Modeling the Distribution Kinetics of Charged Drugs in Tumor Cells under Variable Electric Fields Gradients on Mitochondrial and Nuclear Membranes

Dasari S., Tchounwou P.B. 2014. Cisplatin in cancer therapy: Molecular mechanisms of action. Eur. J. Pharmacol. 7 (21), 364–378. https://doi.org/10.1016/j.ejphar.2014.07.025

Article  CAS  Google Scholar 

Shikhlyarova A.I., Tarnopolskaya O.V., Shevchenko A.N., Kurkina T.A., Rezinkova I.A., Filatova E.V. 2013. Features of the accumulation of fluorochromes ANS, DSM, and doxorubicin in sarcoma cells of 45 rats when exposed to a magnetic field in vivo. Klinich. Experim. Morfologia. (Rus.). 3, 44–48.

Google Scholar 

Castano A.P., Demidova T.N., Hamblin M.R. 2005. Mechanisms in photodynamic therapy: Part three: Photo-sensitizer pharmacokinetics, bio-distribution, tumor localization and modes of tumor destruction. Photodiagn. Photodyn. Ther. 2 (2), 91–100. https://doi.org/10.1016/S1572-1000(05)00060-8

Article  CAS  Google Scholar 

Luo W., Liu R., Zhu J., Li Y., Liu H. 2014. Subcellular location and photodynamic Rong-Sen therapeutic effect of chlorin e6 in the human tongue squamous cell cancer Tca 8113 cell line. Oncol. Lett. 9 (2), 551–556. https://doi.org/10.3892/ol.2014.2720

Article  PubMed  PubMed Central  Google Scholar 

Zorina T.E., Yankovsky I.V., Yakovets I.V., Kravchenko I.E., Ermilova T.I., Shman T.V., Belev-tsev, M.V., Zorin V.P. 2019. Intracellular localization and phototoxicity mechanisms of chlorin e6 derivatives and their liposomal formulations. Biophysics. 64, 533–542. https://doi.org/10.1134/S0006350919040250

Article  CAS  Google Scholar 

Shirke A.A., Walker E., Chavali S., Ramamurthy G., Zhang L., Panigrahi A., Basilion J.P., Wang X. 2024. A synergistic strategy combining chemotherapy and photodynamic therapy to eradicate prostate cancer. Int. J. Mol. Sci. 25 (13), 70–86. https://doi.org/10.3390/ijms25137086

Article  CAS  Google Scholar 

Mikheeva N.A., Semenova M.A., Terentyuk G.S., Khairullin R.M., Mikheev O.V., Gal’chyn A.V. 2015. The gold nanoparticles' effect on mitochondrial potential and concentration of active oxygen of tumor cells in various periods of the cell cycle in vitro. Sovtemennye problemy nauki i obrazovania (Rus.). 4, 504.

Tarnopol'skaya O.V., Nepomnyashchaya E.M., Birbraev V.M., Tarbeeva M.L., Makarova E.I. 2014. Average membrane potential of tumor cells of five histotypes. Mezhdunarodnyi zhurnal prikladnykh I fundamentalnykh issledovanii (Rus.). 10, 108–109.

Yang M., Brackenbury W.J. 2013. Membrane potential and cancer progression. Front. Physiol. 4, 185. https://doi.org/10.3389/fphys.2013.00185

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kolobov A.V., Anashkina A.A., Gubernov V.V., Polezhaev A.A. 2009. Mathematical model of tumor growth taking into account the dichotomy of migration and proliferation. Comput. Res. Modeling. 1 (4), 415–422. https://doi.org/10.20537/2076-7633-2009-1-4-415-422

Article  Google Scholar 

Dobretsov G.E. 1989. Fluorescent probes in study of cells, membranes and lipoproteins. Moscow: Nauka.

Google Scholar 

Morozova G.I., Parkhomenko T.V., Klitsenko O.E., Thomson V.V. 2007. Stimulating effect of erythropoietin on thymocyte energetics established in vitro with a potential-sensitive fluorescent probe. Biochem. (Mosc.) Suppl. Series A, Membr. Cell Biol. 1 (4), 325–330. https://doi.org/10.1134/S1990747807040083

Article  Google Scholar 

Morozova G.I., Poletaev A.I., Borshchevskaya T.A. 1999. Inverted electrochemical potential on the nuclear membrane of cells and its association with cellular energy. In: Proceedings of the 2nd Congress of Russia Biophysicists. Moscow, p. 256–257.

Morozova G.I., Kornilaeva G.V., Podchernyaeva R.Y., Kulinich T.M, Bozhenko V.K. 2014. A study of the EHF-millimeter radiation influence on the membranes of T-lymphoblastoid cells in the culture with using fluorescent probe DSM. Biomeditsynskaya Radioelektronika (Rus.). 11, 31–38. https://doi.org/10.29039/rusjbpc.2023.0637

Article  Google Scholar 

Gennis R. 1997. Biomembrane molecular structure and function. Moscow: Mir.

Askarova K.Z., Morozova G.I., Anoshin A.A. 2019. Modeling the accumulation Kinetics of anionic photosensitizers in tumor cells with different transmembrane potentials. J. Mechanics of Continua and Mathematical Sciences. 1, 483–490. https://doi.org/10.26782/jmcms.2019.03.00048

Article  Google Scholar 

Zorina T.E., Yankovsky I.V., Zorin V.P. 2012. Intracellular localization and accumulation of esterified E6 derivatives. In: Mediko-biologicheskie osnovy zhizni (Medical and biological foundations of life). Minsk, p. 153–155.

Vereninov A.A., Malakhova I.I. 1986. Ion transport in cell culture. Leningrad: Mir.

Origin and OriginPro. https://www.originlab.com/index.aspx?go=Products/Origin Accessed June 30, 2025.

Tereshkina Yu.A., Kostryukova L.V., Tikhonova E.G., Khudoklinova Yu.Yu., Orlova N.A., Gisina A.M., Morozevich G.E., Melnikov P.A., Pokrovsky V.S. 2022. Chlorin e6 phospholipid delivery system featuring apn/cd13 targeting peptides: Cell death pathways, cell localization, in vivo biodistribution. Pharmaceutics. 14 (10), 1–15. https://doi.org/10.3390/pharmaceutics14102224

Article  CAS  Google Scholar 

Morozova G.I., Borisov V.A. 2015. Conjugate fluorescent effects of the photosensitizer chlorin and the cationic probe DSM in the native blood of cancer patients before and during PDT. In Proceedings of the 5fth Congress of Biophysicists of Russia. Rostov-on-Don. 2, 253.

Djamgoz M. 2024. Electrical excitability of cancer cells-CELEX model updated. Cancer Metastasis Rev. 3 (4), 1579–1591. https://doi.org/10.1007/s10555-024-10195-6

Article  CAS  Google Scholar 

Morozova G.I. 2013. Transmembrane potentials and mitochondrial activity of cells. In: Educational and methodical manual. Moscow: RUDN.

Google Scholar 

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