi.org/10.1038/s41598-019-41248-4
Article CAS PubMed PubMed Central Google Scholar
Kolacheva A, Pavlova E, Bannikova A, Bogdanov V, Ugrumov M (2024) Initial molecular mechanisms of the pathogenesis of Parkinson’s disease in a mouse neurotoxic model of the earliest preclinical stage of this disease. Int J Mol Sci. https://doi.org/10.3390/ijms25021354
Article PubMed PubMed Central Google Scholar
Kouli A, Horne CB, Williams-Gray CH (2019) Toll-like receptors and their therapeutic potential in Parkinson’s disease and α-synucleinopathies. Brain Behav Immun 81:41–51. https://doi.org/10.1016/j.bbi.2019.06.042
Article CAS PubMed Google Scholar
Kurvits L et al (2021) Transcriptomic profiles in Parkinson’s disease. Exp Biol Med (Maywood) 246:584–595. https://doi.org/10.1177/1535370220967325
Article CAS PubMed Google Scholar
Kurz A et al (2010) A53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice. PLoS One 5:e11464. https://doi.org/10.1371/journal.pone.0011464
Article CAS PubMed PubMed Central Google Scholar
Kurz A et al (2010) Alpha-synuclein deficiency affects brain Foxp1 expression and ultrasonic vocalization. Neuroscience 166:785–795. https://doi.org/10.1016/j.neuroscience.2009.12.054
Article CAS PubMed Google Scholar
Lema Tomé CM et al (2023) Inflammation and α-synuclein’s prion-like behavior in Parkinson’s disease—is there a link? Mol Neurobiol 47:561–574. https://doi.org/10.1007/s12035-012-8267-8
Liu TW, Chen CM, Chang KH (2022) Biomarker of neuroinflammation in Parkinson’s disease. Int J Mol Sci. https://doi.org/10.3390/ijms23084148
Article PubMed PubMed Central Google Scholar
Lv QK et al (2023) Role of α-synuclein in microglia: autophagy and phagocytosis balance neuroinflammation in Parkinson’s disease. Inflamm Res 72:443–462. https://doi.org/10.1007/s00011-022-01676-x
Article CAS PubMed Google Scholar
Lyu Y et al (2021) Transcriptome profiling of five brain regions in a 6-hydroxydopamine rat model of Parkinson’s disease. CNS Neurosci Therapeutics 27:1289–1299. https://doi.org/10.1111/cns.13702
Oh SJ et al (2020) Evaluation of the neuroprotective effect of microglial depletion by CSF-1R inhibition in a Parkinson’s animal model. Mol Imaging Biol 22:1031–1042. https://doi.org/10.1007/s11307-020-01485-w
Article CAS PubMed Google Scholar
Orr CF, Rowe DB, Mizuno Y, Mori H, Halliday GM (2005) A possible role for humoral immunity in the pathogenesis of Parkinson’s disease. Brain 128:2665–2674. https://doi.org/10.1093/brain/awh625
Park YH et al (2020) Dysregulated Fc gamma receptor-mediated phagocytosis pathway in Alzheimer’s disease: network-based gene expression analysis. Neurobiol Aging 88:24–32. https://doi.org/10.1016/j.neurobiolaging.2019.12.001
Parnetti L et al (2013) Cerebrospinal fluid biomarkers in Parkinson disease. Nat Rev Neurol 9:131–140. https://doi.org/10.1038/nrneurol.2013.10
Article CAS PubMed Google Scholar
Poewe W et al (2017) Parkinson disease. Nat Rev Dis Primers 3:17013. https://doi.org/10.1038/nrdp.2017.13
Reynolds AD et al (2008) Nitrated alpha-synuclein-activated microglial profiling for Parkinson’s disease. J Neurochem 104:1504–1525. https://doi.org/10.1111/j.1471-4159.2007.05087.x
Comments (0)