World Health Organization (2023) WHO report on the global tobacco epidemic, 2023: protect people from tobacco smoke. World Health Organization, Geneva. Licence: CC BY-NC-SA 3.0 IGO

Bafunno D, Catino A, Lamorgese V, Del Bene G, Longo V, Montrone M, Pesola F, Pizzutilo P, Cassiano S, Mastrandrea A, Ricci D, Petrillo P, Varesano N, Zacheo A, Galetta D (2020) Impact of tobacco control interventions on smoking initiation, cessation, and prevalence: a systematic review. J Thorac Dis 12(7):3844–3856

Article  PubMed  PubMed Central  Google Scholar 

Barua RS, Rigotti NA, Benowitz NL, Cummings KM, Jazayeri MA, Morris PB, Ratchford EV, Sarna L, Stecker EC, Wiggins BS (2018) 2018 ACC expert consensus decision pathway on tobacco cessation treatment: a report of the American college of cardiology task force on clinical expert consensus documents. J Am Coll Cardiol 72(25):3332–3365

Article  PubMed  Google Scholar 

Auer R, Concha-Lozano N, Jacot-Sadowski I, Cornuz J, Berthet A (2017) Heat-not-burn tobacco cigarettes: smoke by any other name. JAMA Intern Med 177(7):1050–1052

Article  PubMed  PubMed Central  Google Scholar 

Andreozzi P, Gussoni G, Sesti G, Montano N, Pietrangelo A, Italian Society of Internal Medicine (SIMI) Council Member Group (2024) Impact of electronic cigarettes (e-cigs) and heat-not-burn/heated tobacco products (HnB/HTP) on asthma and chronic obstructive pulmonary disease: a viewpoint of the Italian Society of Internal Medicine. Intern Emerg Med 19(7):1829–1837

Article  PubMed  PubMed Central  Google Scholar 

Emma R, Caruso M, Campagna D, Pulvirenti R, Li Volti G (2022) The impact of tobacco cigarettes, vaping products and tobacco heating products on oxidative stress. Antioxidants (Basel) 11(9):1829

Article  PubMed  Google Scholar 

Bitzer ZT, Goel R, Trushin N, Muscat J, Richie JP Jr (2020) Free radical production and characterization of heat-not-burn cigarettes in comparison to conventional and electronic cigarettes. Chem Res Toxicol 33(7):1882–1887

Article  PubMed  PubMed Central  Google Scholar 

Lüdicke F, Haziza C, Weitkunat R, Magnette J (2016) Evaluation of biomarkers of exposure in smokers switching to a carbon-heated tobacco product: a controlled, randomized, open-label 5-day exposure study. Nicotine Tob Res 18(7):1606–1613. https://doi.org/10.1093/ntr/ntw022

Article  PubMed  PubMed Central  Google Scholar 

Lüdicke F, Baker G, Magnette J, Picavet P, Weitkunat R (2017) Reduced exposure to harmful and potentially harmful smoke constituents with the tobacco heating system 2.1. Nicotine Tob Res 19(2):168–175. https://doi.org/10.1093/ntr/ntw164

Article  PubMed  Google Scholar 

Haziza C, de La Bourdonnaye G, Merlet S, Benzimra M, Ancerewicz J, Donelli A, Baker G, Picavet P, Lüdicke F (2016) Assessment of the reduction in levels of exposure to harmful and potentially harmful constituents in Japanese subjects using a novel tobacco heating system compared with conventional cigarettes and smoking abstinence: a randomized controlled study in confinement. Regul Toxicol Pharmacol 81:489–499. https://doi.org/10.1016/j.yrtph.2016.09.014

Article  PubMed  Google Scholar 

Lüdicke F, Picavet P, Baker G, Haziza C, Poux V, Lama N, Weitkunat R (2018) Effects of switching to the tobacco heating system 2.2 menthol, smoking abstinence, or continued cigarette smoking on biomarkers of exposure: a randomized, controlled, open-label, multicenter study in sequential confinement and ambulatory settings (Part 1). Nicotine Tob Res 20(2):161–172. https://doi.org/10.1093/ntr/ntw287

Article  PubMed  Google Scholar 

Yuki D, Takeshige Y, Nakaya K, Futamura Y (2018) Assessment of the exposure to harmful and potentially harmful constituents in healthy Japanese smokers using a novel tobacco vapor product compared with conventional cigarettes and smoking abstinence. Regul Toxicol Pharmacol 96:127–134. https://doi.org/10.1016/j.yrtph.2018.05.001

Article  PubMed  Google Scholar 

Gale N, McEwan M, Eldridge AC, Fearon IM, Sherwood N, Bowen E, McDermott S, Holmes E, Hedge A, Hossack S, Wakenshaw L, Glew J, Camacho OM, Errington G, McAughey J, Murphy J, Liu C, Proctor CJ (2019) Changes in biomarkers of exposure on switching from a conventional cigarette to tobacco heating products: a randomized, controlled study in healthy Japanese subjects. Nicotine Tob Res 21(9):1220–1227. https://doi.org/10.1093/ntr/nty104

Article  PubMed  Google Scholar 

Haziza C, de La Bourdonnaye G, Donelli A, Poux V, Skiada D, Weitkunat R, Baker G, Picavet P, Lüdicke F (2020) Reduction in exposure to selected harmful and potentially harmful constituents approaching those observed upon smoking abstinence in smokers switching to the menthol tobacco heating system 2.2 for 3 months (Part 1). Nicotine Tob Res 22(4):539–548. https://doi.org/10.1093/ntr/ntz013

Article  PubMed  Google Scholar 

Tran CT, Bosilkovska M, de La Bourdonnaye G, Blanc N, Haziza C (2020) Reduced levels of biomarkers of exposure in smokers switching to the carbon-heated tobacco product 1.0: a controlled, randomized, open-label 5-day exposure trial. Sci Rep 10(1):19227. https://doi.org/10.1038/s41598-020-76222-y

Article  PubMed  PubMed Central  Google Scholar 

Gale N, McEwan M, Camacho OM, Hardie G, Murphy J, Proctor CJ (2021) Changes in biomarkers of exposure on switching from a conventional cigarette to the glo tobacco heating product: a randomized, controlled ambulatory study. Nicotine Tob Res 23(3):584–591. https://doi.org/10.1093/ntr/ntaa135

Article  PubMed  Google Scholar 

McEwan M, Gale N, Ebajemito JK, Camacho OM, Hardie G, Proctor CJ, Murphy J (2021) A randomized controlled study in healthy participants to explore the exposure continuum when smokers switch to a tobacco heating product or an e-cigarette relative to cessation. Toxicol Rep 8:994–1001. https://doi.org/10.1016/j.toxrep.2021.05.003

Article  PubMed  PubMed Central  Google Scholar 

Gale N, McEwan M, Camacho OM, Hardie G, Proctor CJ, Murphy J (2021) Changes in biomarkers after 180 days of tobacco heating product use: a randomised trial. Intern Emerg Med 16(8):2201–2212. https://doi.org/10.1007/s11739-021-02798-6

Article  PubMed  PubMed Central  Google Scholar 

Gale N, McEwan M, Hardie G, Proctor CJ, Murphy J (2022) Changes in biomarkers of exposure and biomarkers of potential harm after 360 days in smokers who either continue to smoke, switch to a tobacco heating product or quit smoking. Intern Emerg Med 17(7):2017–2030. https://doi.org/10.1007/s11739-022-03062-1

Article  PubMed  PubMed Central  Google Scholar 

Chu S, Li X, Zhang D, Jing H, Feng L, Zuo Y, Li J, Ma H, Tong Z, Liang L (2025) Impact of heating conventional cigarettes with a novel device on health-related biomarkers and cigarette use patterns among Chinese adult smokers unwilling to quit: a pilot randomized controlled trial. Nicotine Tob Res 27(5):873–883. https://doi.org/10.1093/ntr/ntae177

Article  PubMed  Google Scholar 

Ansari SM, Leroy P, de La Bourdonnaye G, Pouly S, Reese L, Haziza C (2025) Differences in biomarkers of potential harm after 2+ years of tobacco heating system use compared to cigarette smoking: a cross-sectional study. Biomarkers 30(2):178–191. https://doi.org/10.1080/1354750X.2024.2430257

Article  PubMed  Google Scholar 

Tattan-Birch H, Hartmann-Boyce J, Kock L, Simonavicius E, Brose L, Jackson S, Shahab L, Brown J (2022) Heated tobacco products for smoking cessation and reducing smoking prevalence. Cochrane Database Syst Rev 1(1):CD013790. https://doi.org/10.1002/14651858.CD013790.pub2

Article  PubMed  Google Scholar 

Znyk M, Jurewicz J, Kaleta D (2021) Exposure to heated tobacco products and adverse health effects: a systematic review. Int J Environ Res Public Health 18(12):6651. https://doi.org/10.3390/ijerph18126651

Article  PubMed  PubMed Central  Google Scholar 

Sun T, Anandan A, Lim CCW, East K, Xu SS, Quah ACK, Rutherford BN, Johnson B, Qi Y, Stjepanovic D, Leung J, Connor JP, Gartner C, Hall WD, Vu G, Chan GCK (2023) Global prevalence of heated tobacco product use, 2015–22: a systematic review and meta-analysis. Addiction 118(8):1430–1444. https://doi.org/10.1111/add.16159

Article  PubMed  Google Scholar 

Nakama C, Tabuchi T (2021) Use of heated tobacco products by people with chronic diseases: the 2019 JASTIS study. PLoS ONE 16(11):e0260154. https://doi.org/10.1371/journal.pone.0260154

Article  PubMed  PubMed Central  Google Scholar 

Loffredo L, Carnevale R, Battaglia S, Marti R, Pizzolo S, Bartimoccia S, Nocella C, Cammisotto V, Sciarretta S, Chimenti I, De Falco E, Cavarretta E, Peruzzi M, Marullo A, Miraldi F, Violi F, Morelli A, Biondi-Zoccai G, Frati G (2021) Impact of chronic use of heat-not-burn cigarettes on oxidative stress, endothelial dysfunction and platelet activation: the SUR-VAPES chronic study. Thorax 76(6):618–620. https://doi.org/10.1136/thoraxjnl-2020-216253

Article  PubMed  Google Scholar 

Schirone L, Loffredo L, Carnevale R, Battaglia S, Marti R, Pizzolo S, Bartimoccia S, Nocella C, Cammisotto V, Saade W, Tanzilli A, Sciarretta S, Chimenti I, De Falco E, Cavarretta E, Picchio V, Peruzzi M, Marullo A, Miraldi F, Violi F, Morelli A, Biondi-Zoccai G, Frati G (2022) Sex-related differences in oxidative, platelet, and vascular function in chronic users of heat-not-burn vs conventional combustion cigarettes. Antioxidants (Basel) 11(7):1237. https://doi.org/10.3390/antiox11071237

Article  PubMed  Google Scholar 

Lüdicke F, Ansari SM, Lama N, Blanc N, Bosilkovska M, Donelli A, Picavet P, Baker G, Haziza C, Peitsch M, Weitkunat R (2019) Effects of switching to a heat-not-burn tobacco product on biologically relevant biomarkers to assess a candidate modified risk tobacco product: a randomized trial. Cancer Epidemiol Biomarkers Prev 28(11):1934–1943. https://doi.org/10.1158/1055-9965.EPI-19-0278

Article  PubMed