Pacifici GM. Clinical pharmacology of fentanyl in preterm infants. A review. Pediatr Neonatol. 2015;56:143–8.
Ziesenitz VC, Vaughns JD, Koch G, Mikus G, van den Anker JN. Pharmacokinetics of fentanyl and its derivatives in children: a comprehensive review. Clin Pharmacokinet. 2018;57:125–49.
Article CAS PubMed PubMed Central Google Scholar
Aranda JV, Carlo W, Hummel P, Thomas R, Lehr VT, Anand KJS. Analgesia and sedation during mechanical ventilation in neonates. Clin Ther. 2005;27:877–99.
Article CAS PubMed Google Scholar
Hughes CG, McGrane S, Pandharipande PP. Sedation in the intensive care setting. Clin Pharmacol Adv Appl. 2012;4:53–63.
Fentanyl citrate [package insert]. Hospira Inc. Pfizer Inc; Lake Forest, IL. [Internet]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/019115s030s031lbl.pdf. Accessed Dec 2016.
Oshikoya KA, Wharton GT, Avant D, Van Driest SL, Fenn NE, Lardieri A, et al. Serious adverse events associated with off-label use of azithromycin or fentanyl in children in intensive care units: a retrospective chart review. Paediatr Drugs. 2019;21:47–58.
Article PubMed PubMed Central Google Scholar
Ward RM, Sherwin CMT. Ethics of drug studies in the newborn. Paediatr Drugs. 2015;17:37–42.
Bellanti F, Della Pasqua O. Modelling and simulation as research tools in paediatric drug development. Eur J Clin Pharmacol. 2011;67(Suppl 1):75–86.
Article CAS PubMed PubMed Central Google Scholar
Encinas E, Calvo R, Lukas JC, Vozmediano V, Rodriguez M, Suarez E. A predictive pharmacokinetic/pharmacodynamic model of fentanyl for analgesia/sedation in neonates based on a semi-physiologic approach. Paediatr Drugs. 2013;15:247–57.
Bista SR, Haywood A, Hardy J, Lobb M, Tapuni A, Norris R. Protein binding of fentanyl and its metabolite nor-fentanyl in human plasma, albumin and α-1 acid glycoprotein. Xenobiotica. 2015;45:207–12.
Article CAS PubMed Google Scholar
Li H, Lampe JN. Neonatal cytochrome P450 CYP3A7: a comprehensive review of its role in development, disease, and xenobiotic metabolism. Arch Biochem Biophys. 2019;673:108078.
Article CAS PubMed PubMed Central Google Scholar
Anderson BJ, Holford NHG. Mechanistic basis of using body size and maturation to predict clearance in humans. Drug Metab Pharmacokinet. 2009;24:25–36.
Article CAS PubMed Google Scholar
Jamei M, Marciniak S, Feng K, Barnett A, Tucker G, Rostami-Hodjegan A. The Simcyp ® population-based ADME simulator. Expert Opin Drug Metab Toxicol. 2009;5:211–23.
Article CAS PubMed Google Scholar
Wojtyniak J-G, Britz H, Selzer D, Schwab M, Lehr T. Data digitizing: accurate and precise data extraction for quantitative systems pharmacology and physiologically-based pharmacokinetic modeling. CPT Pharmacomet Syst Pharmacol. 2020;9:322–31.
R: The R Project for Statistical Computing [Internet]. https://www.r-project.org/. Accessed 29 Feb 2024.
Cui C, Valerie Sia JE, Tu S, Li X, Dong Z, Yu Z, et al. Development of a physiologically based pharmacokinetic (PBPK) population model for Chinese elderly subjects. Br J Clin Pharmacol. 2021;87:2711–22.
Article CAS PubMed Google Scholar
Cayabyab R, Arora V, Wertheimer F, Durand M, Ramanathan R. Graded oxygen saturation targets and retinopathy of prematurity in extremely preterm infants. Pediatr Res. 2016;80:401–6.
Article CAS PubMed Google Scholar
Chang M. Optimal oxygen saturation in premature infants. Korean J Pediatr. 2011;54:359–62.
Article CAS PubMed PubMed Central Google Scholar
Sola A, Golombek SG, Montes Bueno MT, Lemus-Varela L, Zuluaga C, Domínguez F, et al. Safe oxygen saturation targeting and monitoring in preterm infants: can we avoid hypoxia and hyperoxia? Acta Paediatr. 2014;103:1009–18.
Article PubMed PubMed Central Google Scholar
Zubrow AB, Hulman S, Kushner H, Falkner B. Determinants of blood pressure in infants admitted to neonatal intensive care units: a prospective multicenter study. Philadelphia Neonatal Blood Pressure Study Group. J Perinatol. 1995;15:470–9.
McClain DA, Hug CC. Intravenous fentanyl kinetics. Clin Pharmacol Ther. 1980;28:106–14.
Article CAS PubMed Google Scholar
Saari TI, Laine K, Neuvonen M, Neuvonen PJ, Olkkola KT. Effect of voriconazole and fluconazole on the pharmacokinetics of intravenous fentanyl. Eur J Clin Pharmacol. 2008;64:25–30.
Article CAS PubMed Google Scholar
Ibrahim AE, Feldman J, Karim A, Kharasch ED. Simultaneous assessment of drug interactions with low- and high-extraction opioids: application to parecoxib effects on the pharmacokinetics and pharmacodynamics of fentanyl and alfentanil. Anesthesiology. 2003;98:853–61.
Article CAS PubMed Google Scholar
Ziesenitz VC, König SK, Mahlke NS, Skopp G, Haefeli WE, Mikus G. Pharmacokinetic interaction of intravenous fentanyl with ketoconazole. J Clin Pharmacol. 2015;55:708–17.
Article CAS PubMed Google Scholar
Olkkola KT, Palkama VJ, Neuvonen PJ. Ritonavir’s role in reducing fentanyl clearance and prolonging its half-life. Anesthesiology. 1999;91:681–5.
Article CAS PubMed Google Scholar
Palkama VJ, Neuvonen PJ, Olkkola KT. The CYP 3A4 inhibitor itraconazole has no effect on the pharmacokinetics of i.v. fentanyl. Br J Anaesth. 1998;81:598–600.
Article CAS PubMed Google Scholar
Macleod DB, Habib AS, Ikeda K, Spyker DA, Cassella JV, Ho KY, et al. Inhaled fentanyl aerosol in healthy volunteers: pharmacokinetics and pharmacodynamics. Anesth Analg. 2012;115:1071–7.
Article CAS PubMed Google Scholar
Streisand JB, Varvel JR, Stanski DR, Le Maire L, Ashburn MA, Hague BI, et al. Absorption and bioavailability of oral transmucosal fentanyl citrate. Anesthesiology. 1991;75:223–9.
Article CAS PubMed Google Scholar
Cartwright P, Prys-Roberts C, Gill K, Dye A, Stafford M, Gray A. Ventilatory depression related to plasma fentanyl concentrations during and after anesthesia in humans. Anesth Analg. 1983;62:966–74.
Article CAS PubMed Google Scholar
Nozari A, Akeju O, Mirzakhani H, Eskandar E, Ma Z, Hossain MA, et al. Prolonged therapy with the anticonvulsant carbamazepine leads to increased plasma clearance of fentanyl. J Pharm Pharmacol. 2019;71:982–7.
Article CAS PubMed PubMed Central Google Scholar
Schulz M, Schmoldt A, Andresen-Streichert H, Iwersen-Bergmann S. Revisited: Therapeutic and toxic blood concentrations of more than 1100 drugs and other xenobiotics. Crit Care. 2020;24:195.
Article PubMed PubMed Central Google Scholar
Argikar UA, Potter PM, Hutzler JM, Marathe PH. Challenges and opportunities with non-CYP enzymes aldehyde oxidase, carboxylesterase, and UDP-glucuronosyltransferase: focus on reaction phenotyping and prediction of human clearance. AAPS J. 2016;18:1391–405.
Article CAS PubMed Google Scholar
Wu Y, Völler S, Flint RB, Simons SHP, Allegaert K, Fellman V, et al. Pre- and postnatal maturation are important for fentanyl exposure in preterm and term newborns: a pooled population pharmacokinetic study. Clin Pharmacokinet. 2022;61:401–12.
Comments (0)