Joseph, P., Leong, D., McKee, M., Anand, S. S., Schwalm, J. D., Teo, K., Mente, A., & Yusuf, S. (2017). Reducing the global burden of cardiovascular disease, part 1: The epidemiology and risk factors. Circulation Research, 121(6), 677–694. https://doi.org/10.1161/CIRCRESAHA.117.308903
Article PubMed CAS Google Scholar
Vaduganathan, M., Mensah, G. A., Turco, J. V., Fuster, V., & Roth, G. A. (2022). The global burden of cardiovascular diseases and risk. Journal of the American College of Cardiology, 80(25), 2361–2371. https://doi.org/10.1016/j.jacc.2022.11.005
Rodgers, J. L., Jones, J., Bolleddu, S. I., Vanthenapalli, S., Rodgers, L. E., Shah, K., Karia, K., & Panguluri, S. K. (2019). Cardiovascular risks associated with gender and aging. Journal of Cardiovascular Development and Disease, 6(2), 19. https://doi.org/10.3390/jcdd6020019
Article PubMed PubMed Central CAS Google Scholar
Komalasari, R., Nurjanah, & Yoche, M. M. (n.d.). Quality of life of people with cardiovascular disease: A descriptive study. Asian/Pacific Island Nursing Journal, 4(2), 92–96. https://doi.org/10.31372/20190402.1045
Sheydina, A., Riordon, D. R., & Boheler, K. R. (2011). Molecular mechanisms of cardiomyocyte aging. Clinical Science, 121(8), 315–329. https://doi.org/10.1042/CS20110115
Article PubMed CAS Google Scholar
Kang, P. M., & Izumo, S. (2003). Apoptosis in heart: Basic mechanisms and implications in cardiovascular diseases. Trends in Molecular Medicine, 9(4), 177–182. https://doi.org/10.1016/s1471-4914(03)00025-x
Article PubMed CAS Google Scholar
Biernacka, A., & Frangogiannis, N. G. (2011). Aging and cardiac fibrosis. Aging and Disease, 2(2), 158–173.
PubMed PubMed Central Google Scholar
Calcinotto, A., Kohli, J., Zagato, E., Pellegrini, L., Demaria, M., & Alimonti, A. (2019). Cellular senescence: Aging, cancer, and injury. Physiological Reviews, 99(2), 1047–1078. https://doi.org/10.1152/physrev.00020.2018
Article PubMed CAS Google Scholar
Li, W., Wang, H., Tan, Y., Wang, Y., Yu, S., & Li, Z. (2021). Reducing Lipofuscin accumulation and cardiomyocytic senescence of aging heart by enhancing autophagy. Experimental Cell Research, 403(1), 112585. https://doi.org/10.1016/j.yexcr.2021.112585
Article PubMed CAS Google Scholar
Cesarovic, N., Lipiski, M., Falk, V., & Emmert, M. Y. (2020). Animals in cardiovascular research: Clinical relevance and translational limitations of animal models in cardiovascular medicine. European Heart Journal, 41(2), 200–203. https://doi.org/10.1093/eurheartj/ehz933
Article PubMed CAS Google Scholar
Fine, B., & Vunjak-Novakovic, G. (2017). Shortcomings of animal models and the rise of engineered human cardiac tissue. ACS Biomaterials Science & Engineering, 3(9), 1884–1897. https://doi.org/10.1021/acsbiomaterials.6b00662
Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007). Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell, 131(5), 861–872. https://doi.org/10.1016/j.cell.2007.11.019
Article PubMed CAS Google Scholar
Takahashi, K., & Yamanaka, S. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell, 126(4), 663–676. https://doi.org/10.1016/j.cell.2006.07.024
Article PubMed CAS Google Scholar
Acun, A., Nguyen, T. D., & Zorlutuna, P. (2019). In vitro aged, hiPSC-origin engineered heart tissue models with age-dependent functional deterioration to study myocardial infarction. Acta Biomaterialia, 94, 372–391. https://doi.org/10.1016/j.actbio.2019.05.064
Article PubMed PubMed Central CAS Google Scholar
Guo, B., Guo, Q., Wang, Z., Shao, J. B., Liu, K., Du, Z. D., & Gong, S. S. (2020). d-Galactose-induced oxidative stress and mitochondrial dysfunction in the cochlear Basilar membrane: An in vitro aging model. Biogerontology, 21(3), 311–323. https://doi.org/10.1007/s10522-020-09859-x
Article PubMed PubMed Central CAS Google Scholar
Acun, A., Vural, D. C., & Zorlutuna, P. (2017). A tissue engineered model of aging: Interdependence and cooperative effects in failing tissues. Scientific Reports, 7(1), 5051. https://doi.org/10.1038/s41598-017-05098-2
Article PubMed PubMed Central CAS Google Scholar
Sharples, A. P., Player, D. J., Martin, N. R. W., Mudera, V., Stewart, C. E., & Lewis, M. P. (2012). Modelling in vivo skeletal muscle ageing in vitro using three-dimensional bioengineered constructs. Aging Cell, 11(6), 986–995. https://doi.org/10.1111/j.1474-9726.2012.00869.x
Article PubMed CAS Google Scholar
Bokov, A., Chaudhuri, A., & Richardson, A. (2004). The role of oxidative damage and stress in aging. Mechanisms of Ageing and Development, 125(10), 811–826. https://doi.org/10.1016/j.mad.2004.07.009
Article PubMed CAS Google Scholar
Dröge, W. (2003). Oxidative Stress and Aging. In R. C. Roach, P. D. Wagner, & P. H. Hackett (Eds.), Hypoxia (pp. 191–200). Springer US. https://doi.org/10.1007/978-1-4419-8997-0_14
Sohal, R. S., & Sohal, B. H. (1991). Hydrogen peroxide release by mitochondria increases during aging. Mechanisms of Ageing and Development, 57(2), 187–202. https://doi.org/10.1016/0047-6374(91)90034-w
Article PubMed CAS Google Scholar
Sagar, S., & Gustafsson, A. B. (2023). Cardiovascular aging: The mitochondrial influence. The Journal of Cardiovascular Aging, 3(3), 33. https://doi.org/10.20517/jca.2023.22
Article PubMed PubMed Central CAS Google Scholar
Pollack, M., & Leeuwenburgh, C. (2001). Apoptosis and aging: Role of the mitochondria. The Journals of Gerontology: Series A, 56(11), B475–B482. https://doi.org/10.1093/gerona/56.11.B475
Pollack, M., Phaneuf, S., Dirks, A., & Leeuwenburgh, C. (2002). The role of apoptosis in the normal aging brain, skeletal muscle, and heart. Annals of the New York Academy of Sciences, 959, 93–107. https://doi.org/10.1111/j.1749-6632.2002.tb02086.x
Article PubMed CAS Google Scholar
Lian, X., Zhang, J., Azarin, S. M., Zhu, K., Hazeltine, L. B., Bao, X., Hsiao, C., Kamp, T. J., & Palecek, S. P. (2013). Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions. Nature Protocols, 8, 162–175. https://doi.org/10.1038/nprot.2012.150
Article PubMed CAS Google Scholar
Costello, L., Dicolandrea, T., Tasseff, R., Isfort, R., Bascom, C., von Zglinicki, T., & Przyborski, S. (2022). Tissue engineering strategies to bioengineer the ageing skin phenotype in vitro. Aging Cell, 21(2), e13550. https://doi.org/10.1111/acel.13550
Article PubMed PubMed Central CAS Google Scholar
Hetzer, M. W., & Bersini, S. (2022). Beyond static pipes: Mechanisms and in vitro models of vascular aging. Cold Spring Harbor Perspectives in Medicine, a041180. https://doi.org/10.1101/cshperspect.a041180
Piccini, I., Rao, J., Seebohm, G., & Greber, B. (2015). Human pluripotent stem cell-derived cardiomyocytes: Genome-wide expression profiling of long-term in vitro maturation in comparison to human heart tissue. Genomics Data, 4, 69–72. https://doi.org/10.1016/j.gdata.2015.03.008
Article PubMed PubMed Central Google Scholar
Liguori, I., Russo, G., Curcio, F., Bulli, G., Aran, L., Della-Morte, D., Gargiulo, G., Testa, G., Cacciatore, F., Bonaduce, D., & Abete, P. (2018). Oxidative stress, aging, and diseases. Clinical Interventions in Aging, 13, 757–772. https://doi.org/10.2147/CIA.S158513
Article PubMed PubMed Central CAS Google Scholar
Manzella, N., Santin, Y., Maggiorani, D., Martini, H., Douin-Echinard, V., Passos, J. F., Lezoualc’h, F., Binda, C., Parini, A., & Mialet-Perez, J. (2018). Monoamine oxidase-A is a novel driver of stress-induced premature senescence through Inhibition of parkin-mediated mitophagy. Aging Cell, 17(5), e12811. https://doi.org/10.1111/acel.12811
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