Aarsland D, Batzu L, Halliday GM, Geurtsen GJ, Ballard C, Ray Chaudhuri K, Weintraub D (2021) Parkinson disease-associated cognitive impairment. Nat Rev Dis Primers 7:47. https://doi.org/10.1038/s41572-021-00280-3

Article  PubMed  Google Scholar 

Almomani R, Verhagen JM, Herkert JC, Brosens E, van Spaendonck-Zwarts KY, Asimaki A, van der Zwaag PA, Frohn-Mulder IM, Bertoli-Avella AM, Boven LG, van Slegtenhorst MA, van der Smagt JJ, van Ijcken WF, Timmer B, van Stuijvenberg M, Verdijk RM, Saffitz JE, du Plessis FA, Michels M, Hofstra RM, Sinke RJ, van Tintelen JP, Wessels MW, Jongbloed JD, van de Laar IM (2016) Biallelic truncating mutations in ALPK3 cause severe pediatric cardiomyopathy. J Am Coll Cardiol 67:515–525. https://doi.org/10.1016/j.jacc.2015.10.093

Article  PubMed  CAS  Google Scholar 

Baronio D, Chen YC, Decker AR, Enckell L, Fernández-López B, Semenova S, Puttonen HAJ, Cornell RA, Panula P (2022) Vesicular monoamine transporter 2 (SLC18A2) regulates monoamine turnover and brain development in zebrafish. Acta Physiol (Oxf) 234:e13725. https://doi.org/10.1111/apha.13725

Article  PubMed  CAS  Google Scholar 

Castermans D, Volders K, Crepel A, Backx L, De Vos R, Freson K, Meulemans S, Vermeesch JR, Schrander-Stumpel CT, De Rijk P, Del-Favero J, Van Geet C, Van De Ven WJ, Steyaert JG, Devriendt K, Creemers JW (2010) SCAMP5, NBEA and AMISYN: three candidate genes for autism involved in secretion of large dense-core vesicles. Hum Mol Genet 19:1368–1378. https://doi.org/10.1093/hmg/ddq013

Article  PubMed  CAS  Google Scholar 

Connolly BS, Lang AE (2014) Pharmacological treatment of Parkinson disease: a review. JAMA 311:1670–1683. https://doi.org/10.1001/jama.2014.3654

Article  PubMed  CAS  Google Scholar 

Dauer W, Przedborski S (2003) Parkinson’s disease: mechanisms and models. Neuron 39:889–909. https://doi.org/10.1016/s0896-6273(03)00568-3

Article  PubMed  CAS  Google Scholar 

de Rijk MC, Launer LJ, Berger K, Breteler MM, Dartigues JF, Baldereschi M, Fratiglioni L, Lobo A, Martinez-Lage J, Trenkwalder C, Hofman A (2000) Prevalence of Parkinson’s disease in Europe: a collaborative study of population-based cohorts. Neurologic diseases in the elderly research group. Neurology 54:S21–S23

PubMed  Google Scholar 

Dhanasekaran DN, Reddy EP (2008) JNK signaling in apoptosis. Oncogene 27:6245–6251. https://doi.org/10.1038/onc.2008.301

Article  PubMed  PubMed Central  CAS  Google Scholar 

Doyle JM, Croll RP (2022) A critical review of Zebrafish models of Parkinson’s disease. Front Pharmacol 13:835827. https://doi.org/10.3389/fphar.2022.835827

Article  PubMed  PubMed Central  CAS  Google Scholar 

Du XY, Xie XX, Liu RT (2020) The role of α-synuclein oligomers in Parkinson’s disease. Int J Mol Sci. https://doi.org/10.3390/ijms21228645

Article  PubMed  PubMed Central  Google Scholar 

Fernández-Chacón R, Südhof TC (2000) Novel SCAMPs lacking NPF repeats: ubiquitous and synaptic vesicle-specific forms implicate SCAMPs in multiple membrane-trafficking functions. J Neurosci 20:7941–7950. https://doi.org/10.1523/jneurosci.20-21-07941.2000

Article  PubMed  PubMed Central  Google Scholar 

Fontana BD, Mezzomo NJ, Kalueff AV, Rosemberg DB (2018) The developing utility of zebrafish models of neurological and neuropsychiatric disorders: a critical review. Exp Neurol 299:157–171. https://doi.org/10.1016/j.expneurol.2017.10.004

Article  PubMed  Google Scholar 

Gaugler MN, Genc O, Bobela W, Mohanna S, Ardah MT, El-Agnaf OM, Cantoni M, Bensadoun JC, Schneggenburger R, Knott GW, Aebischer P, Schneider BL (2012) Nigrostriatal overabundance of α-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity. Acta Neuropathol 123:653–669. https://doi.org/10.1007/s00401-012-0963-y

Article  PubMed  CAS  Google Scholar 

Golbe LI (1991) Young-onset Parkinson’s disease: a clinical review. Neurology 41:168–173. https://doi.org/10.1212/wnl.41.2_part_1.168

Article  PubMed  CAS  Google Scholar 

Han C, Chen T, Yang M, Li N, Liu H, Cao X (2009) Human SCAMP5, a novel secretory carrier membrane protein, facilitates calcium-triggered cytokine secretion by interaction with SNARE machinery. J Immunol 182:2986–2996. https://doi.org/10.4049/jimmunol.0802002

Article  PubMed  CAS  Google Scholar 

Hu D, Sun X, Liao X, Zhang X, Zarabi S, Schimmer A, Hong Y, Ford C, Luo Y, Qi X (2019) Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity. Acta Neuropathol 137:939–960. https://doi.org/10.1007/s00401-019-01993-2

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ianakiev P, van Baren MJ, Daly MJ, Toledo SP, Cavalcanti MG, Neto JC, Silveira EL, Freire-Maia A, Heutink P, Kilpatrick MW, Tsipouras P (2001) Acheiropodia is caused by a genomic deletion in C7orf2, the human orthologue of the Lmbr1 gene. Am J Hum Genet 68:38–45. https://doi.org/10.1086/316955

Article  PubMed  CAS  Google Scholar 

Isaacson SH (2020) Effective treatment strategies for motor and nonmotor symptoms of Parkinson disease. J Clin Psychiatry. https://doi.org/10.4088/jcp.Ms18003br2c

Article  PubMed  Google Scholar 

Jia X, Chen Q, Yao C, Asakawa T, Zhang Y (2024) Α-synuclein regulates cyclin D1 to promote abnormal initiation of the cell cycle and induce apoptosis in dopamine neurons. Biomed Pharmacother 173:116444. https://doi.org/10.1016/j.biopha.2024.116444

Article  PubMed  CAS  Google Scholar 

Jiao X, Morleo M, Nigro V, Torella A, D’Arrigo S, Ciaccio C, Pantaleoni C, Gong P, Grand K, Sanchez-Lara PA, Krier J, Fieg E, Stergachis A, Wang X, Yang Z (2020) Identification of an identical de Novo SCAMP5 missense variant in four unrelated patients with seizures and severe neurodevelopmental delay. Front Pharmacol 11:599191. https://doi.org/10.3389/fphar.2020.599191

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kim EK, Choi EJ (2010) Pathological roles of MAPK signaling pathways in human diseases. Biochim Biophys Acta 1802:396–405. https://doi.org/10.1016/j.bbadis.2009.12.009

Article  PubMed  CAS  Google Scholar 

Lee U, Choi C, Ryu SH, Park D, Lee SE, Kim K, Kim Y, Chang S (2021a) SCAMP5 plays a critical role in axonal trafficking and synaptic localization of NHE6 to adjust quantal size at glutamatergic synapses. Proc Natl Acad Sci U S A. https://doi.org/10.1073/pnas.2011371118

Article  PubMed  PubMed Central  Google Scholar 

Lee U, Ryu SH, Chang S (2021b) SCAMP5 mediates activity-dependent enhancement of NHE6 recruitment to synaptic vesicles during synaptic plasticity. Mol Brain 14:47. https://doi.org/10.1186/s13041-021-00763-0

Article  PubMed  PubMed Central  CAS  Google Scholar 

Liao C, Cai B, Feng Y, Chen J, Wu Y, Zhuang J, Liu Z, Wu Y (2020) Activation of JNK signaling promotes all-trans-retinal-induced photoreceptor apoptosis in mice. J Biol Chem 295:6958–6971. https://doi.org/10.1074/jbc.RA120.013189

Article  PubMed  PubMed Central  CAS  Google Scholar 

Martelletti E, Ingham NJ, Houston O, Pass JC, Chen J, Marcotti W, Steel KP (2020) Synaptojanin2 mutation causes progressive high-frequency hearing loss in mice. Front Cell Neurosci 14:561857. https://doi.org/10.3389/fncel.2020.561857

Article  PubMed  PubMed Central  CAS  Google Scholar 

Martín-Jiménez R, Campanella M, Russell C (2015) New zebrafish models of neurodegeneration. Curr Neurol Neurosci Rep 15:33. https://doi.org/10.1007/s11910-015-0555-z

Article  PubMed  CAS  Google Scholar 

Milanese C, Sager JJ, Bai Q, Farrell TC, Cannon JR, Greenamyre JT, Burton EA (2012) Hypokinesia and reduced dopamine levels in zebrafish lacking β- and γ1-synucleins. J Biol Chem 287:2971–2983. https://doi.org/10.1074/jbc.M111.308312

Article  PubMed