Evolving Evidence in Solid Organ Transplantation for People with HIV: Rejection, Infection, and the Expanding Role of Donors with HIV

Trickey A, Sabin CA, Burkholder G, Crane H, D’Arminio Monforte A, Egger M, et al. Life expectancy after 2015 of adults with HIV on long-term antiretroviral therapy in Europe and North America: a collaborative analysis of cohort studies. Lancet HIV. 2023;10(5):e295–307. https://doi.org/10.1016/s2352-3018(23)00028-0.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Althoff KN, Stewart C, Humes E, Gerace L, Boyd C, Gebo K, et al. The forecasted prevalence of comorbidities and multimorbidity in people with HIV in the United States through the year 2030: A modeling study. PLoS Med. 2024;21(1):e1004325. https://doi.org/10.1371/journal.pmed.1004325.

Article  PubMed  PubMed Central  Google Scholar 

Locke JE, Gustafson S, Mehta S, Reed RD, Shelton B, MacLennan PA, et al. Survival Benefit of Kidney Transplantation in HIV-infected Patients. Ann Surg. 2017;265(3):604–8. https://doi.org/10.1097/SLA.0000000000001761.

Article  PubMed  PubMed Central  Google Scholar 

Roland ME, Barin B, Huprikar S, Murphy B, Hanto DW, Blumberg E, et al. Survival in HIV-positive transplant recipients compared with transplant candidates and with HIV-negative controls. AIDS. 2016;30(3):435–44. https://doi.org/10.1097/QAD.0000000000000934.

Article  PubMed  PubMed Central  Google Scholar 

Van Lunzen J, Maggiolo F, Arribas JR, Rakhmanova A, Yeni P, Young B, et al. Once daily dolutegravir (S/GSK1349572) in combination therapy in antiretroviral-naive adults with HIV: planned interim 48 week results from SPRING-1, a dose-ranging, randomised, phase 2b trial. Lancet Infect Dis. 2012;12(2):111–8. https://doi.org/10.1016/s1473-3099(11)70290-0.

Article  PubMed  Google Scholar 

Spinelli MA, Hessol NA, Schwarcz SK, Scheer S, Gandhi M, Chin Hsu L. Disparities in integrase inhibitor usage in the modern HIV treatment era: A Population-based study in a US city. Open Forum Infect Dis. 2021;8(7). https://doi.org/10.1093/ofid/ofab139.

Gathogo E, Harber M, Bhagani S, Levy J, Jones R, Hilton R, et al. Impact of Tacrolimus Compared With Cyclosporin on the Incidence of Acute Allograft Rejection in Human Immunodeficiency Virus-Positive Kidney Transplant Recipients. Transplantation. 2016;100(4):871–8. https://doi.org/10.1097/TP.0000000000000879.

Article  CAS  PubMed  Google Scholar 

Kucirka LM, Durand CM, Bae S, Avery RK, Locke JE, Orandi BJ, et al. Induction immunosuppression and clinical outcomes in kidney transplant recipients infected with human immunodeficiency virus. Am J Transplant. 2016;16(8):2368–76. https://doi.org/10.1111/ajt.13840.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Health NIo. Final human immunodeficiency virus (HIV) Organ Policy Equity (HOPE) Act safeguards and research criteria for transplantation of organs infected with HIV. Fed Reg. 2015;80(227):73785–95.

Google Scholar 

Durand CM, Massie A, Florman S, Liang T, Rana MM, Friedman-Moraco R, et al. Safety of Kidney Transplantation from Donors with HIV. N Engl J Med. 2024;391(15):1390–401. https://doi.org/10.1056/NEJMoa2403733.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Durand CM, Zhang W, Brown DM, Yu S, Desai N, Redd AD, et al. A prospective multicenter pilot study of HIV-positive deceased donor to HIV-positive recipient kidney transplantation: HOPE in action. Am J Transplant. 2021;21(5):1754–64. https://doi.org/10.1111/ajt.16205.

Article  PubMed  Google Scholar 

Health USDo, Services H. Organ Procurement and Transplantation: Implementation of the HIV Organ Policy Equity (HOPE) Act. Office of the Federal Register, National Archives and Records Administration. 2024;6150–67.

Department of Health and Human Services. Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV. 2024.

Althoff KN, Gebo KA, Moore RD, Boyd CM, Justice AC, Wong C, et al. Contributions of traditional and HIV-related risk factors on non-AIDS-defining cancer, myocardial infarction, and end-stage liver and renal diseases in adults with HIV in the USA and Canada: a collaboration of cohort studies. Lancet HIV. 2019;6(2):e93–104. https://doi.org/10.1016/s2352-3018(18)30295-9.

Article  PubMed  PubMed Central  Google Scholar 

Swanepoel CR, Atta MG, D’Agati VD, Estrella MM, Fogo AB, Naicker S, et al. Kidney disease in the setting of HIV infection: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int. 2018;93(3):545–59. https://doi.org/10.1016/j.kint.2017.11.007.

Article  PubMed  PubMed Central  Google Scholar 

Smith CJ, Ryom L, Weber R, Morlat P, Pradier C, Reiss P, et al. Trends in underlying causes of death in people with HIV from 1999 to 2011 (D:A:D): a multicohort collaboration. Lancet. 2014;384(9939):241–8. https://doi.org/10.1016/S0140-6736(14)60604-8.

Article  PubMed  Google Scholar 

Bica I, McGovern B, Dhar R, Stone D, McGowan K, Scheib R, et al. Increasing mortality due to end-stage liver disease in patients with human immunodeficiency virus infection. Clin Infect Dis. 2001;32(3):492–7. https://doi.org/10.1086/318501.

Article  CAS  PubMed  Google Scholar 

Campos-Varela I, Dodge JL, Berenguer M, Adam R, Samuel D, Di Benedetto F, et al. Temporal trends and outcomes in liver transplantation for recipients with HIV infection in europe and united states. Transplantation. 2020;104(10):2078–86. https://doi.org/10.1097/TP.0000000000003107.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Campos-Varela I, Dodge JL, Terrault NA, Brandman D, Price JC. Nonviral liver disease is the leading indication for liver transplant in the United States in persons living with human immunodeficiency virus. Am J Transplant. 2021;21(9):3148–56. https://doi.org/10.1111/ajt.16569.

Article  PubMed  PubMed Central  Google Scholar 

Lake JE, Overton T, Naggie S, Sulkowski M, Loomba R, Kleiner DE, et al. Expert panel review on nonalcoholic fatty liver disease in persons with human immunodeficiency virus. Clin Gastroenterol Hepatol. 2022;20(2):256–68. https://doi.org/10.1016/j.cgh.2020.10.018.

Article  CAS  PubMed  Google Scholar 

Lake JE, Taron J, Ribaudo HJ, Leon-Cruz J, Utay NS, Swaminathan S, et al. Hepatic steatosis and nonalcoholic fatty liver disease are common and associated with cardiometabolic risk in a primary prevention cohort of people with HIV. AIDS. 2023;37(14):2149–59. https://doi.org/10.1097/QAD.0000000000003671.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shah ASV, Stelzle D, Lee KK, Beck EJ, Alam S, Clifford S, et al. Global Burden of Atherosclerotic Cardiovascular Disease in People Living With HIV: Systematic Review and Meta-Analysis. Circulation. 2018;138(11):1100–12. https://doi.org/10.1161/CIRCULATIONAHA.117.033369.

Article  PubMed  PubMed Central  Google Scholar 

Chen Y, Gao Y, Zhou Y, Li X, Wang H, Polonsky TS, et al. Human Immunodeficiency Virus Infection and Incident Heart Failure: A Meta-Analysis of Prospective Studies. J Acquir Immune Defic Syndr. 2021;87(1):741–9. https://doi.org/10.1097/QAI.0000000000002629.

Article  PubMed  PubMed Central  Google Scholar 

Go AS, Reynolds K, Avula HR, Towner WJ, Hechter RC, Horberg MA et al. Human immunodeficiency virus infection and variation in heart failure risk by age, sex, and ethnicity: the HIV HEART study. Mayo Clin Proc. 2022;97(3):465 – 79. https://doi.org/10.1016/j.mayocp.2021.10.004

Konstantinidis I, Crothers K, Kunisaki KM, Drummond MB, Benfield T, Zar HJ, et al. HIV-associated lung disease. Nat Rev Dis Primers. 2023;9(1):39. https://doi.org/10.1038/s41572-023-00450-5.

Article  PubMed  PubMed Central  Google Scholar 

Asfar T, Perez A, Shipman P, Carrico AW, Lee DJ, Alcaide ML, et al. National Estimates of Prevalence, Time-Trend, and Correlates of Smoking in US People Living with HIV (NHANES 1999–2016). Nicotine Tob Res. 2021;23(8):1308–17. https://doi.org/10.1093/ntr/ntaa277.

Article  PubMed  PubMed Central  Google Scholar 

Bigna JJ, Kenne AM, Asangbeh SL, Sibetcheu AT. Prevalence of chronic obstructive pulmonary disease in the global population with HIV: a systematic review and meta-analysis. Lancet Glob Health. 2018;6(2):e193–202. https://doi.org/10.1016/S2214-109X(17)30451-5.

Article  PubMed  Google Scholar 

Locke JE, Durand C, Reed RD, MacLennan PA, Mehta S, Massie A, et al. Long-term Outcomes After Liver Transplantation Among Human Immunodeficiency Virus-Infected Recipients. Transplantation. 2016;100(1):141–6. https://doi.org/10.1097/TP.0000000000000829.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zarinsefat A, Gulati A, Shui A, Braun H, Rogers R, Hirose R, et al. Long-term Outcomes Following Kidney and Liver Transplant in Recipients With HIV. JAMA Surg. 2022;157(3):240–7. https://doi.org/10.1001/jamasurg.2021.6798.

Article  PubMed  PubMed Central  Google Scholar 

Apewokin S, Madan R, Restrepo A, Hemmige VS, Arora S. Clinical and health care utilization outcomes of kidney transplantation in HIV-positive recipients: A nationwide analysis from 2008–2013. Transplant Proc. 2018;50(10):3361-6. https://doi.org/10.1016/j.transproceed.2018.08.002

Cooper M, Dunne I, Kuten S, Curtis A, Graviss EA, Nguyen DT, et al. Impact of Proteas

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