Candido do Prado L G, Lopes J G, Lopes-Olhê F C, Magri L V, Mazzi-Chaves J F. Individual risk factors associated with post-traumatic trigeminal neuropathy following endodontic procedures: a systematic review. J Endod 2025; DOI: 10.1016/j.joen.2025.09.009.

Female sex, psychological vulnerability, and altered sensory modulation may be individual-level risk factors for post-traumatic trigeminal neuropathy following endodontic treatment

This systemic review aimed to identify patient-specific phenotypic, anatomical, psychological, and clinical risk factors associated with the development of post-traumatic trigeminal neuropathy (PTTN) following endodontic procedures. Studies were eligible if they reported patient-level phenotypic, anatomical, psychological, or clinical features linked to PTTN following endodontic therapy. Nine studies were included. A predominance of female patients among those with PTTN was observed, with a pooled proportion of 67%. Psychological comorbidities, such as anxiety and depression, previous chronic pain conditions, and endodontic procedures in anatomically high-risk areas, particularly mandibular molars, were also identified as potential risk factors. Some studies proposed predictive frameworks integrating sensory testing and patient history. Heterogeneity in study designs and limited quantitative data prevented subgroup analyses.