Pragmatic Strategies for Reducing Variability and Risk in Food Oral Immunotherapy

Sicherer SH, Sampson HA (2018) Food allergy: a review and update on epidemiology, pathogenesis, diagnosis, prevention, and management. J Allergy Clin Immunol 141:41–58

Article  CAS  PubMed  Google Scholar 

Sicherer SH, Munoz-Furlong A, Godbold JH, Sampson HA (2010) US prevalence of self-reported peanut, tree nut, and sesame allergy: 11-year follow-up. J Allergy Clin Immunol 125:1322–1326

Article  CAS  PubMed  Google Scholar 

Warren C, Lei D, Sicherer S, Schleimer R, Gupta R (2021) Prevalence and characteristics of peanut allergy in US adults. J Allergy Clin Immunol 147:2263–70e5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lange L, Klimek L, Beyer K, Blumchen K, Novak N, Hamelmann E et al (2021) White paper on peanut allergy - part 1: Epidemiology, burden of disease, health economic aspects. Allergo J Int 30:261–269

Article  PubMed  PubMed Central  Google Scholar 

Chu DK, Wood RA, French S, Fiocchi A, Jordana M, Waserman S et al (2019) Oral immunotherapy for peanut allergy (PACE): a systematic review and meta-analysis of efficacy and safety. Lancet 393:2222–2232

Article  CAS  PubMed  Google Scholar 

Vickery BP, Vereda A, Casale TB, Beyer K, du Toit G et al (2018) AR101 Oral immunotherapy for peanut allergy. N Engl J Med 379:1991–2001

Article  PubMed  Google Scholar 

Jones SM, Kim EH, Nadeau KC, Nowak-Wegrzyn A, Wood RA, Sampson HA et al (2022) Efficacy and safety of oral immunotherapy in children aged 1–3 years with peanut allergy (the Immune Tolerance Network IMPACT trial): a randomised placebo-controlled study. Lancet 399:359–371

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim EH, Bird JA, Keet CA, Virkud YV, Herlihy L, Ye P et al (2024) Desensitization and remission after peanut sublingual immunotherapy in 1- to 4-year-old peanut-allergic children: A randomized, placebo-controlled trial. J Allergy Clin Immunol 153:173–181e10

Article  CAS  PubMed  Google Scholar 

Du Toit G, Brown KR, Vereda A, Irani AM, Tilles S, Ratnayake A et al (2023) Oral immunotherapy for peanut allergy in children 1 to less than 4 years of age. NEJM Evid 2:EVIDoa2300145

Article  PubMed  Google Scholar 

Hunter H, Ue KL, Cornelius V, Yung CC, Thomas I, Tsilochristou O et al (2025) Oral immunotherapy in peanut-allergic adults using real-world materials. Allergy 80:2310–2318

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sicherer SH, Bunyavanich S, Berin MC, Lo T, Groetch M, Schaible A et al (2025) Peanut oral immunotherapy in children with high-threshold peanut allergy. NEJM Evid 4:EVIDoa2400306

Article  PubMed  Google Scholar 

Gard CN, Sanders GM, Slack IF, Schuler CFt, Freigeh GE, O’Shea KM (2025) Peanut challenges prior to oral immunotherapy demonstrate high tolerance rates in selected patients. J Allergy Clin Immunol Glob 4:100442

Article  PubMed  PubMed Central  Google Scholar 

Smith SA, Khan YW, Shrem RA, Hemler JA, Doyle JE, Daniel J et al (2025) Antigenic determinants underlying IgE-mediated anaphylaxis to peanut. J Allergy Clin Immunol 155:1595–606e10

Article  CAS  PubMed  Google Scholar 

Hise K, Rabin RL (2020) Oral immunotherapy for food allergy-a us regulatory perspective. Curr Allergy Asthma Rep 20:77

Article  PubMed  Google Scholar 

Casale TB, Stone CA Jr., Chapman MD, Tilles SA, Irani AM, Sanchez-Lopez J et al (2025) Comparison of an FDA-approved peanut oral immunotherapy product with peanut food products. J Allergy Clin Immunol 156:1420–1423

Article  CAS  PubMed  Google Scholar 

Jara M, Walker E, Tilles S, Anagnostou A (2024) Real-world safety experience with Peanut (Arachis hypogaea) Allergen Powder-dnfp in 2500 children with peanut allergy. Ann Allergy Asthma Immunol 132:778–780

Article  PubMed  Google Scholar 

Bird JA, Nilsson C, Brown K, Pham T, Tilles S, du Toit G et al (2023) Long-term safety and immunologic outcomes of daily oral immunotherapy for peanut allergy. J Allergy Clin Immunol Glob 2:100120

Article  PubMed  PubMed Central  Google Scholar 

Wasserman RL, Hague AR, Pence DM, Sugerman RW, Silvers SK, Rolen JG et al (2019) Real-world experience with peanut oral immunotherapy: lessons learned from 270 patients. J Allergy Clin Immunol Pract 7:418–26e4

Article  PubMed  Google Scholar 

Filep S, Chapman MD (2022) Doses of specific allergens in early introduction foods for prevention of food allergy. J Allergy Clin Immunol Pract 10:150–8e3

Article  CAS  PubMed  Google Scholar 

Mack DP, Foster GA, Mack JD, Mack LC, Hanna MA (2021) Weighing peanut candies used for oral immunotherapy mitigates variable peanut protein dose. J Allergy Clin Immunol Pract 9:521–3e1

Article  CAS  PubMed  Google Scholar 

Filep SC, Tilles S, Chapman MD (2025) Allergen deficiencies in a commonly used protocol for peanut oral immunotherapy. J Allergy Clin Immunol 156:1424–1426

Article  CAS  PubMed  Google Scholar 

Verhoeckx KCM, Vissers YM, Baumert JL, Faludi R, Feys M, Flanagan S et al (2015) Food processing and allergenicity. Food Chem Toxicol 80:223–240

Article  CAS  PubMed  Google Scholar 

Maleki SJ, Chung SY, Champagne ET, Raufman JP (2000) The effects of roasting on the allergenic properties of peanut proteins. J Allergy Clin Immunol 106:763–768

Article  CAS  PubMed  Google Scholar 

Pomes A, Butts CL, Chapman MD (2006) Quantification of Ara h 1 in peanuts: why roasting makes a difference. Clin Exp Allergy 36:824–830

Article  CAS  PubMed  Google Scholar 

Filep S, Block DS, Smith BRE, King EM, Commins S, Kulis M et al (2018) Specific allergen profiles of peanut foods and diagnostic or therapeutic allergenic products. J Allergy Clin Immunol 141:626–31e7

Article  CAS  PubMed  Google Scholar 

Wasserman RL, Jones DH, Windom HH, Meeting F (2019) Reaching for best practices in food oral immunotherapy: report on the second annual food allergy support team meeting. Ann Allergy Asthma Immunol 123:129–30e3

Leonard SA, Ogawa Y, Jedrzejewski PT, Maleki SJ, Chapman MD, Tilles SA et al (2022) Manufacturing processes of peanut (Arachis hypogaea) allergen powder-dnfp. Front Allergy 3:1004056

Article  PubMed  PubMed Central  Google Scholar 

Kim EH, Carr WW, Assa’ad AH, Gogate SU, Petroni DH, Casale TB et al (2025) ADP101 multifood oral immunotherapy for food-allergic patients: harmony phase 1/2 randomized clinical trial. J Allergy Clin Immunol Glob 4:100382

Article  PubMed  Google Scholar 

Blaiss MS, Tilles S, Petroni D, Zigmont E, Cassese M, Kwak B et al (2019) Current management and use of oral immunotherapy in the United States for patients with peanut allergy. Allergy Asthma Proc 40:214–220

Article  CAS  PubMed  Google Scholar 

Begin P, Chan ES, Kim H, Wagner M, Cellier MS, Favron-Godbout C et al (2020) CSACI guidelines for the ethical, evidence-based and patient-oriented clinical practice of oral immunotherapy in IgE-mediated food allergy. Allergy Asthma Clin Immunol 16:20

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wasserman RL, Factor J, Windom HH, Abrams EM, Begin P, Chan ES et al (2021) An approach to the office-based practice of food oral immunotherapy. J Allergy Clin Immunol Pract 9:1826–38e8

Article  PubMed  Google Scholar 

Wasserman RL, Jones DH, Windom HH (2018) Oral immunotherapy for food allergy: The FAST perspective. Ann Allergy Asthma Immunol 121:272–275

Article  PubMed 

Comments (0)

No login
gif