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Drug–Drug Interactions Between Direct Oral Anticoagulants and Other Medications in Patients with Pulmonary Embolism: Results from the Lungenembolie Augsburg (LEA)
Drug–Drug Interactions Between Direct Oral Anticoagulants and Other Medications in Patients with Pulmonary Embolism: Results from the Lungenembolie Augsburg (LEA)
Direct oral anticoagulants (DOACs) are now a well-established class of medication for blood clot prevention and treatment....
A Tacrolimus Population Pharmacokinetic Model for Adult Allogeneic Hematopoietic Cell Transplant Recipients Provides Clinical Opportunities for Precision Dosing
A Tacrolimus Population Pharmacokinetic Model for Adult Allogeneic Hematopoietic Cell Transplant Recipients Provides Clinical Opportunities for Precision Dosing
Tacrolimus is a cornerstone of acute graft-versus-host disease (aGVHD) prophylaxis in allogeneic hematopoietic cell transp...
Malnutrition and Its Effect on Drug Pharmacokinetics: A Clinical Perspective
Malnutrition and Its Effect on Drug Pharmacokinetics: A Clinical Perspective
Malnutrition significantly alters the pharmacokinetics of medications, particularly in vulnerable populations such as chil...
Double Peaking Phenomena in Pharmacokinetic Disposition Revisited
Double Peaking Phenomena in Pharmacokinetic Disposition Revisited
Multiple peaking in pharmacokinetics refers to the occurrence of two or more peaks of drug plasma concentrations following...
Clinical Pharmacology Profile of the Claudin 18.2 Antibody Zolbetuximab
Clinical Pharmacology Profile of the Claudin 18.2 Antibody Zolbetuximab
Zolbetuximab is a first-in-class chimeric (mouse/human) monoclonal antibody targeted to the tight junction protein claudin...
Methodological Techniques Used in Machine Learning to Support Individualized Drug Dosing Regimens Based on Pharmacokinetic Data: A Scoping Review
Methodological Techniques Used in Machine Learning to Support Individualized Drug Dosing Regimens Based on Pharmacokinetic Data: A Scoping Review
Individualized drug dosing is a highly effective strategy for optimizing therapeutic outcomes, especially for drugs with h...
Immunoglobulin G Receptors (FcγR), in Addition to Target-Antigen and Neonatal Fc Receptor (FcRn), Influence Rituximab Pharmacokinetics
Immunoglobulin G Receptors (FcγR), in Addition to Target-Antigen and Neonatal Fc Receptor (FcRn), Influence Rituximab Pharmacokinetics
Rituximab, an anti-cluster of differentiation (CD)-20 monoclonal antibody, is used in the treatment of non-Hodgkin lymphom...
Challenging Traditional ADME Assumptions for Physiologically Based Pharmacokinetic Models for Intravenous Administration of Iron–Carbohydrate Nanomedicines: Potential Utility of Gold Nanoparticle Models as a Roadmap
Challenging Traditional ADME Assumptions for Physiologically Based Pharmacokinetic Models for Intravenous Administration of Iron–Carbohydrate Nanomedicines: Potential Utility of Gold Nanoparticle Models as a Roadmap
Intravenous iron–carbohydrate complexes are a class of nanomedicines that are widely used globally to treat iron def...
Evaluation of Preliminary Bronchodilation Effect on Aerosol Delivery from a Dry Powder Inhaler for Patients with Chronic Obstructive Pulmonary Disease with Suboptimal Peak Inspiratory Flow Rate
Evaluation of Preliminary Bronchodilation Effect on Aerosol Delivery from a Dry Powder Inhaler for Patients with Chronic Obstructive Pulmonary Disease with Suboptimal Peak Inspiratory Flow Rate
Suboptimal peak inspiratory flow rates (PIFR) are common in patients with chronic obstructive pulmonary disease (COPD), hi...
Hybrid Population Pharmacokinetic–Machine Learning Modeling to Predict Infliximab Pharmacokinetics in Pediatric and Young Adult Patients with Crohn’s Disease
Hybrid Population Pharmacokinetic–Machine Learning Modeling to Predict Infliximab Pharmacokinetics in Pediatric and Young Adult Patients with Crohn’s Disease
Population pharmacokinetic (PK) model-based Bayesian estimation is widely used for dose individualization, particularly wh...
Paracetamol Concentrations and Time-Course of Ductus Arteriosus Diameter in Extremely Preterm Neonates: A Population Pharmacokinetic–Pharmacodynamic Analysis
Paracetamol Concentrations and Time-Course of Ductus Arteriosus Diameter in Extremely Preterm Neonates: A Population Pharmacokinetic–Pharmacodynamic Analysis
Patent ductus arteriosus is a common complication of extreme prematurity. Prophylactic treatment with indomethacin or ibup...
Population Pharmacokinetic Modeling of Canagliflozin in Advanced Chronic Kidney Disease
Population Pharmacokinetic Modeling of Canagliflozin in Advanced Chronic Kidney Disease
Canagliflozin is an orally active, selective, reversible sodium-glucose cotransport-2 (SGLT-2) inhibitor used in patients ...
Modeling Whole-Body Dynamic PET Microdosing Data to Predict the Whole-Body Pharmacokinetics of Glyburide in Humans
Modeling Whole-Body Dynamic PET Microdosing Data to Predict the Whole-Body Pharmacokinetics of Glyburide in Humans
Whole-body dynamic (WB4D) positron emission tomography (PET) imaging data using radiolabeled analogs of drugs are mostly a...
Population Pharmacokinetic Analysis of Balcinrenone in Healthy Participants and Participants with Heart Failure and Chronic Kidney Disease
Population Pharmacokinetic Analysis of Balcinrenone in Healthy Participants and Participants with Heart Failure and Chronic Kidney Disease
Balcinrenone is a novel mineralocorticoid receptor modulator which, based on preclinical data, maintains cardio-renal bene...
Exposure–Response Analysis of Efsubaglutide Alfa in Patients with Type 2 Diabetes Treated with Metformin
Exposure–Response Analysis of Efsubaglutide Alfa in Patients with Type 2 Diabetes Treated with Metformin
Efsubaglutide alfa is a long-acting GLP-1 receptor agonist and is designed by fusion of two human GLP-1 molecules with IgG...
Evaluation of Fentanyl-Emerged Adverse Events and Pharmacokinetics in Neonates: A Physiologically Based Pharmacokinetic Modeling Approach
Evaluation of Fentanyl-Emerged Adverse Events and Pharmacokinetics in Neonates: A Physiologically Based Pharmacokinetic Modeling Approach
Despite its common use for analgesia in neonatal intensive care units, the optimal dosing and safety profile of fentanyl, ...
PEGylated Proteins: How Much Does Molecular Weight Matter?
PEGylated Proteins: How Much Does Molecular Weight Matter?
Polyethylene glycols (PEGs) are inert polymers of repeating ethylene oxide subunits. Attaching PEGs to therapeutic protein...
A Physiologically Based Pharmacokinetic Model for the Prediction of Plasma and Bone Tissue Exposure after Prophylactic Administration of Ampicillin/Sulbactam in Patients with Osteonecrosis of the Jaw
A Physiologically Based Pharmacokinetic Model for the Prediction of Plasma and Bone Tissue Exposure after Prophylactic Administration of Ampicillin/Sulbactam in Patients with Osteonecrosis of the Jaw
The combination of ampicillin (AMP) together with sulbactam (SBC) is a widely used choice for infection prophylaxis in the...
Prediction of Maternal and Fetal Exposure to Escitalopram, Sertraline, and Paroxetine by Combining Human Ex Vivo Placenta Perfusion Data and Physiologically Based Pharmacokinetic Modeling
Prediction of Maternal and Fetal Exposure to Escitalopram, Sertraline, and Paroxetine by Combining Human Ex Vivo Placenta Perfusion Data and Physiologically Based Pharmacokinetic Modeling
Depression is common in pregnant women, and selective serotonin reuptake inhibitors (SSRIs) are the most widely used antid...
Evaluation of the Effect of Risankizumab on the Pharmacokinetics of Cytochrome P450 Substrates in Patients with Moderately to Severely Active Ulcerative Colitis or Crohn’s Disease
Evaluation of the Effect of Risankizumab on the Pharmacokinetics of Cytochrome P450 Substrates in Patients with Moderately to Severely Active Ulcerative Colitis or Crohn’s Disease
The objective of this study was to characterize the effects of risankizumab on the pharmacokinetics of cytochrome P450 (CY...
Exposure to Rifampicin and its Metabolite 25-Deacetylrifampicin Rapidly Decreases During Tuberculosis Therapy
Exposure to Rifampicin and its Metabolite 25-Deacetylrifampicin Rapidly Decreases During Tuberculosis Therapy
Limited information is available on the pharmacokinetics of rifampicin (RIF) along with that of its active metabolite, 25-...
Identifying the Optimal Sampling Strategy for the Bayesian Estimation of Vancomycin AUC0–24 in Adult Hematologic Cancer Patients
Identifying the Optimal Sampling Strategy for the Bayesian Estimation of Vancomycin AUC0–24 in Adult Hematologic Cancer Patients
The latest consensus recommends using the ratio between the area under the curve over 24 h (AUC0–24) and minimal inh...
Population Pharmacokinetics of Telmisartan in Healthy Subjects and Hypertensive Patients
Population Pharmacokinetics of Telmisartan in Healthy Subjects and Hypertensive Patients
Telmisartan exhibits significant pharmacokinetic (PK) variability, but it remains unclear whether its PK profile is altere...
Clinical Pharmacokinetics of N,N-Dimethyltryptamine (DMT): A Systematic Review and Post-hoc Analysis
Clinical Pharmacokinetics of N,N-Dimethyltryptamine (DMT): A Systematic Review and Post-hoc Analysis
N,N-Dimethyltryptamine (DMT) is currently being studied for its therapeutic potential in various psychiatric disorders. An...
All You Need to Know About Allometric Scaling: An Integrative Review on the Theoretical Basis, Empirical Evidence, and Application in Human Pharmacology
All You Need to Know About Allometric Scaling: An Integrative Review on the Theoretical Basis, Empirical Evidence, and Application in Human Pharmacology
Scaling approaches are used to describe or predict clearance for paediatric or obese populations from normal-weight adult ...
Dose Optimization of Vancomycin in Pediatric Post-Cardiac Surgery Patients: A Population Pharmacokinetic Modeling Study
Dose Optimization of Vancomycin in Pediatric Post-Cardiac Surgery Patients: A Population Pharmacokinetic Modeling Study
Vancomycin is a glycopeptide antibiotic used for the treatment of severe gram-positive infections. Despite decades of clin...
Improving Understanding of Fexofenadine Pharmacokinetics to Assess Pgp Phenotypic Activity in Older Adult Patients Using Population Pharmacokinetic Modeling
Improving Understanding of Fexofenadine Pharmacokinetics to Assess Pgp Phenotypic Activity in Older Adult Patients Using Population Pharmacokinetic Modeling
Fexofenadine is commonly used as a probe substrate to assess P-glycoprotein (Pgp) activity. While its use in healthy volun...
Clinical Pharmacokinetics of Antitubercular Drugs in the Overweight and Obese Population: Implications for Dosage Adjustments
Clinical Pharmacokinetics of Antitubercular Drugs in the Overweight and Obese Population: Implications for Dosage Adjustments
The rise in global obesity prevalence has increased the need to understand the pharmacokinetics of drugs in overweight and...
Population Pharmacokinetic Modelling of Apixaban in End-Stage Kidney Disease Patients with Atrial Fibrillation Receiving Haemodialysis
Population Pharmacokinetic Modelling of Apixaban in End-Stage Kidney Disease Patients with Atrial Fibrillation Receiving Haemodialysis
Apixaban is increasingly being used for stroke prevention in patients with end-stage kidney disease with atrial f...
Physiologically Based Pharmacokinetic Model of Cefotaxime in Patients with Impaired Renal Function
Physiologically Based Pharmacokinetic Model of Cefotaxime in Patients with Impaired Renal Function
Cefotaxime is a widely prescribed cephalosporin antibiotic used to treat various infections. It is mainly eliminated uncha...
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