Calcified chondroid mesenchymal neoplasm

FN1 gene rearrangements have previously been described in subsets of calcifying / chondroid matrix-producing soft tissue tumors including synovial chondromatosis, phosphaturic mesenchymal tumor, and calcifying aponeurotic fibroma.1, 2, 3 In 2021, Liu and colleagues introduced a new category of matrix-forming lesions with FN1 rearrangements termed ‘calcified chondroid mesenchymal neoplasm (CCMN)’.4 These tumors contain plump epithelioid cells, multinucleated giant cells, and variable matrix which has historically led to confusion with other entities such as soft tissue chondroma, chondroblastoma and tenosynovial giant cell tumor. Although CCMN is an evolving entity, it appears there are three subtypes based on the type and distribution of matrix/calcification, which include chondroblastoma-like soft tissue chondroma, tophaceous pseudogout, chondroid synoviocytic neoplasm.

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