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Resistance of CD33+ Acute Myeloid Leukemia Cells to Anthracyclines in Three-Dimensional Cultures
Resistance of CD33+ Acute Myeloid Leukemia Cells to Anthracyclines in Three-Dimensional Cultures
Elucidating the mechanisms of drug resistance in acute myeloid leukemia (AML) cells is a critical endeavor in biomedicine ...
Activation of Pyruvate Dehydrogenase Complex with Inhibition of Krebs Cycle and Mitochondrial Respiration by the Excess of Pyruvate
Activation of Pyruvate Dehydrogenase Complex with Inhibition of Krebs Cycle and Mitochondrial Respiration by the Excess of Pyruvate
Experiments on isolated rat liver mitochondria have shown that pyruvate (10–30 mM) in the presence of L-glutamate ca...
Functional Role of Piezo1 Channels in Smooth Muscle Cells of Rat Cerebral Arteries under Normal Conditions and Chronic Carotid Artery Stenosis
Functional Role of Piezo1 Channels in Smooth Muscle Cells of Rat Cerebral Arteries under Normal Conditions and Chronic Carotid Artery Stenosis
In arterial smooth muscle cells, Piezo1 channels are involved in the regulation of vascular tone and remodeling in various...
The Effect of Extracellular Vesicles Produced by MMSC on the Growth Rate of Cultured Renal Epithelial Cells under Normal Conditions and under Oxygen-Glucose Deprivation
The Effect of Extracellular Vesicles Produced by MMSC on the Growth Rate of Cultured Renal Epithelial Cells under Normal Conditions and under Oxygen-Glucose Deprivation
This study characterizes extracellular vesicles (EVs) produced by multipotent mesenchymal stromal cells (MMSCs) in culture...
Activation of FLT3-Associated Signaling Pathways in Quizartinib-Resistant Macrophage-Like Cells of Acute Myeloid Leukemia
Activation of FLT3-Associated Signaling Pathways in Quizartinib-Resistant Macrophage-Like Cells of Acute Myeloid Leukemia
Investigating the mechanisms of resistance of acute myeloid leukemia (AML) cells to anticancer therapy, including targeted...
Decompensated Liver Cirrhosis Impairs the Deformability of Erythrocytes and Their Ability to Pass Through Microchannels
Decompensated Liver Cirrhosis Impairs the Deformability of Erythrocytes and Their Ability to Pass Through Microchannels
Red blood cells (RBC, erythrocytes) are the main cell population that ensures tissue oxygenation and forms the ordered mov...
The Potential for Using the Mechanism of Hypoxic Adaptation in Lower Eukaryotes
The Potential for Using the Mechanism of Hypoxic Adaptation in Lower Eukaryotes
This analytical review considers the main elements of mitochondrial restructuring that occurs in eukaryotes forced to live...
Morphological and Functional Evaluation of Rat Leg Muscles under the Influence of Hindlimb Unloading, Tenotomy, and Denervation
Morphological and Functional Evaluation of Rat Leg Muscles under the Influence of Hindlimb Unloading, Tenotomy, and Denervation
Skeletal muscle atrophy can develop under the influence of various factors associated with their disuse, such as immobiliz...
Nifedipine Attenuates Slow Myosin Expression in Rat Soleus Muscle after 3 Days of Hindlimb Unloading
Nifedipine Attenuates Slow Myosin Expression in Rat Soleus Muscle after 3 Days of Hindlimb Unloading
Early changes in the myosin genes expression pattern lead to slow-to-fast fiber type shift, functional and metabolic alter...
The Role of Lipid Rafts in the Regulation of Piezo1 Channels in C2C12 Myoblasts
The Role of Lipid Rafts in the Regulation of Piezo1 Channels in C2C12 Myoblasts
Piezo1 channels are mechanically activated (MA) cation channels that play an important role in skeletal muscle physiology....
X-Domain of nsp-3 Protein of the SARS-CoV-2 Coronavirus Is Capable of Deforming Membranes and Initiating of the Double-Membrane Vesicle Formation Depending on the Cholesterol Content
X-Domain of nsp-3 Protein of the SARS-CoV-2 Coronavirus Is Capable of Deforming Membranes and Initiating of the Double-Membrane Vesicle Formation Depending on the Cholesterol Content
Coronaviruses, including the pandemic SARS-CoV-2, encode 16 non-structural proteins that regulate various stages of virus ...
Signaling Effects of alpha-Ketoglutarate Precursor Administration in Rat Soleus Muscle under 7-Day Mechanical Unloading
Signaling Effects of alpha-Ketoglutarate Precursor Administration in Rat Soleus Muscle under 7-Day Mechanical Unloading
Under conditions of insufficient muscle activity (with their functional unloading), a number of pathological processes are...
The Effect of Na,K-ATPase and Dihydropyridine Receptor Activity on Ca Content and Contractile Properties of in Rats under Three-Day Functional Unloading
The Effect of Na,K-ATPase and Dihydropyridine Receptor Activity on Ca Content and Contractile Properties of in Rats under Three-Day Functional Unloading
Muscle atrophy and decreased strength are observed under hypokinesia; a decrease in strength can occur at the earliest sta...
Cells of Azulene-Containing Plants: Spectral Studies
Cells of Azulene-Containing Plants: Spectral Studies
The spectral study of the surface and isolated organelles of cells of azulene-containing plants of temperate climate, dry ...
Antioxidant Mito-TEMPO Partially Prevents Atrophy of the Rat Soleus Muscle after 7 Days of Functional Unloading
Antioxidant Mito-TEMPO Partially Prevents Atrophy of the Rat Soleus Muscle after 7 Days of Functional Unloading
Functional unloading of skeletal muscles is observed during space flight, prolonged bed rest, or limb immobilization. This...
The Role of Cx43 in the Survival and Death of Neurons and Glial Cells in Traumatic Injuries of the Central and Peripheral Nervous System
The Role of Cx43 in the Survival and Death of Neurons and Glial Cells in Traumatic Injuries of the Central and Peripheral Nervous System
Connexin 43 (Cx43) is a key protein in gap junctions, which play a dual role in regulating the survival and death of neuro...
The Effect of Pregnancy Specific Glycoprotein on the Presence of PD-L1 and CD73 Membrane Molecules on Myeloid-Derived Suppressor Cells and Their Cytokine Profile
The Effect of Pregnancy Specific Glycoprotein on the Presence of PD-L1 and CD73 Membrane Molecules on Myeloid-Derived Suppressor Cells and Their Cytokine Profile
Myeloid-derived suppressor cells (MDSC) play a key role in the formation of immune tolerance, including during pregnancy, ...
Transmembrane Proton Transfer in Chloroplasts : pH Homeostasis of Lumen, Stroma, and Cytosol
Transmembrane Proton Transfer in Chloroplasts : pH Homeostasis of Lumen, Stroma, and Cytosol
The research described in this paper is based on a mathematical model for the proton-dependent regulation of electron and ...
The Role of Nitric Oxide and Hydrogen Sulfide in Regulating the Expression of Pro- and Anti-Apoptotic Genes in Trauma to the Central and Peripheral Nervous System
The Role of Nitric Oxide and Hydrogen Sulfide in Regulating the Expression of Pro- and Anti-Apoptotic Genes in Trauma to the Central and Peripheral Nervous System
Injuries to the central and peripheral nervous systems are accompanied by complex cellular and molecular processes, includ...
Astaxanthin Prevents Hydrogen Peroxide Induced Decrease in the Viability of AC16 Cardiomyocytes
Astaxanthin Prevents Hydrogen Peroxide Induced Decrease in the Viability of AC16 Cardiomyocytes
The effect of astaxanthin (5 and 10 μM), a carotenoid xanthophyll, on the viability of human AC16 cardiomyocytes unde...
MKT-077 Suppresses the Functional Activity of Isolated Mouse Skeletal Muscle Mitochondria
MKT-077 Suppresses the Functional Activity of Isolated Mouse Skeletal Muscle Mitochondria
This study demonstrates the effect of the rhodocyanine derivative MKT-077 on the function of isolated mitochondria from mo...
Role of K and BK Channels in the Effects of Sodium Butyrate on Colon Motility in a Mouse Model of Irritable Bowel Syndrome
Role of K and BK Channels in the Effects of Sodium Butyrate on Colon Motility in a Mouse Model of Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is a multifactorial disorder, with a high socioeconomic impact, characterized by chronic ab...
Optimizing Oxygenic Photosynthesis: pH-Regulation of Electron Transport in Chloroplasts
Optimizing Oxygenic Photosynthesis: pH-Regulation of Electron Transport in Chloroplasts
The work is devoted to the mathematical modeling of the regulation of electron and proton transport in the thylakoid membr...
Network Pharmacology and Molecular Docking Analysis of Luteolin from for Drug Target Identification in Age-Related Cardiovascular Diseases
Network Pharmacology and Molecular Docking Analysis of Luteolin from for Drug Target Identification in Age-Related Cardiovascular Diseases
Aging is associated with an increased risk of cardiovascular diseases (CVDs), which are among the leading causes of mortal...
Effect of DHPR on Functional Properties, Energy, and Ca Metabolism of during Unloading
Effect of DHPR on Functional Properties, Energy, and Ca Metabolism of during Unloading
Dihydropyridine receptors (DHPR) participate in changes of the membrane potential during muscle unloading. We used nifedip...
Modeling the Structure of Myoglobin within the Abelian Higgs Model
Modeling the Structure of Myoglobin within the Abelian Higgs Model
The analysis of multi-atomic systems from the first principles is highly computationally intensive, therefore it requires ...
Kinetic Characteristics of Erythrocyte Membrane Acetylcholinesterase in Ground Squirrels During Hibernation and Arousal
Kinetic Characteristics of Erythrocyte Membrane Acetylcholinesterase in Ground Squirrels During Hibernation and Arousal
Hibernation of small mammals is unique in that it consists of bouts—alternating periods of deep hibernation and inte...
Tardigrade Dsup Protein Protects Human Cells during Proton Radiotherapy
Tardigrade Dsup Protein Protects Human Cells during Proton Radiotherapy
Principles of resistance to physicochemical stresses in extremophile organisms are unique for the development of new prote...
Receptor Histidine Kinases in Green Algae: Domain Analysis
Receptor Histidine Kinases in Green Algae: Domain Analysis
In bacteria and some eukaryotes, an important tool to respond to both external and internal signals is a two-component sys...
Changes of the Structure and Permeability of Lipid Membranes Caused by Nanoparticles and Pulsed Electromagnetic Effects
Changes of the Structure and Permeability of Lipid Membranes Caused by Nanoparticles and Pulsed Electromagnetic Effects
Studies of structure and permeability changes of biological and biomimetic lipid membranes caused by natural and artificia...
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