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Expanding the Clinical Spectrum of SCN8A-Related Epileptic Encephalopathy: Additional Auditory Impairment, Atypical MRI Abnormalities and Putative Mitochondrial Involvement
Expanding the Clinical Spectrum of SCN8A-Related Epileptic Encephalopathy: Additional Auditory Impairment, Atypical MRI Abnormalities and Putative Mitochondrial Involvement
High expression of the voltage-gated sodium channel NaV1.6 is essential for regulating neuronal excitability in both the c...
MC-350013 and Corylin Emerge as Promising Neuroprotective Agents through Dual Targeting of xCT and GLT-1
MC-350013 and Corylin Emerge as Promising Neuroprotective Agents through Dual Targeting of xCT and GLT-1
Studies have demonstrated the impact of alterations of glutamate homeostasis, involving particularly, its excitotoxicity e...
The Protective Role of Aquaporin 4 (AQP4) in Temporal Lobe Epilepsy: Yes or No?
The Protective Role of Aquaporin 4 (AQP4) in Temporal Lobe Epilepsy: Yes or No?
Temporal lobe epilepsy (TLE) is the most common type of focal epilepsy in adults that resists the conventional anti-seizur...
Autism Spectrum Disorders and Purinergic Signaling: A Systematic Review of Emerging Insights from Preclinical Studies
Autism Spectrum Disorders and Purinergic Signaling: A Systematic Review of Emerging Insights from Preclinical Studies
Autism Spectrum Disorders (ASD), are a group of complex neurodevelopmental conditions characterized by deficits in social ...
Chrysin Ameliorates Valproic Acid Induced Autism Spectrum Behavioral Phenotypes Through Corticohippocampal Histone Deacetylase and Translational Modulation of SHANK3 Expression in Juvenile Rats
Chrysin Ameliorates Valproic Acid Induced Autism Spectrum Behavioral Phenotypes Through Corticohippocampal Histone Deacetylase and Translational Modulation of SHANK3 Expression in Juvenile Rats
Autism spectrum disorder (ASD) is a neurodevelopmental disorder marked by repetitive behaviors, social deficits, and comor...
Pro-inflammatory Immune Dysregulation and Genetic Susceptibility in Iraqi Children with Autism: a Tetra-Primer ARMS-PCR Investigation of Interleukin Polymorphisms
Pro-inflammatory Immune Dysregulation and Genetic Susceptibility in Iraqi Children with Autism: a Tetra-Primer ARMS-PCR Investigation of Interleukin Polymorphisms
Autism Spectrum Disorder (ASD) is associated with multiple co-occurring conditions. Research has linked ASD with immune dy...
The Expression Patterns of Reference Genes in the Brains of Male Rats Subjected to CUMS-induced Depressive-like Behavior Strongly Depends on both the Age and the Specific Brain Region
The Expression Patterns of Reference Genes in the Brains of Male Rats Subjected to CUMS-induced Depressive-like Behavior Strongly Depends on both the Age and the Specific Brain Region
The objective of this investigation was to identify the most suitable candidates for RT-qPCR analysis. The study focused o...
Higher Serum Levels of Propionylcarnitine and Methionine are Associated with Reduced Cortical Amyloid Burden in Alzheimer’s Disease
Higher Serum Levels of Propionylcarnitine and Methionine are Associated with Reduced Cortical Amyloid Burden in Alzheimer’s Disease
Altered systemic metabolism contributes to Alzheimer’s disease (AD) pathology, yet the links between specific metabo...
Association of Statin use with Parkinson’s Disease Progression in a Prospective Cohort Study and Multi-omics Analyses
Association of Statin use with Parkinson’s Disease Progression in a Prospective Cohort Study and Multi-omics Analyses
While more than 30% of patients with Parkinson’s disease (PD) are prescribed statins, the impact of statin use on th...
Cutaneous α-Synuclein Pathology as a Differential Marker: A Histological and Statistical Comparison across Neurodegenerative Disease Groups
Cutaneous α-Synuclein Pathology as a Differential Marker: A Histological and Statistical Comparison across Neurodegenerative Disease Groups
There is an urgent need for early and accurate biomarkers of neurodegenerative disorders. Due to the high innervation and ...
Klotho Function in Neurogenesis and Oligodendrogenesis: A Mini-Review Update
Klotho Function in Neurogenesis and Oligodendrogenesis: A Mini-Review Update
Klotho is an anti-aging protein with multiple functions in maintaining homeostasis within the central nervous system (CNS)...
Protein Acylation Modifications in Sleep Disorders: Mechanisms and Therapeutic Potential
Protein Acylation Modifications in Sleep Disorders: Mechanisms and Therapeutic Potential
Protein acylation represents a class of metabolism-dependent post-translational modifications that are increasingly recogn...
Cognitive and Motor Dysfunction in STXBP1 R406H Mice
Cognitive and Motor Dysfunction in STXBP1 R406H Mice
The STXBP1 protein critically regulates synaptic vesicle fusion and neurotransmitter release, with its mutations implicate...
Lower Plasma Serotonin is Associated with Higher Amyloid Burden, Hippocampal Atrophy, and Cognitive decline in Alzheimer’s Disease: A 24-Month Longitudinal Study
Lower Plasma Serotonin is Associated with Higher Amyloid Burden, Hippocampal Atrophy, and Cognitive decline in Alzheimer’s Disease: A 24-Month Longitudinal Study
This study investigated longitudinal plasma serotonin dynamics across the Alzheimer’s disease (AD) continuum (cognit...
Targeting the Gut-Brain-Ferroptosis Axis: Molecular Mechanisms and Therapeutic Potential in Alzheimer’s Disease and Epilepsy
Targeting the Gut-Brain-Ferroptosis Axis: Molecular Mechanisms and Therapeutic Potential in Alzheimer’s Disease and Epilepsy
Alzheimer’s disease (AD) and epilepsy share underlying mechanisms of oxidative stress and neuroinflammation, yet eff...
Value of lncRNA LINC00641 as a Potential Biomarker for Diagnosis of Alzheimer’s Disease and Elucidation of its Underlying Molecular Mechanism
Value of lncRNA LINC00641 as a Potential Biomarker for Diagnosis of Alzheimer’s Disease and Elucidation of its Underlying Molecular Mechanism
Alzheimer’s disease (AD) is a neurodegenerative disease with progressive cognitive impairment as the main clinical m...
Network-Based Prioritization of Network-Peripheral Gene Modules in Autism Spectrum Disorder Using Integrative Transcriptomic and Proteomic Data
Network-Based Prioritization of Network-Peripheral Gene Modules in Autism Spectrum Disorder Using Integrative Transcriptomic and Proteomic Data
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition with complex genetic and molecular architec...
Chronic High-Carbohydrate And High-Fat Diet-Induced Metabolic Syndrome Leads To Adrenal Dysfunction, Altered Dendritic Morphology In Limbic Regions, And Anxiety-Like Behaviors In Male Rats
Chronic High-Carbohydrate And High-Fat Diet-Induced Metabolic Syndrome Leads To Adrenal Dysfunction, Altered Dendritic Morphology In Limbic Regions, And Anxiety-Like Behaviors In Male Rats
Metabolic syndrome (MS) represents a major global health problem affecting a large proportion of the population. The impro...
TASP1-Related Suleiman–El-Hattab Syndrome: The First Genetically Confirmed Case in Iran Accompanied by a Comprehensive Literature Review
TASP1-Related Suleiman–El-Hattab Syndrome: The First Genetically Confirmed Case in Iran Accompanied by a Comprehensive Literature Review
Suleiman–El-Hattab syndrome (SULEHS; OMIM #618674) is an ultra-rare autosomal recessive multisystem neurodevelopment...
Single Nucleotide Polymorphisms in Stroke: Evidence Across Susceptibility, Prognosis, and Recurrence; A Systematic Review
Single Nucleotide Polymorphisms in Stroke: Evidence Across Susceptibility, Prognosis, and Recurrence; A Systematic Review
Stroke is a leading cause of global morbidity and mortality. Genetic variation, particularly single nucleotide polymorphis...
Non-targeted and Targeted Metabolomics Techniques Reveal Striatal Metabolome Characteristics in the Ketamine-Induced Conditioned Place Preference Mice Model
Non-targeted and Targeted Metabolomics Techniques Reveal Striatal Metabolome Characteristics in the Ketamine-Induced Conditioned Place Preference Mice Model
Ketamine is a synthesized anesthetic drug that was used extensively as a surgical anesthetic in the 1960s. Currently, keta...
Methylomic Changes in MTHFR Promoter Region, along with the Heterozygous C677T Polymorphism, Contribute to the Risk of Thrombotic Stroke
Methylomic Changes in MTHFR Promoter Region, along with the Heterozygous C677T Polymorphism, Contribute to the Risk of Thrombotic Stroke
Stroke is the second leading cause of death globally and a major contributor to disability. Developing countries report th...
ZDHHC13 Reduces the Risk of Ischemic Stroke by Regulating Metabolites
ZDHHC13 Reduces the Risk of Ischemic Stroke by Regulating Metabolites
Recent studies have shown that palmitoylation is involved in ischemic stroke(IS). However, the role of palmitoylation in I...
Investigating Oxidative Stress and Impaired DNA Repair Capacity as Diagnostic Biomarkers in Autism Spectrum Disorder
Investigating Oxidative Stress and Impaired DNA Repair Capacity as Diagnostic Biomarkers in Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by early-onset social communication deficits...
Transcriptomic Analysis of Immune-Related Genes in the Striatum of Parkinson’s Disease Brain Across Mouse Strains
Transcriptomic Analysis of Immune-Related Genes in the Striatum of Parkinson’s Disease Brain Across Mouse Strains
This study conducted a transcriptomic analysis to identify differentially expressed genes involved in immune-related pathw...
Gamma Oscillation Disruption Induced By Microglial Activation Contributes to Perioperative Neurocognitive Disorders in Aged Mice
Gamma Oscillation Disruption Induced By Microglial Activation Contributes to Perioperative Neurocognitive Disorders in Aged Mice
Perioperative neurocognitive disorder (PND) is a prevalent postoperative complication of the central nervous system (CNS) ...
Demographic, Clinical, and Molecular Determinants of Quality of Life and Oxidative Stress in Multiple Sclerosis: A Cross-Sectional Study from Sulaymaniyah, Iraq
Demographic, Clinical, and Molecular Determinants of Quality of Life and Oxidative Stress in Multiple Sclerosis: A Cross-Sectional Study from Sulaymaniyah, Iraq
This is the first study in Iraq to integrate socioeconomic, genetic, and oxidative stress markers in MS patients, revealin...
ZDHHC4 Influences Obsessive–Compulsive Disorder Risk Through Imaging-Derived Phenotypes: A Mendelian Randomization Study
ZDHHC4 Influences Obsessive–Compulsive Disorder Risk Through Imaging-Derived Phenotypes: A Mendelian Randomization Study
Obsessive–compulsive disorder (OCD) affects 1–3% of the global population and ranks among the top ten most dis...
Aggregation-Prone Pathogenic SOD1 Variants in Amyotrophic Lateral Sclerosis: Insights from Computational Genomics and Evolutionary Conservation
Aggregation-Prone Pathogenic SOD1 Variants in Amyotrophic Lateral Sclerosis: Insights from Computational Genomics and Evolutionary Conservation
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive motor neuron degene...
Finerenone Modulates PANoptosis to Improve Immune Microenvironment in Diabetic Nephropathy: A Machine Learning–Based Mechanistic Analysis
Finerenone Modulates PANoptosis to Improve Immune Microenvironment in Diabetic Nephropathy: A Machine Learning–Based Mechanistic Analysis
Diabetic nephropathy (DN) is characterized by nephron degeneration induced by hyperglycemia, driven by complex interaction...
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