Treating Post-Cataract Posterior Capsule Opacification: The Relationship Between Myofibroblast Concentration on Lens Capsule Wrinkling

Bourne RR, Steinmetz JD, Saylan M, et al. Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: The Right to Sight: An analysis for the Global Burden of Disease Study. Lancet Glob Health. 2021;9(2):e144–60.

Article  Google Scholar 

Gollogly HE, Hodge DO, Sauver JL, et al. Increasing incidence of cataract surgery: population-based study. J Cataract Refract Surg. 2013;39(9):1383–9.

Article  PubMed  PubMed Central  Google Scholar 

Zernii EY, Baksheeva VE, Iomdina EN, et al. Rabbit models of ocular diseases: new relevance for classical approaches. CNS & Neurological Disorders. 2016;15(3):267–91.

Article  CAS  Google Scholar 

Mylona I, Tsinopoulos I. A critical appraisal of new developments in intraocular lens modifications and drug delivery systems for the prevention of cataract surgery complications. Pharmaceuticals. 2020;13(12): 448.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Raj SM, Vasavada AR, Johar SK, et al. Post-operative capsular opacification: a review. International journal of biomedical science: IJBS. 2007;3(4):237.

Article  PubMed  PubMed Central  Google Scholar 

Awasthi N, Guo S, Wagner BJ. Posterior capsular opacification: a problem reduced but not yet eradicated. Arch Ophthalmol. 2009;127(4):555–62.

Article  PubMed  Google Scholar 

Hashemi H, Majdi M, Akbar Fotouhi MD, et al. Posterior capsule opacification after cataract surgery and its determinants. Journal of Current Ophthalmology. 2012;24(2):3.

Google Scholar 

Osorno LL, Medina JD, Maldonado DE, et al. Extended release of doxorubicin-loaded 3DNA nanocarriers from in-situ forming, self-assembled hydrogels. J Ocul Pharmacol Ther. 2020;36(6):447–57.

Article  CAS  PubMed  Google Scholar 

Osorno LL, Mosley RJ, Poley PL, et al. Sustained release of antibody-conjugated DNA nanocarriers from a novel injectable hydrogel for targeted cell depletion to treat cataract posterior capsule opacification. J Ocul Pharmacol Ther. 2022;38(6):404–11.

CAS  PubMed  Google Scholar 

Vardar C, George-Weinstein M, Getts R, et al. Evaluation of dose-response relationship in novel extended release of targeted nucleic acid nanocarriers to treat secondary cataracts. J Ocul Pharmacol Ther. 2024;40(7):459–66.

Article  CAS  PubMed  Google Scholar 

Wormstone IM, Tamiya S, Anderson I, et al. TGF-β2–induced matrix modification and cell transdifferentiation in the human lens capsular bag. Invest Ophthalmol Vis Sci. 2002;43(7):2301–8.

PubMed  Google Scholar 

Gotoh N, Perdue NR, Matsushima H, et al. An in vitro model of posterior capsular opacity: SPARC and TGF-β2 minimize epithelial-to-mesenchymal transition in lens epithelium. Invest Ophthalmol Vis Sci. 2007;48(10):4679–87.

Article  PubMed  Google Scholar 

Marcantonio JM, Vrensen GF. Cell biology of posterior capsular opacification. Eye. 1999;13(3):484–8.

Article  PubMed  Google Scholar 

Eldred JA, Dawes LJ, Wormstone IM. The lens as a model for fibrotic disease. Philos Trans R Soc Lond B Biol Sci. 2011;366(1568):1301–19.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cooksley G, Lacey J, Dymond MK, et al. Factors affecting posterior capsule opacification in the development of intraocular lens materials. Pharmaceutics. 2021;13(6): 860.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Y, Zhao J, Yin Y, et al. The role of IL-6 in fibrotic diseases: molecular and cellular mechanisms. Int J Biol Sci. 2022;18(14):5405.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yan W, Zhang Y, Cao J, et al. TGF-β 2 levels in the aqueous humor are elevated in the second eye of high myopia within two weeks after sequential cataract surgery. Sci Rep. 2022;12(1): 17974.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Frangogiannis NG. Transforming growth factor-beta in tissue fibrosis. J Exp Med. 2020;217:e20190103.

Lee EH, Joo CK. Role of transforming growth factor-β in transdifferentiation and fibrosis of lens epithelial cells. Invest Ophthalmol Vis Sci. 1999;40(9):2025–32.

CAS  PubMed  Google Scholar 

Meacock WR, Spalton DJ, Stanford MR. Role of cytokines in the pathogenesis of posterior capsule opacification. Br J Ophthalmol. 2000;84(3):332–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bisevac J, Anisimova NS, Nagymihály R, et al. Long-term myofibroblast persistence in the capsular bag contributes to the late spontaneous in-the-bag intraocular lens dislocation. Sci Rep. 2020;10(1): 20532.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dawes LJ, Angell H, Sleeman M, et al. TGFβ isoform dependent Smad2/3 kinetics in human lens epithelial cells: a Cellomics analysis. Exp Eye Res. 2007;84(5):1009–12.

Article  CAS  PubMed  Google Scholar 

Boswell BA, Korol A, West-Mays JA, et al. Dual function of TGFβ in lens epithelial cell fate: implications for secondary cataract. Mol Biol Cell. 2017;28(7):907–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Saika S, Okada Y, Miyamoto T, et al. Smad translocation and growth suppression in lens epithelial cells by endogenous TGFβ2 during wound repair. Exp Eye Res. 2001;72(6):679–86.

Article  CAS  PubMed  Google Scholar 

Gerhart J, Greenbaum M, Scheinfeld V, et al. Myo/Nog cells: targets for preventing the accumulation of skeletal muscle-like cells in the human lens. PLoS One. 2014;9(4): e95262.

Article  PubMed  PubMed Central  Google Scholar 

Gerhart J, Withers C, Gerhart C, et al. Myo/Nog cells are present in the ciliary processes, on the zonule of Zinn and posterior capsule of the lens following cataract surgery. Exp Eye Res. 2018;1(171):101–5.

Article  Google Scholar 

Gerhart J, Hayes C, Scheinfeld V, et al. M yo/N og cells in normal, wounded and tumor-bearing skin. Exp Dermatol. 2012;21(6):466–8.

Article  PubMed  PubMed Central  Google Scholar 

Gerhart J, Scheinfeld VL, Milito T, et al. Myo/Nog cell regulation of bone morphogenetic protein signaling in the blastocyst is essential for normal morphogenesis and striated muscle lineage specification. Dev Biol. 2011;359(1):12–25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gerhart J, Neely C, Elder J, et al. Cells that express MyoD mRNA in the epiblast are stably committed to the skeletal muscle lineage. J Cell Biol. 2007;178(4):649–60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gerhart J, Bast B, Neely C, et al. MyoD-positive myoblasts are present in mature fetal organs lacking skeletal muscle. J Cell Biol. 2001;155(3):381–92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

West-Mays JA, Korol A. The lens capsule: synthesis, remodeling, and MMPs. In: Lens epithelium and posterior capsular opacification. Tokyo: Springer Japan; 2014. p. 39–57.

Wormstone IM, Wormstone YM, Smith AJ, et al. Posterior capsule opacification: what’s in the bag? Prog Retin Eye Res. 2021;82: 100905.

Article  CAS  PubMed  Google Scholar 

Eming SA, Krieg T, Davidson JM. Inflammation in wound repair: molecular and cellular mechanisms. J Invest Dermatol. 2007;127(3):514–25.

Article  CAS  PubMed  Google Scholar 

Werner S, Grose R. Regulation of wound healing by growth factors and cytokines. Physiol Rev. 2003;83(3):835–70.

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