Identification of potential causal-genes-relevant blood pressure: a mitochondria-related genome-wide Mendelian randomization study

Mills KT, Stefanescu A, He J. The global epidemiology of hypertension. Nat Rev, Nephrol. 2020;16:223–37.

Article  CAS  PubMed  Google Scholar 

Chou Y-T, Chen H-Y, Shen W-C, Wu I-H, Su F-L, Lee W-H, et al. Blood pressure levels within normotensive range are independently associated with increased risk of arterial stiffness in adults without hypertension or prehypertension. Nutr Metab Cardiovasc Dis: NMCD. 2023;33:2363–71.

Article  PubMed  Google Scholar 

Eirin A, Lerman A, Lerman LO. Mitochondrial injury and dysfunction in hypertension-induced cardiac damage. Eur Heart J. 2014;35:3258–66.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wilson FH, Hariri A, Farhi A, Zhao H, Petersen KF, Toka HR, et al. A cluster of metabolic defects caused by mutation in a mitochondrial tRNA. Sci. 2004;306:1190–4.

Article  CAS  Google Scholar 

Preston KJ, Kawai T, Torimoto K, Kuroda R, Nakayama Y, Akiyama T, et al. Mitochondrial fission inhibition protects against hypertension induced by angiotensin II. Hypertens Res: Off J Jpn Soc Hypertens. 2024;47:1338–49.

Article  CAS  Google Scholar 

Forte M, Stanzione R, Cotugno M, Bianchi F, Marchitti S, Rubattu S. Vascular ageing in hypertension: focus on mitochondria. Mech Ageing Dev. 2020;189:111267.

Article  CAS  PubMed  Google Scholar 

Rath S, Sharma R, Gupta R, Ast T, Chan C, Durham TJ, et al. MitoCarta3.0: An updated mitochondrial proteome now with sub-organelle localization and pathway annotations. Nucleic Acids Res. 2021;49:D1541–D1547.

Article  CAS  PubMed  Google Scholar 

Võsa U, Claringbould A, Westra H-J, Bonder MJ, Deelen P, Zeng B, et al. Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression. Nat Genet. 2021;53:1300–10.

Article  PubMed  PubMed Central  Google Scholar 

GTEx Consortium. The GTEx consortium atlas of genetic regulatory effects across human tissues. Sci. 2020;369:1318–30.

Article  Google Scholar 

Gudjonsson A, Gudmundsdottir V, Axelsson GT, Gudmundsson EF, Jonsson BG, Launer LJ, et al. A genome-wide association study of serum proteins reveals shared loci with common diseases. Nat Commun. 2022;13:480.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Surendran P, Feofanova EV, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, et al. Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. Nat Genet. 2020;52:1314–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sakaue S, Kanai M, Tanigawa Y, Karjalainen J, Kurki M, Koshiba S, et al. A cross-population atlas of genetic associations for 220 human phenotypes. Nat Genet. 2021;53:1415–24.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dönertaş HM, Fabian DK, Valenzuela MF, Partridge L, Thornton JM. Common genetic associations between age-related diseases. Nat Aging. 2021;1:400–12.

Article  PubMed  PubMed Central  Google Scholar 

Li F, Wang Y, Hou X, Cao L, Zhou X, Yuan W, et al. Genetic predisposition to neurodegenerative diseases and risk of stroke: a negative randomization study. Front Neurosci. 2022;16:995045.

Article  PubMed  PubMed Central  Google Scholar 

Yin K-F, Chen T, Gu X-J, Su W-M, Jiang Z, Lu S-J, et al. Systematic druggable genome-wide mendelian randomization identifies therapeutic targets for sarcopenia. J Cachexia Sarcopenia Muscle. 2024;15:1324–34.

Article  PubMed  PubMed Central  Google Scholar 

Liu Q, Huang J, Ding H, Tao Y, Nan J, Xiao C, et al. Flavin-containing monooxygenase 2 confers cardioprotection in ischemia models through its disulfide bond catalytic activity. J Clin Invest. 2024;134:e177077.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhong S, Lan L, Wen Y. Evaluating the effect of childhood sunburn on the risk of cutaneous melanoma through mendelian randomization. Cancer Sci. 2023;114:4706–16.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin J, Zhou J, Xu Y. Potential drug targets for multiple sclerosis identified through mendelian randomization analysis. Brain: J Neurol. 2023;146:3364–72.

Article  Google Scholar 

Krohn L, Heilbron K, Blauwendraat C, Reynolds RH, Yu E, Senkevich K, et al. Genome-wide association study of REM sleep behavior disorder identifies polygenic risk and brain expression effects. Nat Commun. 2022;13:7496.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Buford TW, Manini TM, Kairalla JA, McDermott MM, Vaz Fragoso CA, Chen H, et al. Mitochondrial DNA sequence variants associated with blood pressure among 2 cohorts of older adults. J Am Heart Assoc. 2018;7:e010009.

Article  PubMed  PubMed Central  Google Scholar 

Wen H, Deng H, Li B, Chen J, Zhu J, Zhang X, et al. Mitochondrial diseases: from molecular mechanisms to therapeutic advances. Signal Transduct Target Ther. 2025;10:9.

Article  PubMed  PubMed Central  Google Scholar 

Shetty DK, Kalamkar KP, Inamdar MS. OCIAD1 controls electron transport chain complex I activity to regulate energy metabolism in human pluripotent stem cells. Stem Cell Rep. 2018;11:128–41.

Article  CAS  Google Scholar 

Kim S, Zingler M, Harrison JK, Scott EW, Cogle CR, Luo D, et al. Angiotensin II regulation of proliferation, differentiation, and engraftment of hematopoietic stem cells. Hypertens (dallas Tex,: 1979). 2016;67:574–84.

Article  CAS  Google Scholar 

Satou R, Gonzalez-Villalobos RA. JAK-STAT and the renin-angiotensin system: The role of the JAK-STAT pathway in blood pressure and intrarenal renin-angiotensin system regulation. Jak-stat. 2012;1:250–6.

Article  PubMed  PubMed Central  Google Scholar 

Xi W, Chen W, Sun W, Li X, Suo Z, Jiang G, et al. Mitochondrial activity regulates the differentiation of skin-derived mesenchymal stem cells into brown adipocytes to contribute to hypertension. Stem Cell Res Ther. 2021;12:167.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xiong Y, Huang J, Amoah AN, Liu B, Bo Y. Lyu Q. Folate, vitamin B6, and vitamin B12 intakes are negatively associated with the prevalence of hypertension: a national population-based study. Nutr Res. 2023;112:46–54.

Article  CAS  PubMed  Google Scholar 

Nikkari ST, Visto A-L, Määttä KM, Kunnas TA. Minor variant of rs 16827043 in the iron regulator hemojuvelin gene (HJV) contributes to hypertension: The TAMRISK study. Medicine. 2017;96:e6052.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Coppin H, Darnaud V, Kautz L, Meynard D, Aubry M, Mosser J, et al. Gene expression profiling of hfe-/- liver and duodenum in mouse strains with differing susceptibilities to iron loading: Identification of transcriptional regulatory targets of hfe and potential hemochromatosis modifiers. Genome Biol. 2007;8:R221.

Article  PubMed  PubMed Central  Google Scholar 

Keckesova Z, Donaher JL, De Cock J, Freinkman E, Lingrell S, Bachovchin DA, et al. LACTB is a tumour suppressor that modulates lipid metabolism and cell state. Nature. 2017;543:681–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang X, Ma L, Jiang S, Wen J, Yan Z, Tian L, et al. Expert consensus on prevention and treatment of aging-related gonadal dysfunction. Aging Dis. 2024;16:971–9.

PubMed  PubMed Central  Google Scholar 

Erdman RA, Shellenberger KE, Overmeyer JH, Maltese WA. Rab24 is an atypical member of the rab GTPase family. Deficient GTPase activity, GDP dissociation inhibitor interaction, and prenylation of Rab24 expressed in cultured cells. J Biol Chem. 2000;275:3848–56.

Comments (0)

No login
gif