Clinical Staging, Histopathological Features and Treatment Outcomes in Malignant Melanoma: A 10-Year Retrospective Single-Center Study

This study included 95 patients, comprising 50 males (52.6%) and 45 females (47.4%), with a mean age of 56.9±16.4 years (range: 24-90). Detailed demographic characteristics are presented in Table 7.

Characteristics Number of Patients Percentage (%) Sex Male 50 52,6 Sex Female 45 47,4 Melanoma Type Skin 73 76,8 Melanoma Type Mucosal 8 8,4 Melanoma Type Ocular 9 9,4 Melanoma Type Unknown 5 5,2 Localization Ocular 9 9,5 Localization Skin 11 11,6 Localization Head and Neck 21 22,1 Localization Trunk 9 9,5 Localization Lower Extremity 9 9,5 Localization Upper Extremity 23 24,2 Localization Mucosal 5 5,3 Localization Oral Mucosa 1 1,1 Localization Rectum 2 2,1 Localization Unknown 5 5,3 Type of Surgery Tumor Excision 58 86,6 Type of Surgery Enucleation 9 13,4 Lymph Node Involvement N0 47 78,3 Lymph Node Involvement N1 2 3,3 Lymph Node Involvement N2 2 3,3 Lymph Node Involvement N3 9 15 Metastasis Absent 50 79,4 Metastasis Present 13 20,6 At Diagnosis Metastasis Liver 12 34,2 At Diagnosis Metastasis Brain 5 14,2 At Diagnosis Metastasis Skin 2 5,7 At Diagnosis Metastasis Lung 10 28,5 At Diagnosis Metastasis Abdomen 6 17,1 During Follow-up Metastasis Liver 4 12,9 During Follow-up Metastasis Brain 7 22,6 During Follow-up Metastasis Abdomen 14 45,2 During Follow-up Metastasis Lung 6 19,4 MaleCOG 0 40 42,1 1 36 37,9 2 15 15,8 3 4 4,2 Final Status Malex 34 35,8 Alive 61 64,2 Table 7:
Patient and Clinical Characteristics.

Melanoma Subtypes and Localization Cutaneous melanoma was the most common subtype (81.1%, n=73), followed by ocular (10.0%, n=9) and mucosal melanoma (8.9%, n=8). In five patients, the primary tumor site could not be identified. Nodular melanoma was the most prevalent histological subtype (46.7%, n=28), followed by lentigo maligna (21.7%, n=13), superficial spreading melanoma (13.3%, n=8) and acral lentiginous melanoma (13.3%, n=8). Information on histological subtype was missing in 35 cases. The extremities were the most frequent tumor location (33.7%, n=32), with the lower limbs accounting for 71.8% of these cases, followed by the head and neck region (22.1%) and the trunk (9.5%).

Comments (0)

No login
gif