Biswas, R. & Hall, D. A. Prevalence, incidence, and risk factors for tinnitus. Curr. Top. Behav. Neurosci. 51, 3–28 (2021).

Article  CAS  PubMed  Google Scholar 

Biswas, R. et al. Tinnitus prevalence in Europe: a multi-country cross-sectional population study. Lancet Reg. Health Eur. 12, 100250 (2022).

Article  CAS  PubMed  Google Scholar 

Jarach, C. M. et al. Global prevalence and incidence of tinnitus: a systematic review and meta-analysis. JAMA Neurol. 79, 888–900 (2022). This paper provides the most rigorous, large-scale synthesis of worldwide tinnitus prevalence and incidence, giving clinicians, researchers and policy-makers a reliable baseline for how common tinnitus is and how often new cases arise.

Article  PubMed  PubMed Central  Google Scholar 

De Ridder, D. et al. Tinnitus and tinnitus disorder: theoretical and operational definitions (an international multidisciplinary proposal). Prog. Brain Res. 260, 1–25 (2021). This paper establishes internationally agreed theoretical and operational definitions that clearly distinguish ‘tinnitus’ from ‘tinnitus disorder’, enabling more consistent diagnosis, research design and comparison of results across studies.

PubMed  Google Scholar 

Elgoyhen, A. B., Langguth, B., De Ridder, D. & Vanneste, S. Tinnitus: perspectives from human neuroimaging. Nat. Rev. Neurosci. 16, 632–642 (2015).

Article  CAS  PubMed  Google Scholar 

Sedley, W., Friston, K. J., Gander, P. E., Kumar, S. & Griffiths, T. D. An integrative tinnitus model based on sensory precision. Trends Neurosci. 39, 799–812 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Maihoub, S., Mavrogeni, P., Molnar, V. & Molnar, A. Tinnitus and its comorbidities: a comprehensive analysis of their relationships. J. Clin. Med. 14, 1285 (2025).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Langguth, B., Kreuzer, P. M., Kleinjung, T. & De Ridder, D. Tinnitus: causes and clinical management. Lancet Neurol. 12, 920–930 (2013). A landmark clinical review that synthesizes tinnitus causes, mechanisms and evidence-based management into a practical framework that has guided modern diagnosis and treatment.

Article  PubMed  Google Scholar 

McCormack, A., Edmondson-Jones, M., Somerset, S. & Hall, D. A systematic review of the reporting of tinnitus prevalence and severity. Hear. Res. 337, 70–79 (2016).

Article  PubMed  Google Scholar 

Baguley, D., McFerran, D. & Hall, D. Tinnitus. Lancet 382, 1600–1607 (2013).

Article  PubMed  Google Scholar 

Gallus, S. et al. Prevalence and determinants of tinnitus in the Italian adult population. Neuroepidemiology 45, 12–19 (2015).

Article  PubMed  Google Scholar 

Batts, S. & Stankovic, K. M. Tinnitus prevalence, associated characteristics, and related healthcare use in the United States: a population-level analysis. Lancet Reg. Health Am. 29, 100659 (2024).

PubMed  PubMed Central  Google Scholar 

Shargorodsky, J., Curhan, G. C. & Farwell, W. R. Prevalence and characteristics of tinnitus among US adults. Am. J. Med. 123, 711–718 (2010).

Article  PubMed  Google Scholar 

GBD 2021 Forecasting Collaborators. Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the global burden of disease study 2021. Lancet 403, 2204–2256 (2024).

Article  Google Scholar 

GBD 2019 Ageing Collaborators. Global, regional, and national burden of diseases and injuries for adults 70 years and older: systematic analysis for the Global Burden of Disease 2019 Study. BMJ 376, e068208 (2022).

Google Scholar 

Jarach, C. M., Simoes, J. P., Schlee, W., Langguth, B. & Gallus, S. Urgent support is needed for more tinnitus research. J. Epidemiol. 35, 382–383 (2025).

Article  PubMed  PubMed Central  Google Scholar 

Biswas, R. et al. Low evidence for tinnitus risk factors: a systematic review and meta-analysis. J. Assoc. Res. Otolaryngol. 24, 81–94 (2023).

Article  PubMed  Google Scholar 

Tan, C. M., Lecluyse, W., McFerran, D. & Meddis, R. Tinnitus and patterns of hearing loss. J. Assoc. Res. Otolaryngol. 14, 275–282 (2013).

Article  PubMed  PubMed Central  Google Scholar 

Cederroth, C. R., Trpchevska, N. & Langguth, B. A new buzz for tinnitus-it’s in the genes! JAMA Otolaryngol. Head Neck Surg. 146, 1025–1026 (2020).

Article  PubMed  Google Scholar 

Cederroth, C. R. et al. Association between hyperacusis and tinnitus. J. Clin. Med. 9, 2412 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Aazh, H., Moore, B. C., Lammaing, K. & Cropley, M. Tinnitus and hyperacusis therapy in a UK National Health Service audiology department: patients’ evaluations of the effectiveness of treatments. Int. J. Audiol. 55, 514–522 (2016).

Article  PubMed  PubMed Central  Google Scholar 

Kujawa, S. G. & Liberman, M. C. Adding insult to injury: cochlear nerve degeneration after “temporary” noise-induced hearing loss. J. Neurosci. 29, 14077–14085 (2009).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen, F., Zhao, F., Mahafza, N. & Lu, W. Detecting noise-induced cochlear synaptopathy by auditory brainstem response in tinnitus patients with normal hearing thresholds: a meta-analysis. Front. Neurosci. 15, 778197 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Gopinath, B., McMahon, C. M., Rochtchina, E., Karpa, M. J. & Mitchell, P. Risk factors and impacts of incident tinnitus in older adults. Ann. Epidemiol. 20, 129–135 (2010).

Article  PubMed  Google Scholar 

Kacprzyk, A. et al. The impact of mobile phone use on tinnitus: a systematic review and meta-analysis. Bioelectromagnetics 42, 105–114 (2021).

Article  PubMed  Google Scholar 

Vasilkov, V. et al. Evidence of cochlear neural degeneration in normal-hearing subjects with tinnitus. Sci. Rep. 13, 19870 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sismanis, A. Pulsatile tinnitus. Otolaryngol. Clin. North Am. 36, 389–402 (2003).

Article  PubMed  Google Scholar 

Edvall, N. K. et al. Impact of temporomandibular joint complaints on tinnitus-related distress. Front. Neurosci. 13, 879 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Lee, C. F. et al. Increased risk of tinnitus in patients with temporomandibular disorder: a retrospective population-based cohort study. Eur. Arch. Otorhinolaryngol. 273, 203–208 (2016).

Article  PubMed  Google Scholar 

Stohler, N. A., Reinau, D., Jick, S. S., Bodmer, D. & Meier, C. R. A study on the epidemiology of tinnitus in the United Kingdom. Clin. Epidemiol. 11, 855–871 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Deklerck, A. N., Debacker, J. M., Keppler, H. & Dhooge, I. J. M. Identifying non-otologic risk factors for tinnitus: a systematic review. Clin. Otolaryngol. 45, 775–787 (2020).

Article  PubMed  Google Scholar 

Levine, R. A., Nam, E. C., Oron, Y. & Melcher, J. R. Evidence for a tinnitus subgroup responsive to somatosensory based treatment modalities. Prog. Brain Res. 166, 195–207 (2007).

Article  CAS  PubMed  Google Scholar 

Michiels, S. Somatosensory tinnitus: recent developments in diagnosis and treatment. J. Assoc. Res. Otolaryngol. 24, 465–472 (2023). This is an important paper synthesizing the latest evidence on somatosensory tinnitus, highlighting how to identify it clinically and which targets are most promising for treatment.

Article  PubMed  PubMed Central  Google Scholar 

Lugo, A. et al. Relationship between headaches and tinnitus in a Swedish study. Sci. Rep. 10, 8494 (2020).

Article  CAS  PubMed