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A Comprehensive Review of IL-10 and IL-10 Receptor Deficiencies: From Basic Science to Clinical Bedside
A Comprehensive Review of IL-10 and IL-10 Receptor Deficiencies: From Basic Science to Clinical Bedside
Interleukin 10 (IL-10) is a potent anti-inflammatory cytokine. IL-10 receptor (IL-10R) consists of two chains of ligand-bi...
Therapeutic Potential of Tulisokibart and Anti-TL1A Therapy in Inflammatory Disorders: Current Insights and Future Directions
Therapeutic Potential of Tulisokibart and Anti-TL1A Therapy in Inflammatory Disorders: Current Insights and Future Directions
Tumor necrosis factor-like cytokine 1 A (TL1A), encoded by the TNFSF15 gene, is expressed on multiple cells, incl...
The Self-amplifying Inflammatory Cascade in Obstetric Antiphospholipid Syndrome: From Pathophysiology to Placenta-centric Immunotherapeutic Targets
The Self-amplifying Inflammatory Cascade in Obstetric Antiphospholipid Syndrome: From Pathophysiology to Placenta-centric Immunotherapeutic Targets
Obstetric Antiphospholipid Syndrome (OAPS) is an autoimmune-driven pregnancy complication whose core pathology is a dysreg...
Advances in Biomarkers and Therapeutic Targets for Idiopathic Inflammatory Myopathies Related Lung Disease
Advances in Biomarkers and Therapeutic Targets for Idiopathic Inflammatory Myopathies Related Lung Disease
In adults with idiopathic inflammatory myopathies (IIM), interstitial lung disease (ILD) is a common and severe complicati...
Management and Immunotherapy for Fungal Allergy: Clinical Practice and Unmet Needs
Management and Immunotherapy for Fungal Allergy: Clinical Practice and Unmet Needs
Fungal allergy is an increasingly recognized health issue, affecting a notable proportion of the general population and a ...
The Role of Regnase-1 in Autoimmune Diseases – A Future Therapeutic Target for Clinical Use
The Role of Regnase-1 in Autoimmune Diseases – A Future Therapeutic Target for Clinical Use
Regnase-1, encoded by ZC3H12A gene, is a multifunctional immune regulator that maintains immune homeostasis through its RN...
Regulatory B Cells at the Crossroads of Epigenetic Control and Immune Homeostasis
Regulatory B Cells at the Crossroads of Epigenetic Control and Immune Homeostasis
Regulatory B cells (Bregs) cooperate with FOXP3⁺ regulatory T cells (Tregs) to maintain immune tolerance. Among dive...
Sexual Dimorphism in Allergic and Mast Cell-Associated Diseases
Sexual Dimorphism in Allergic and Mast Cell-Associated Diseases
Allergic diseases are common, affecting more than one-third of the global population and varying widely in severity. A con...
Enzyme−Crosslinked House Dust Mite Exhibits Reduced Allergenic Activity by Reprogramming the AMPKα−RALDH2 Axis in Type 1 Dendritic Cells
Enzyme−Crosslinked House Dust Mite Exhibits Reduced Allergenic Activity by Reprogramming the AMPKα−RALDH2 Axis in Type 1 Dendritic Cells
Enzymatic crosslinking has emerged as an effective strategy to reduce allergenicity, but the underlying immunological mech...
Ferroptosis as a Pathogenic Mechanism and Therapeutic Target in Autoimmune and Inflammatory Skin Diseases
Ferroptosis as a Pathogenic Mechanism and Therapeutic Target in Autoimmune and Inflammatory Skin Diseases
Ferroptosis represents an iron-dependent cell death pathway driven by lipid peroxide accumulation. Recent research has est...
The Evolving Landscape of CAR T-Cell Therapy in Autoimmune Diseases: A State-of-the-Art Review (2025)
The Evolving Landscape of CAR T-Cell Therapy in Autoimmune Diseases: A State-of-the-Art Review (2025)
Autoimmune diseases, characterized by a breakdown in immune tolerance and persistent autoantibody production, have traditi...
Clinical Features, Diagnosis, and Treatment of Eosinophilic Sialodochitis: A Systematic Review of the Literature
Clinical Features, Diagnosis, and Treatment of Eosinophilic Sialodochitis: A Systematic Review of the Literature
Eosinophilic sialodochitis is an under-recognized obstructive inflammatory disorder of the major salivary ducts that has b...
An Update Comprehensive Review on Epigenetic Modifications and Therapies in Autoimmune Diseases
An Update Comprehensive Review on Epigenetic Modifications and Therapies in Autoimmune Diseases
Autoimmune diseases are chronic disorders characterized by dysregulated immune responses directed against self-tissues. Ho...
Extracellular Vesicles in Allergy: From Cellular Communication to Clinical Implications
Extracellular Vesicles in Allergy: From Cellular Communication to Clinical Implications
Extracellular vesicles (EVs) are lipid bilayer-enclosed particles released by both eukaryotic and prokaryotic cells and re...
Multi-Dimensional Perspective of the Gene and Environmental Interaction in Asthma
Multi-Dimensional Perspective of the Gene and Environmental Interaction in Asthma
Asthma is a debilitating disease, and its diagnosis and disease management remain imprecise. It continues to impose a majo...
Clinical Management of Antirheumatic Drug Exposure During Therapeutic Plasma Exchange
Clinical Management of Antirheumatic Drug Exposure During Therapeutic Plasma Exchange
Therapeutic plasma exchange (TPE) is being increasingly utilized in the clinical management of severe rheumatic immune dis...
γδ T Cell-Mediated Neuroimmune Interactions in Skin Inflammation and Allergy
γδ T Cell-Mediated Neuroimmune Interactions in Skin Inflammation and Allergy
γδ T cells represent a distinct subset of immune cells that play pivotal roles in maintaining cutaneous immune h...
Vitiligo as a Failure of Immune Resolution and Tissue Regeneration: From Stress Signals to Targeted Immune Modulation
Vitiligo as a Failure of Immune Resolution and Tissue Regeneration: From Stress Signals to Targeted Immune Modulation
Traditionally, vitiligo is known as a cutaneous autoimmune disease characterized by progressive melanocyte loss. However, ...
T-Cell Immunosenescence in Systemic Lupus Erythematosus: Molecular Mechanisms and Therapeutic Perspectives
T-Cell Immunosenescence in Systemic Lupus Erythematosus: Molecular Mechanisms and Therapeutic Perspectives
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by chronic immune activation, relap...
Pragmatic Strategies for Reducing Variability and Risk in Food Oral Immunotherapy
Pragmatic Strategies for Reducing Variability and Risk in Food Oral Immunotherapy
Oral immunotherapy (OIT) can be effective and relatively safe for the treatment of food allergies, especially when started...
Advancing Treatment in Bullous Pemphigoid: A Comprehensive Review of Novel Therapeutic Targets and Approaches
Advancing Treatment in Bullous Pemphigoid: A Comprehensive Review of Novel Therapeutic Targets and Approaches
Bullous pemphigoid is one of the most common autoimmune bullous diseases occurring primarily in the elderly. Pathogenic au...
A Retrospective Analysis of Long-Term Prophylaxis with Berotralstat in Patients with Hereditary Angioedema and Acquired C1-Inhibitor Deficiency—Real-World Data
A Retrospective Analysis of Long-Term Prophylaxis with Berotralstat in Patients with Hereditary Angioedema and Acquired C1-Inhibitor Deficiency—Real-World Data
Hereditary angioedema (HAE) and acquired C1-inhibitor deficiency (AAE-C1-INH) are orphan diseases. Berotralstat is a recen...
Eosinophil-Associated Gastrointestinal Manifestations During OIT
Eosinophil-Associated Gastrointestinal Manifestations During OIT
Gastrointestinal adverse events are common during oral immunotherapy (OIT) for food allergy and range from immediate IgE-m...
Vernal Keratoconjunctivitis: A Systematic Review
Vernal Keratoconjunctivitis: A Systematic Review
Vernal keratoconjunctivitis (VKC) is a chronic, bilateral corneal and conjunctival problem which typically presents in you...
Treatable Traits in Systemic Sclerosis
Treatable Traits in Systemic Sclerosis
Systemic sclerosis (SSc) is a chronic systemic disease within the spectrum of connective tissue diseases, specifically cha...
Hypersensitivity Reactions to Taxanes: A Comprehensive and Systematic Review of the Efficacy and Safety of Desensitization
Hypersensitivity Reactions to Taxanes: A Comprehensive and Systematic Review of the Efficacy and Safety of Desensitization
Taxanes in the treatment of cancer are associated with a significant incidence of hypersensitivity reactions, which may pr...
Shared Pathogenicity Features and Sequences between EBV, SARS-CoV-2, and HLA Class I Molecule-binding Motifs with a Potential Role in Autoimmunity
Shared Pathogenicity Features and Sequences between EBV, SARS-CoV-2, and HLA Class I Molecule-binding Motifs with a Potential Role in Autoimmunity
Epstein-Barr virus (EBV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are extraordinary in their abili...
Environmental Risk Factors, Protective Factors, and Biomarkers for Allergic Rhinitis: A Systematic Umbrella Review of the Evidence
Environmental Risk Factors, Protective Factors, and Biomarkers for Allergic Rhinitis: A Systematic Umbrella Review of the Evidence
Many potential environmental risk factors, protective factors, and biomarkers of AR have been published, but so far, the s...
During Sepsis and COVID-19, the Pro-Inflammatory and Anti-Inflammatory Responses Are Concomitant
During Sepsis and COVID-19, the Pro-Inflammatory and Anti-Inflammatory Responses Are Concomitant
The most severe forms of COVID-19 share many features with bacterial sepsis and have thus been considered to be a viral se...
γδ T Cells and Allergic Diseases
γδ T Cells and Allergic Diseases
Gamma–delta (γδ) T cells play an essential role in allergic diseases and have emerged as a potential treat...
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